Category: 5238-56-2

Related Products of 5238-56-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5238-56-2 name is N-(2-Hydroxyethyl)methacrylamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of glycosyl donor10 1 (0.635 gm, 1 mmol), glycosyl acceptor 10b (0.142 g 1.1 mmol) and 4 A molecular sieves powder (100 mg) in anhydrous CH2Cl2 (10 mL) was added AuBr3 (0.031 g, 0.07 mmol) under argon atmosphere at room temperature. The reaction mixture was stirred at room temperature for the specified time and the completion of the reaction is judged by TLC analysis. The reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to obtain a crude residue which was purified by conventional silica gel column chromatography using ethyl acetate-petroleum ether as mobile phase to obtain compound 11b.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-(2-Hydroxyethyl)methacrylamide, and friends who are interested can also refer to it.

Reference:
Article; Thadke, Shivaji A.; Kar, Mritunjoy; Gupta, Sayam Sen; Hotha, Srinivas; Carbohydrate Research; vol. 346; 12; (2011); p. 1511 – 1518;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 5238-56-2,Some common heterocyclic compound, 5238-56-2, name is N-(2-Hydroxyethyl)methacrylamide, molecular formula is C6H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N-(2-hydroxyethyl) methacrylamide (3.30 mL, 25.6 mmol, 1.0 eq), triethylamine (7.15 mL, 51.2 mmol, 2.0 eq) and 50 mL DCM were added into a 250 mL flask. After the reaction system was cooled down by an ice bath, butyric anhydride (5.00 mL, 30.7 mmol, 1.2 eq) was added dropwise under the protection of nitrogen. The system was allowed to react overnight. The reaction mixture was filtered and washed by NH4CI solution, NaHCCb solution, and water. After dried by anhydrous MgSC , the organic layer was concentrated by rotary evaporation and purified on a silica column using DCM/MeOH. The product N- butanoyloxyethyl methacrylamide (3) was obtained as pale yellow oil (4.56 g, 89.6%) and analyzed by 1H-NMR (500 MHz, CDCb) deltaEta ppm 0.95 (t, 3H, CH2CH2-CH3), 1.66 (m, 2H, CH2-CH2), 1.97 (s, 3H, C(CH2)-CH3), 2.32 (t, 2H, CO-CH2), 3.59 (dt, 2H, NH-CH2), 4.23 (t, 2H, O-CH2), 5.35 (s, IH, CCH2), 5.71 (s, IH, CCH2), 6.19 (br s, IH, NH). This example demonstrates the feasibility of attaching pharmaceutically-active small molecules to a monomeric unit of the block copolymer. Additional SCFAs can be attached to the monomeric unit in a similar manner.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-(2-Hydroxyethyl)methacrylamide, its application will become more common.

Reference:
Patent; THE UNIVERSITY OF CHICAGO; HUBBELL, Jeffrey A.; WANG, Ruyi; WILSON, D. Scott; NAGLER, Cathryn R.; PLUNKETT, Catherine; (90 pag.)WO2018/195067; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 5238-56-2,Some common heterocyclic compound, 5238-56-2, name is N-(2-Hydroxyethyl)methacrylamide, molecular formula is C6H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Aminoethanol (Manufactured by Tokyo Chemical Industry; 19.4 g, 0.318 mol), and 400 mL of anhydrous tetrahydrofuran were put into a 1-liter four-necked flask, stirred, and cooled to an internal temperature of -10 C. Seventy milliliters of an anhydrous tetrahydrofuran solution of methacrylic acid chloride (16.6 g, 0.159 mol) was then added dropwise over the course of 30 minutes at 5 C. or lower. After the dropwise addition of the solution, the resulting mixture was stirred for 3 hours under room temperature conditions. After the reaction, insoluble matters were removed by filtration, and the filtrate was concentrated under reduced pressure. This produced hydroxyethyl methacrylamide as a pale yellow liquid. The hydroxyethyl methacrylamide (12.9 g, 0.10 mol) obtained by the procedure described above, 200 mL of anhydrous tetrahydrofuran, and triethylamine (15.2 g, 0.15 mol) were put into a 500-milliliter four-necked flask, stirred, and cooled to an internal temperature of -10 C. Fifty milliliters of an anhydrous tetrahydrofuran solution of methacrylic acid chloride (15.7 g, 0.15 mol) was then added dropwise over the course of 30 minutes at 5 C. or lower. After the dropwise addition of the solution, the resulting mixture was stirred for 3 hours under room temperature conditions. After the reaction, triethylamine hydrochloride was removed by filtration, and the filtrate was concentrated under reduced pressure. The concentrated residue was purified by silica gel column chromatography (developing solvent: ethyl acetate). After the column purification, the solvent was removed under reduced pressure using a rotary evaporator, and a pale yellow liquid was obtained. The liquid was subjected to LC-MS analysis and 1H-NMR measurement. It was determined from the locations and integrals of signals that the pale yellow liquid was a target compound. The weight yield was 10.8 g, and the percentage yield was 54.8%. MS m/z: 198 (M+H)+ 1H-NMR (270 MHz CDCl3): delta 1.92 (m, 3H), 1.94 (m, 3H), 3.65 (m, 2H), 4.27 (m, 2H), 5.34 (m, 1H), 5.58 (m, 1H), 5.68 (m, 1H), 6.11 (m, 1H), 6.29 (s, 1H) (ppm)

The synthetic route of 5238-56-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KURARAY NORITAKE DENTAL INC.; NOJIRI, Yamato; TAKEI, Mitsuru; (33 pag.)US2018/360696; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 5238-56-2, The chemical industry reduces the impact on the environment during synthesis 5238-56-2, name is N-(2-Hydroxyethyl)methacrylamide, I believe this compound will play a more active role in future production and life.

General procedure: To a solution of glycosyl donor10 1 (0.635 gm, 1 mmol), glycosyl acceptor 10b (0.142 g 1.1 mmol) and 4 A molecular sieves powder (100 mg) in anhydrous CH2Cl2 (10 mL) was added AuBr3 (0.031 g, 0.07 mmol) under argon atmosphere at room temperature. The reaction mixture was stirred at room temperature for the specified time and the completion of the reaction is judged by TLC analysis. The reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to obtain a crude residue which was purified by conventional silica gel column chromatography using ethyl acetate-petroleum ether as mobile phase to obtain compound 11b.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(2-Hydroxyethyl)methacrylamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Thadke, Shivaji A.; Kar, Mritunjoy; Gupta, Sayam Sen; Hotha, Srinivas; Carbohydrate Research; vol. 346; 12; (2011); p. 1511 – 1518;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics