Category: 52898-49-4

Adding a certain compound to certain chemical reactions, such as: 52898-49-4, name is N,4-Dimethoxy-N-methylbenzamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52898-49-4, name: N,4-Dimethoxy-N-methylbenzamide

General procedure: In a helium-filled glove box, the desired number ofequivalents of Na-AG or Na-SG were added to a round bottom flask, along with aglass-coated stir bar, and the flask sealed with a septum. This closed systemwas then taken out of the glove box, continuously purged with nitrogen, followedby injection of the pure synthesized Weinreb amide dissolved in THF. The resulting mixture was stirred for thetime specified. After completion of the reaction, the mixture was then partitioned using ethyl acetate and brine. The organic layer was concentrated under reducedpressure using a rotary evaporator. 1H NMR of the crude product wastaken to check for reaction extent/completion and to identify the productsobtained. Crude product was fractionated and purified by columnchromatography on silica gel to afford the desired product and byproducts.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,4-Dimethoxy-N-methylbenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jackson, James E.; O’Brien, Brittany N.; Kedzior, Sonya K.; Fryz, Gage R.; Jalloh, Fatmata S.; Banisafar, Arash; Caldwell, Michael A.; Braun, Max B.; Dunyak, Bryan M.; Dye, James L.; Tetrahedron Letters; vol. 56; 45; (2015); p. 6227 – 6230;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 52898-49-4, A common heterocyclic compound, 52898-49-4, name is N,4-Dimethoxy-N-methylbenzamide, molecular formula is C10H13NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The preparation method is as follows:Ethylene glycol acetal (458 mg, 2 mmol) of 3-bromobenzaldehyde,Dissolved in 5 mL of dry tetrahydrofuran,N-Butyllithium (0.8 mL, 2 mmol) was slowly added dropwise at -70 C,After 1 hour, N-methyl-N-methoxy 4-methoxybenzamide (332 mg, 1.7 mmol) was added slowly at -70 C,The reaction was continued at -70 C for 2 hours,The reaction was quenched by adding 5 mL saturated brine and the organic phase was extracted with ethyl acetate (10 mL * 3)The combined organic phase,Drying over anhydrous sodium sulfate. Spin the solvent,Column chromatography (petroleum ether: ethyl acetate = 20: 1 as eluant),The reaction product 386mg.The reaction product was dissolved in 5 mL of dry methanol,1mL 6N hydrochloric acid was added at room temperature, the reaction for 1 hour,The reaction was quenched by addition of saturated sodium bicarbonate solution,The organic phase was extracted with ethyl acetate (10 mL * 3), the organic phases were combined,Drying over anhydrous sodium sulfate. Spin the solvent,Column chromatography (petroleum ether: ethyl acetate = 20: 1 as eluant),The reaction product of 3- (4-methoxybenzoyl) formylbenzaldehyde 294mg, 72% yield in two steps.

The synthetic route of 52898-49-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tsingtao Ocean Bio-pharmaceutical Institute Co., Ltd.; Li Wenbao; Sun Tianwen; Wang Shixiao; Zhao Jianchun; Hou Yingwei; Guan Huashi; (16 pag.)CN107286137; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics