Category: 530-40-5

Skorupska, Ewa A. published the artcileDynamic ¹H NMR spectroscopic study of hindered internal rotation in selected N,N-dialkyl isonicotinamides: an experimental and DFT analysis, Formula: C10H14N2O, the publication is Tetrahedron (2013), 69(38), 8147-8154, database is CAplus.

Dynamic ¹H NMR measurements were performed for N,N-dialkyl isonicotinamides (alkyl = Me, Et, and Me₂CH). Two complementary methods of the anal. of these spectra were used, targeting the estimation of rates of alkyl group exchange and thereby parameters for rotation around the C-N bond. The Gibbs free activation energy in DMSO, ΔG_exp^≠, is 67.6, 65.3, and 61.4 kJ mol^-1, resp. This finding was compared with related DFT and MP2 results on simulated solutions, ΔG_calcd^≠s, in search of the best theor. tool reflecting the observed trend that ΔG_exp^≠ reduces with an increasing bulkiness of the N-alkyl group. Especially, the DFT methods recommended for TS geometry and barrier height calculations were used. The barriers to C_ar-C(O) bond rotation were also computed, although not measured exptl. An IRC anal. was also carried out. As a result, the above trend was rationalized by steric hindrance in the ground-state forms under study. The changes in their geometric parameters, including pyramidicity descriptors, are fully consistent with such explanation. Among all DFT methods tested, only the use of the BB1K/6-31+G(d,p)/IEF-PCM(DMSO) protocol afforded ΔG_calcd^≠s fully comparable to the present DNMR determinations

Tetrahedron published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C12H14BNO2, Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Koyama, Junko published the artcileStructure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds, HPLC of Formula: 530-40-5, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(4), 1079-1082, database is CAplus and MEDLINE.

Antimicrobial activities of two azafluorenones, four 1-azaanthraquinones, five 2-azaanthraquinones, and one 2-azaquinone were tested. Several azaanthraquinones possessed broad, potent activity, while the azafluorenones demonstrated weak activity. The following structure-activity relationship was postulated: (1) activity decreased in the order 2-azaanthraquinones > 1-azaanthraquinones > azafluorenones; and (2) a hydroxyl group at the peri-carbonyl group enhanced activity. In addition, correlations among reduction potential, hydrophobic parameter, and antimicrobial activity were discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, HPLC of Formula: 530-40-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Titskii, G. D. published the artcileIsoparametric correlations in reactions of 4-R-N-arylpyridinium salts with arylamines, Recommanded Product: N,N-Diethylisonicotinamide, the publication is Theoretical and Experimental Chemistry (Translation of Teoreticheskaya i Eksperimental’naya Khimiya) (2000), 35(4), 215-220, database is CAplus.

Isoparametric dependencies of the structure of the reagents (including noncatalytic rate constants, substitution constants (σ⁰), basicity constants, and charges at the reaction centers) were obtained for the reactions between 4-R-N-(2,4-dinitrophenyl)pyridinium salts with arylamines. The electron-acceptor 4-R-substituents studied reduced the pos. charge on the reaction center (the α-atom) and the N atom of the N-arylpyridinium cation.

Theoretical and Experimental Chemistry (Translation of Teoreticheskaya i Eksperimental’naya Khimiya) published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C9H9F5Si, Recommanded Product: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Cohen, Irit published the artcileSunlight assisted direct amide formation via a charge-transfer complex, Name: N,N-Diethylisonicotinamide, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(73), 10128-10131, database is CAplus and MEDLINE.

We report on the use of charge-transfer complexes between amines and carbon tetrachloride, as a novel way to activate the amine for photochem. reactions. This principle is demonstrated in a mild, transition metal free, visible light assisted, dealkylative amide formation from feedstock carboxylic acids and amines. The low absorption coefficient of the complex allows deep light penetration and thus scale(coating process) up to a gram scale.

Chemical Communications (Cambridge, United Kingdom) published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Name: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sam, Joseph published the artcileHypotensive agents. Pyridinecarboxamides and piperidinecarboxamides, Related Products of amides-buliding-blocks, the publication is Journal of the American Chemical Society (1959), 710-13, database is CAplus.

Nicotinic acid (100 g.) in 2 l. CH₂Cl₂ treated gradually with 81 g. Et₃N, the mixture treated at 0-5° with 95 g. ClCO₂Et during 15-20 min., kept 0.5 hr. at 0°, treated with 57 g. pyrrolidine at 0-5°, warmed to room temperature, after 2 hrs. washed twice with 150 cc. H₂O, and distilled gave 90 g. 1-nicotinoylpyrrclidine, b_0.3 131-3°; methiodide m. 213.5-14.5° (MeCN), 87% yield. Similarly were prepared the following compounds (b.p./mm. and % yield given): N,N-diethylamide of isonicotinic acid (I), 109°/0.5 62; morpholide (II) of I, 142-5°/0.4, 55 [II.PhCH₂CH₂Br m. 214-15° (MeOH-Me₂CO), 97%]; morpholide (III) of nicotinic acid (IV), 190-5°/0.4, 48 [III.PhCH₂CH₂Br m. 212-13° (MeOH-Et₂O), 95%]; morpholide (V) of pyridine-2-carboxylic acid (VI), 142-3°/1, 59 [VI.MeI m. 175-6° (MeOH), 81%]; 2,6-dimethylmorpholide of IV, 138-40°/0.5, 57; 2,6-dimethylmorpholide (VII) of I, 135-7°/0.3, 50 [VII.PhCH₂CH₂Br m. 227-8° (MeOH-Et₂O), 94%]; 2,6-dimethylpiperidide of I, – (m. 73-4°), 20; 4-methylpiperazide of I, 133-5°/0.4, 39; p-ethoxyanilide (VIII) of IV, – (m. 170-5°), 50 [VIII.MeI m. 194-6°, 92%; VIII.PhCH₂CH₂Br m. 243-4° (MeOH), 88%]; p-dimethylaminoanilide (IX) of VI, -, 60 [IX.2HCl m. 227-30° (decomposition); IX.MeI m. 229-30° (decomposition)(MeOH), 98%]; p-dimethylaminoanilide (X) of IV, – (m. 185-7°), 25 [X.MeI m. 230-5° (decomposition)(MeOH), 95%]; p-dimethylaminoanilide (XI) of I, -, 38 [X.2HCl m. 175° (decomposition); X.MeI m. above 200° (decomposition)(MeOH), 90%]. The appropriate pyridinecarboxamide in MeOH or MeCN refluxed 24 hrs. with 10-20% suitable halide, the resulting quaternary salts in H₂O or EtOH hydrogenated over PtO₂ (0.3 g./0.1 mole) at 50-60 lb. during 15-30 hrs., filtered, basified strongly with 50% aqueous NaOH, extracted with Et₂O, and the extract worked up yielded the corresponding piperidinecarboxamide. N,N-Diethylnipecotamide (XII) (19 g.), 20 g. PhCH:CHCH₂Br, and 20 g. K₂CO₃ in 200 cc. PhMe refluxed 3 hrs. with stirring, cooled, washed with H₂O, dried, and distilled yielded 27 g. 1-cinnamyl derivative of XII, b_0.4 184-7°. Similarly were prepared the following 1-substituted piperidinecarboxamides (b.p./mm. and % yield given): 1-Ph(CH₂)₂ deriv, of XII, 173°/0.3, 86 (n²⁷_D 1.5221); 1-Ph₂CH derivative of XII.HBr, -, 20 [m. 234.5-35° (MeOH)]; 1-PhCH₂ derivative of the 4-isomer of XII, 173-5°/0.7, 87; 1-Me derivative of the pyrrolidide (XIII) of nipecotic acid (XIV), 111-14°/0.3, 89; 1-PhCH₂CH₂ derivative of XIII, 181-3°/0.1, 62 (n²⁵_D 1.5431); morpholide (XIV) of piperidine-2-carboxylic acid (XV), 143-5°/1.5, 65; 1-Me derivative of XIV, 121-3°/0.8, 87 (n³²_D 1.5013); 1-PhCH₂CH₂ derivative of XIV, 192-5°/0.4, 16 (n²⁴_D 1.5426); 1-Me derivative of the morpholide (XVI) of XIV, 118°/0.2, 72 (n^25.5_D 1.5065); 1-PhCH₂ derivative of XVI, 183-6°/0.3, 80; 1-PhCH₂CH₂ derivative of XVI, 188-92°/0.2, 85 (n³⁴_D 1.5406); 1-Ph(CH₂)₃ derivative of XVI, 203-6°/0.3, 71; 1-PhCH₂CH₂ derivative (XVII) of the morpholide of isonipecctic acid (XVIII), -, 85 [XVIII.HBr m. 279-80° (MeOH)]; 1-PhCH₂CH₂ derivative of the 2,6-dimethylmorpholide of XIV, 188-90°/0.2, 50 (n^24.5_D 1.5327); 1-PhCH₂CH₂ derivative (XIX) of the 2,6-dimethylmorpholide of XVIII, -, 78 [XIX.HBr m. 252-4° (H₂O)]; 1-Me derivative of the p-ethoxyanilide (XX) of XIV, -, 77 [m. 122-3° (aqueous MeOH)]: 1-PhCH₂CH₂ derivative (XXI) of XX, -, 82 [XXI.HBr m. 108-10° (decomposition) (Me₂CO)]; p-dimethylaminoanilide (XXII) of XV, -, 93 [m. 127-30° (aqueous MeOH)] [XXII.2HCl m. 248-50° (decomposition)(MeOH)]; p-dimethylaminoanilide (XXIII) of XVIII, [m. 197-8° (MeOH)], 90 [XXIII.2HCl m. 252-4° (decomposition) (MeOH)]. The appropriate 1-methylpiperidinecarboxamide reduced with LiAlH₄ yielded the corresponding alkylaminomethyl derivatives of 1-methylpiperidine (alkylamino group, b.p./mm., % yield, m.p., and % yield of dimethiodide given): 3-pyrrolidino, 59°/0.3, 93, 264-6° (decomposition), 94(at 25° in MeCN); 2-morpholino, 79-82°/0.4, 63, 255-6° (decomposition), 55 (refluxed 6 hrs. in MeCN); 3-morpholino, 87-8°/0.8 (n^25.5_D 1.5202), -, 281-2° (decomposition), – (refluxed 6 hrs. in MeOH). 1-Nicotinoylpyrrolidine in Et₂O reduced with LiAlH₄ yielded 44% 3-pyrrolidinomethylpyridine, b_0.2 75-7°, n^25.5_D 1.5202. XII (27.6 g.) and 18.2 g. styrene oxide heated 18 hrs. on the steam bath, the mixture dissolved in Et₂O and extracted with 6N HCl, the extract neutralized with NaOH and extracted with Et₂O, and the extract worked up gave 32.2 g. N,N-diethyl-1-(2-hydroxy-2-phenylethyl)nipecotamide, b_3.5 228-30°. XII (27.6 g.), 23.6 g. p-O₂NC₆H₄Cl, and 20.2 g. Et₃N heated 20 hrs. on the steam bath, cooled, triturated with H₂O, and filtered gave 45.1 g. N,N-diethyl-1-(p-nitrophenyl)nipecotamide (XXIV), m. 99.5-101.5° (EtOH). XXIV (15.3 g.) in 200 cc. EtOH hydrogenated at room temperature and 50 lb. over Raney Ni during 15 min., filtered, evaporated, the residue dissolved in Et₂O, and the solution saturated with dry Et₂O yielded 50% p-NH₂ analog di-HCl salt of XXIV, m. 227.5-8.5° (MeOH-EtOAc). 3-(3-Pyridyl)-acrylic acid (prepared in 79% yield from 3-pyridinecarboxaldehyde and malonic acid) treated in the usual manner with ClCO₂Et and morpholine in CH₂Cl₂ yielded 79% 4-[3-(3-pyridyl)acrylyl]morpholine (XXVI), m. 141-3° (MeCN). XXVI in MeOH hydrogenated at 60 lb. over 5% Pd-C yielded 87% 4-[3-(3-pyridyl)propionyl]morpholine (XXVII), b₁ 188-90°, n^24.5_D 1.5457. XXVII and excess PhCH₂CH₂Br in MeCN refluxed 18 hrs., the MeCN removed in vacuo, the residual oil dissolved in H₂O, the solution hydrogenated over PtO₂ at 60 lb. and 50°, and the mixture worked up in the usual manner yielded 84% 4-[3-(1-phenethyl-3-piperidyl)propionyl]morpholine, b_0.3 217-19°.

Journal of the American Chemical Society published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gabryelski, Wlad. published the artcileAbsorption of ultra-violet light by some organic substances. XXVIII, Recommanded Product: N,N-Diethylisonicotinamide, the publication is Bulletin International de l’Academie Polonaise des Sciences et des Lettres, Classe des Sciences Mathematiques et Naturelles, Serie A: Sciences Mathematiques (1933), 87-94, database is CAplus.

cf. C. A. 24, 21. The following substances do not cause selective absorption of ultra-violet light between 4900 and 2100 A. U.: cellobiose (in H₂O), raffinose, acetylcellobiose, β-acetyllactobiose (in CHCl₃), acetylsucrose (in CHCl₃), acetylmaltose (in CHCl₃). The 2 absorption bands with maximum at 2680 and 3200 A. U., which appear when glucose is treated with NaOH in weak concentrations (C. A. 26, 5078) are probably due to the aldehyde form, for if the NaOH is neutralized with HCl after a short time, the original spectrum showing practically no selective absorption is obtained. Prolonged action of OH^– on glucose gives a product showing selective absorption which does not disappear on addition of acid.

Bulletin International de l’Academie Polonaise des Sciences et des Lettres, Classe des Sciences Mathematiques et Naturelles, Serie A: Sciences Mathematiques published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Recommanded Product: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ciusa, Walter published the artcile1-Alkyl derivatives of isonicotinic acid diethylamide, Product Details of C10H14N2O, the publication is Gazzetta Chimica Italiana (1960), 147-154, database is CAplus.

cf. CA 52, 2850c. A series of quaternary ammonium salts, 4-Et₂NCOC₅H₄N.RX (R = C_nH_2n+1 (n = 1-18), X = I, Br, Cl) (I), was prepared and the chem. and pharmacol. properties were investigated and compared with those of the analogous derivatives of 3-Et₂NCOC₅H₄N (II). I were prepared by refluxing 0.2 mole 3-Et₂NCOC₅2 hrs. in 100-200 ml. xylene with 0.4 mole RX. I (X = Cl) were prepared from 0.1 mole I (X = Br, I) in 100-300 ml. H₂O by stirring 1 hr. with 0.2 mole freshly prepared AgCl. The following I were prepared [RX, % yield, and m.p. (alc.Et₂O) given]: MeI, 78, 137°; EtI, 84, 104°; Me₂CHI, 60, 78°; BuI, 75, 160°; C₅H₁₁I, 95, 140°; C₁₂H₂₅I, 52, 60°; C₆H₁₃Br, 70, -; C₈H₁₇Br, 70, -; C₁₀H₂₁Br, 70, 43°; C₁₄H₂₉Br, 90, 55°; C₁₆H₃₃Br, 75, 53°; C₁₈H₃₇Br, 86, 101°. Yields indicated that ease of alkylation was practically the same in both series of amides. The following I (X = Cl) were prepared (R and m.p. given): Me, 188°; Et, 145°; Me₂CH, 175°; Bu, 132°; C₅H₁₁, 67°; C₆H₁₃, -(yellow wax); C₈H₁₇, -(yellow wax); C₁₀H₂₁, 51°; C₁₂H₂₅, 59°; C₁₄H₂₉, 74°; C₁₆H₃₃, 66°; C₁₈H₃₇, 83°. The stability of the pyridine ring in I was shown by lack of coloration on boiling with increasing concentrations of aqueous NaOH for prolonged periods. The values of surface tension of members of the series (I) coincided practically with those of corresponding members of the normal series. The antibacterial activity as tested on Staphylococcus aureus showed maximum activity with n = 16 and 18, and was parallel to that noted in the normal series. In tests on the isolated frog heart, arrested beat occurred in 1 min. with 10^-8 mole I (n < 6) and II, and with 10^-6 mole I (n > 8) and tetradecylbenzyldimethylammonium chloride. Compounds in the normal series acted similarly.

Gazzetta Chimica Italiana published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Product Details of C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhou, Jun published the artcileRhodium(III)-catalyzed oxidative olefination of picolinamides: Convenient synthesis of 3-alkenylpicolinamides, Category: amides-buliding-blocks, the publication is Advanced Synthesis & Catalysis (2014), 356(5), 1038-1046, database is CAplus.

A rhodium(III)-catalyzed selective olefination of picolinamide derivatives has been developed. The reaction shows high regioselectivity, low catalyst loading (0.5 mol%), high yield, and good functional group tolerance, providing a convenient strategy for the synthesis of 3-alkenylpicolinamides.

Advanced Synthesis & Catalysis published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C28H41N7O4, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Klosa, Josef published the artcileSynthesis of carboxylic acid amides from carboxylic acids and amines by means of polyphosphoric acid, Application In Synthesis of 530-40-5, the publication is Journal fuer Praktische Chemie (Leipzig) (1966), 31(1-2), 41-8, database is CAplus.

4-Amino-1-phenyl-2,3-dimethyl-5-pyrazolone (I) (100 g.) and 62 g. nicotinic acid (II) added with stirring in portions at 100-10° to 300 g. polyphosphoric acid (III) and heated 1.5-2 hrs. at 160-80° gave 135-40 g. 4-(pyridine-3-carboxamido)-2,3-dimethyl-1-phenyl-5-pyrazolone (IV), m. 256-8°. I (100 g.) and 62 g. II treated with 300-400 g. III, heated with occasional stirring to 100-20° and then during 1-2 hrs. to 160-80°, poured into 1-2 l. H₂O, and stirred 1-2 hrs. gave 145 g. IV. Similarly were prepared the following analogs of IV (4-substituent, m.p., and % yield given): pyridine-4-carboxamido, 273-5°, 90; 6-methylpyridine-2-carboxamido, 206-8°, 80; 4-methylpyridine-3-carboxamido, 248-60°, 65; 4-ethylpyridine-3-carboxamido, 240-2°, 70; 2,4-dimethylpyridine-3-carboxamido, 267-9° (MeOH), 75; 2,6-dimethyl-3-pyridinecarboxamido, 264-6° (MeOH), 85; 2-methylpyridine-5-carboxamido, >280° (decomposition), 78; 2-methylpyridine-4-carboxamido, >300° (decomposition), 70; 2,4,6-trimethylpyridine-3-carboxamido, >300° (decomposition with charring), 82; 2,3,4-trimethylpyridine-5-carboxamido, >300° (decomposition with charring), 80; 6-phenylpyridine-5-carboxamido, 270-2° (decomposition), 65; 2-methyl-6-phenylpyridine-3-carboxamido, >290° (decomposition), 65; 4-chloropyridine-2-carboxamido, >265-7° (decomposition), 65; 5-chloropyridine-2-carboxamido, >280° (decomposition), 75; 2-chloropyridine-3-carboxamido, from 260° (decomposition), 70; 3-chloropyridine-4-carboxamido, >300° (decomposition), 85; 4,6-dichloropyridine-2-carboxamido, from 250° (decomposition with browning), 68; 2,3-dichloropyridine-5-carboxamido, from 260° (decomposition and browning), 88; 2,6-dichloropyridine-4-carboxamido, >280°, 85; 2-hydroxypyridine-5-carboxamido, >300°, 65; 2-hydroxy-3-chloropyridine-5-carboxamido, >300° (decomposition), 60; 2-hydroxy-6-chloropyridine-4-carboxamido, from 270° (decomposition), 65; 2-phenylquinoline-4-carboxamido, 245-7°, 90; 2-phenyl-6-methoxyquinoline-4-carboxamido, 282-4°, 75. Similarly were prepared the following compounds (m.p. or b.p. and % yield given): p-ethoxyanilide of II, 170-2°, 60; diethylamide of II, 276-8°/760 mm., 65; piperidide of II, 314-16°/760, 60; diethylamide of isonicotinic acid (V), 26-8°, 68; p-ethoxyanilide of V, 198-290°, 75; 2-methylpyridine-5-carboxanilide (VI), 138-40°, 68; 2-Ph analog of VI, 200-2°, 70.

Journal fuer Praktische Chemie (Leipzig) published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Application In Synthesis of 530-40-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gryszkiewicz-Trochimowski, E. published the artcileAmides of carboxylic acids of the heterocyclic series, Application of N,N-Diethylisonicotinamide, the publication is Roczniki Chemii (1931), 193-202;201-2 in French, database is CAplus.

In analogy with the N-diethylamide of 3-pyridinecarboxylic acid coramine, 3 new diethylamides were prepared, viz., of 2-pyridinecarboxylic, of 4-pyridinecarboxylic and of tetramethylpyrrolinecarboxylic acid, resp., and their chem. and physiol. properties were investigated. Picolinyl chloride (I) is prepared according to Meyer, Monatsh. 22, 112(1901), from the acid (II) and SOCl₂. N-Diethylamide of II, prepared from pulverized (I) and dry Et₂NH, almost odorless oil of bitter taste, neutral, m. 26-8°, b₃ 122.5-3°, corrected, d₄^16.2 1.0603, n_α^16.2 1.5209, n_D^16.2 1.5254, n_β^16.2 1.5348. Coramine, m. 21-3°, b₃ 128.5-9°, corrected, n_α16.2 1.5235, n_D^16.2 1.5279, n_β^16.2 1.5391. N-Diethylamide of 4-pyridinecarboxylic acid (isonicotinic acid), prepared similarly to II, is a neutral, viscous oil, m. 22-4°, b₃ 123-3.5°, corrected, d₄^16.2 1.0630, n_α^16.2 1.5225, n_D^16.2 1.5269, n_β^16.2 1.5380. N-Diethylamide of 2,2′,5,5′-tetramethylpyrrolinecarboxylic acid (III), prepared by interaction of dibromotriacetoneamine-HBr (prepared according to Pauly, Ber. 31, 672), and 33% aqueous Et₂NH, m. 33-4°, b₉ 129.5-30°. It tastes bitter and reacts strongly alk. The 3 diethylamides differ in their physiol. action. The 2-isomer has an action on the heart similar to that of coramine, but does not affect the nervous system. The physiol. action of III is entirely different from that of coramine.

Roczniki Chemii published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Application of N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics