Related Products of 50494-42-3On November 1, 2021 ,《Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Matsingos, Christos; Al-Adhami, Taha; Jamshidi, Shirin; Hind, Charlotte; Clifford, Melanie; Mark Sutton, J.; Rahman, Khondaker Miraz. The article conveys some information:
Antimicrobial resistance and lack of new antibiotics to treat multidrug-resistant (MDR) bacteria is a significant public health problem. There is a discovery void and the pipeline of new classes of antibiotics in clin. development is almost empty. Therefore, it is important to understand the structure activity relationships (SAR) of current chem. classes as that can help the drug discovery community in their efforts to develop new antibiotics by modifying existing antibiotic classes. We studied the SAR of the C5-acylaminomethyl moiety of the linezolid, an oxazolidinone antibiotic, by synthesizing 25 compounds containing various aromatic, heteroaromatic and aliphatic substitutions. Our findings suggest that this position is highly important for the function of this antibiotic class, since only smaller non-polar fragments are tolerated at this position while larger and polar ones lead to a decrease in activity compared to linezolid. Our findings have led us to construct a structure activity relationship, around the C5-acylaminomethyl moiety of linezolid, that provides valuable insight into the function of the oxazolidinone class of antibiotics. In the experimental materials used by the author, we found Cyclopent-3-enecarboxamide(cas: 50494-42-3Related Products of 50494-42-3)
Cyclopent-3-enecarboxamide(cas: 50494-42-3) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Related Products of 50494-42-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics