Category: 50509-09-6

The author of 《Psychotropic drugs. 18. Synthesis and structure-activity relations of 5-phenyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-ones》 were Nakanishi, Michio; Tahara, Tetsuya; Araki, Kazuhiko; Shiroki, Masami; Tsumagari, Tatsumi; Takigawa, Yukio. And the article was published in Journal of Medicinal Chemistry in 1973. Category: amides-buliding-blocks The author mentioned the following in the article:

Several thienodiazepinones showed central nervous depressant activity in mice comparable to that of diazepam. One of the most active compounds, 5-o-fluorophenyl-7-ethyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-one (I) [41191-07-5], inhibited fighting at 0.4 mg/kg orally and counteracted the lethal effects of pentetrazole at 0.3 mg/kg i.p. Some compounds, including I, also showed anticonvulsant, muscle-relaxant, and narcotic-potentiating activity in mice and a taming effect in olfactory bulbectomized rats. To synthesize I, o-fluoro-ω-cyanoacetophenone [31915-26-1] was condensed with butyraldehyde [123-72-8] and powd. S in DMF-NEt3 to form 2-amino-3-o-fluorobenzoyl-5-ethylthiophene [41191-09-7], converted to 2-chloroacetamido-3-o-fluorobenzoyl-5-ethylthiophene [41191-10-0] by reaction with ClCH2COCl, then to the iodoacetamido compound by exchange with NaI and to the aminoacetamido compound with NH3 gas, and cyclized by refluxing in pyridine-AcOH-C6H6. In the experiment, the researchers used 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6Category: amides-buliding-blocks)

2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vejdelek, Zdenek; Rajsner, Miroslav; Svatek, Emil; Holubek, Jiri; Protiva, Miroslav published their research in Collection of Czechoslovak Chemical Communications on December 31 ,1979. The article was titled 《Benzocycloheptenes and heterocyclic analogs as potential drugs. XIV. Synthesis of 7-chloro-5-(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-2-(methylamino)-3H-1,4-benzodiazepine 4-oxide and of some related compounds》.Safety of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide The article contains the following contents:

The base-catalyzed condensation of 4-ClC6H4NO2 with 2-(cyanomethyl)-6,7,8,9-tetrahydro-5H-benzocycloheptene afforded the 2,1-benzisoxazole derivative I, which was reduced with Fe in AcOH to the ketone II. Its oxime was treated with ClCH2COCl in AcOH and gave 6-chloro-2-(chloromethyl)-4-(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)quinazoline 3-oxide. Treatment with MeNH2 in MeOH led to the substitution reaction with a simultaneous ring enlargement and the title compound III was formed. A similar reaction with 1-methylpiperazine proceeded without rearrangement resulting in the quinazoline derivative IV. III and IV were devoid of anticonvulsant activity. 7-Chloro-5-(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-1,3-dihydro-1,4-benzodiazepin-2-one (mol. complex with II), 6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl 3′-(4-ethoxycarbonyl 4-phenylpiperidino)propyl ketone (an analog of pethidine devoid of analgetic activity), and intermediates useful in the synthesis of 5-(2-chlorophenyl)-7-ethyl-1,3-dihydrothieno[2,3-e]-1,4-diazepin-2-ones were also prepared In the experiment, the researchers used 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6Safety of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide)

2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Safety of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamideOn March 31, 1984, Polivka, Zdenek; Holubek, Jiri; Svatek, Emil; Metys, Jan; Protiva, Miroslav published an article in Collection of Czechoslovak Chemical Communications. The article was 《Potential hypnotics and anxiolytics: synthesis of 2-bromo-4-(2-chlorophenyl)-9-[4-(2-methoxyethyl)piperazino]-6H-thieno[3,2-f]-1,2,4-triazolo[4,3-a]-1,4-diazepine and of some related compounds》. The article mentions the following:

Title compounds I (R = MeO, EtO, MeS, n = 2; R = MeO, n = 3) were prepared by alkylation of thienotriazolodiazepine II (R1 = R2 = Br) with substituted piperazines. I (R = PhO, PhS, n = 2) were prepared by alkylation of I (R1 = piperazino, R2 = Br). Cyclization of hydrazinothienodiazepine III with ClC(OEt)3 gave II (R1 = R2 = H), which could only be brominated to give I (R1 = Br, R2 = H). Some intermediates were prepared for the synthesis etizolam. I had less anticonvulsant activity than 8-chloro-6-(2-chlorophenyl)-1-piperazino-4H-s-triazolo[4,3-a]-1,4-benzodiazepines. The results came from multiple reactions, including the reaction of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide)

2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fun, Hoong-Kun; Chantrapromma, Suchada; Dayananda, A. S.; Yathirajan, H. S.; Ramesha, A. R. published their research in Acta Crystallographica, Section E: Structure Reports Online on February 29 ,2012. The article was titled 《2-Amino-N-[3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl]acetamide》.COA of Formula: C15H15ClN2O2S The article contains the following contents:

In the title compound, C15H15ClN2O2S, the 2-aminoacetamide N-C(=O)-C-N unit is approx. planar, with an root-mean-square deviation of 0.020(4) Å. The central thiophene ring makes dihedral angles of 7.84(11) and 88.11(11)°, resp., with the 2-aminoacetamide unit and the 2-chloropenyl ring. An intramol. N-H···O H bond generates an S(6) ring motif. In the crystal, mols. are linked by an N-H···O H bond and weak C-H···O interactions into a chain along the c axis. A C-H···π interaction is also present. Crystallog. data and at. coordinates are given. The results came from multiple reactions, including the reaction of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6COA of Formula: C15H15ClN2O2S)

2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.COA of Formula: C15H15ClN2O2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamideOn September 30, 2014 ,《Crystal structure of N-[3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl]-2-[(E)-(2-hydroxybenzylidene)amino]acetamide》 was published in Acta Crystallographica, Section E: Structure Reports Online. The article was written by Kaur, Manpreet; Jasinski, Jerry P.; Kavitha, Channappa N.; Yathirajan, Hemmige S.; Byrappa, K.. The article contains the following contents:

In the title compound, C22H19ClN2O3S, the dihedral angle between the mean planes of the thiophene ring and the chlorophenyl and hydroxyphenyl rings are 70.1(1) and 40.2(4)°, resp. The benzene rings are twisted with respect to each other by 88.9(3)°. The imine bond lies in an E conformation. Intramol. O-H···N and N-H···O H bonds each generate S(6) ring motifs. In the crystal, weak C-H···O interactions link the mols., forming chains along the c axis and zigzag chains along the b axis, generating sheets lying parallel to (100). Crystallog. data and at. coordinates are given. The results came from multiple reactions, including the reaction of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide)

2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics