Category: 489-17-8

Anilkumar, Gopinadhan N. published the artcileII. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides, COA of Formula: C7H8FNO2S, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(1), 713-717, database is CAplus and MEDLINE.

Development of SAR at the C2 position of indole lead I, a palm site inhibitor of HCV NS5B polymerase (NS5B IC₅₀ = 0.053 μM, replicon EC₅₀ = 4.8 μM), is described. Initial screening identified an acyl sulfonamide moiety as an isostere for the C2 carboxylic acid group. Further SAR investigation resulted in identification of acyl sufonamide analog II (NS5B IC₅₀ = 0.039 μM, replicon EC₅₀ = 0.011 μM) with >100-fold improved replicon activity.

Bioorganic & Medicinal Chemistry Letters published new progress about 489-17-8. 489-17-8 belongs to amides-buliding-blocks, auxiliary class Fluoride,Sulfamide,Amine,Benzene, name is 4-Fluoro-2-methylbenzenesulfonamide, and the molecular formula is C7H8FNO2S, COA of Formula: C7H8FNO2S.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Palmisano, Giovanni published the artcileElectrochemical heterocyclization of o-toluenesulfonamides to 3-alkyl-4,5-dihydro-1,2,4-benzothiadiazepine 1,1-dioxides, Application In Synthesis of 489-17-8, the publication is Tetrahedron (1988), 44(5), 1545-52, database is CAplus.

Controlled potential oxidation of a variety of substituted o-toluenesulfonamides at a Pt anode in MeCN using a divided cell forms 3-methyl-4,5-dihydro-1,2,4-benzothiadiazepine-1,1-dioxides selectively and in generally good yields. The scope and limitations of this 1-step heterocyclization sequence are also discussed.

Tetrahedron published new progress about 489-17-8. 489-17-8 belongs to amides-buliding-blocks, auxiliary class Fluoride,Sulfamide,Amine,Benzene, name is 4-Fluoro-2-methylbenzenesulfonamide, and the molecular formula is C7H8FNO2S, Application In Synthesis of 489-17-8.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics