Category: 4815-28-5

Adding a certain compound to certain chemical reactions, such as: 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4815-28-5, Recommanded Product: 4815-28-5

General procedure: 1 mmol of 5-(2-thienyl)-3-isooxazol carboxylic acid and TEA (3 mmol) were stirred in 2,5 ml of anhydrous DCM. The mixture was cooled down to 0 C and 1.3 mmol of DIC was added in several portions. The mixture was stirred for 15 min and 1.33 mmol Hobt was added at once. The stirring was continued for half an hour and 1 mmol of glycine tert-butyl ester hydrochloride was added to the mixture. The reaction was warmed to RT and stirred overnight. The mixture was diluted with 15 ml of DCM and the organic layer was washed with 0.1 M hydrochloric acid solution and distilled water. The organic layer was dried over anhydrous Na2SO4 end evaporated under reduced pressure. The crude product was purified by column chromatography (n-hexane: chloroform). Yield white needles 60 %. 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide (1mmol) and tert-butyl ({[5-(2-thienyl)-3-isooxazol]carbonyl}amino) acetic acid (1 mmol) were treated as described for compound STK2 [8] The crude product was collected by filtration and purified by crystallization from ethyl acetate with addition of methanol yielding 42 % of desired product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, and friends who are interested can also refer to it.

Reference:
Article; Tomala, Marcin D.; Magiera-Mularz, Katarzyna; Kubica, Katarzyna; Krzanik, Sylwia; Zieba, Bartosz; Musielak, Bogdan; Pustula, Marcin; Popowicz, Grzegorz M.; Sattler, Michael; Dubin, Grzegorz; Skalniak, Lukasz; Holak, Tad A.; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 261 – 267;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 4815-28-5, The chemical industry reduces the impact on the environment during synthesis 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of 2-amino-4, 5, 6, 7-tetrahydrobenzo[b]thiophene-3-carboxamide 1b (1.0 mmol), ketones 2 (1.0 mmol) and InCl3 (10%, w/w) in acetonitrile (6 mL) was stirred at room temperature for the time indicated in Table. After completion of the reaction (indicated by TLC) the reaction mixture was filtered to remove the insoluble catalyst and wash with acetonitrile (2 X 5mL). The filtrate was collected and concentrated under vacuum. The solid isolated was triturated in MTBE (10 mL), filtered and dried to give the desired product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ismail; Kuthati, Bhaskar; Thalari, Gangadhar; Bommarapu, Venkatesham; Mulakayala, Chaitanya; Chitta, Suresh Kumar; Mulakayala, Naveen; Bioorganic and Medicinal Chemistry Letters; vol. 27; 6; (2017); p. 1446 – 1450;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 4815-28-5, The chemical industry reduces the impact on the environment during synthesis 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of 2-amino-4, 5, 6, 7-tetrahydrobenzo[b]thiophene-3-carboxamide 1b (1.0 mmol), ketones 2 (1.0 mmol) and InCl3 (10%, w/w) in acetonitrile (6 mL) was stirred at room temperature for the time indicated in Table. After completion of the reaction (indicated by TLC) the reaction mixture was filtered to remove the insoluble catalyst and wash with acetonitrile (2 X 5mL). The filtrate was collected and concentrated under vacuum. The solid isolated was triturated in MTBE (10 mL), filtered and dried to give the desired product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ismail; Kuthati, Bhaskar; Thalari, Gangadhar; Bommarapu, Venkatesham; Mulakayala, Chaitanya; Chitta, Suresh Kumar; Mulakayala, Naveen; Bioorganic and Medicinal Chemistry Letters; vol. 27; 6; (2017); p. 1446 – 1450;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 4815-28-5,Some common heterocyclic compound, 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, molecular formula is C9H12N2OS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide(4a;1.5 mmol) was suspended in 10 ml butanol and benzaldehydes(5a-5m;1.0 mmol). Conc HCl (0.1 ml) was added to this reaction mixture and heated at 80 C for 12 h or until TLC confirms the completion of reaction. The solid obtained was filtered, washedwith water and dried.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, its application will become more common.

Reference:
Article; Amawi, Haneen; Karthikeyan, Chandrabose; Pathak, Rekha; Hussein, Noor; Christman, Ryann; Robey, Robert; Ashby, Charles R.; Trivedi, Piyush; Malhotra, Ashim; Tiwari, Amit K.; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 1053 – 1065;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 4815-28-5, The chemical industry reduces the impact on the environment during synthesis 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of 2-amino-4, 5, 6, 7-tetrahydrobenzo[b]thiophene-3-carboxamide 1b (1.0 mmol), ketones 2 (1.0 mmol) and InCl3 (10%, w/w) in acetonitrile (6 mL) was stirred at room temperature for the time indicated in Table. After completion of the reaction (indicated by TLC) the reaction mixture was filtered to remove the insoluble catalyst and wash with acetonitrile (2 X 5mL). The filtrate was collected and concentrated under vacuum. The solid isolated was triturated in MTBE (10 mL), filtered and dried to give the desired product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ismail; Kuthati, Bhaskar; Thalari, Gangadhar; Bommarapu, Venkatesham; Mulakayala, Chaitanya; Chitta, Suresh Kumar; Mulakayala, Naveen; Bioorganic and Medicinal Chemistry Letters; vol. 27; 6; (2017); p. 1446 – 1450;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4815-28-5 as follows. Product Details of 4815-28-5

General procedure: 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide(4a;1.5 mmol) was suspended in 10 ml butanol and benzaldehydes(5a-5m;1.0 mmol). Conc HCl (0.1 ml) was added to this reaction mixture and heated at 80 C for 12 h or until TLC confirms the completion of reaction. The solid obtained was filtered, washedwith water and dried.

According to the analysis of related databases, 4815-28-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Amawi, Haneen; Karthikeyan, Chandrabose; Pathak, Rekha; Hussein, Noor; Christman, Ryann; Robey, Robert; Ashby, Charles R.; Trivedi, Piyush; Malhotra, Ashim; Tiwari, Amit K.; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 1053 – 1065;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 4815-28-5,Some common heterocyclic compound, 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, molecular formula is C9H12N2OS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 2-aminothiophene derivatives 1a-c (0.01 mol) in 7.2 mL conc. HCl and 4 mL H2O was stirred and cooled in ice bath. Then, a solution of NaNO2 (0.690 g,0.01 mol) in 8 mL H2O was added dropwise for 10 min. The cold diazonium solution was added slowly to awell-stirred solution of 3-iminobutanenitrile (0.82 g, 0.01mol) or 1-phenyl-2-thiocyanatoethanone (1.78 g, 0.01mol), in ethanol (60 mL) containing sodium acetate (4 g, 0.05 mol). The reaction mixture was stirred for another3 h. The formed precipitate was filtered off, dried well, and recrystallized from ethanol/benzene to give 3a-c and 7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, its application will become more common.

Reference:
Article; Gouda, Moustafa A.; Eldien, Hadeer Fakhr; Girges, Margret M.; Berghot, Moged A.; Indian Journal of Heterocyclic Chemistry; vol. 28; 3; (2018); p. 401 – 405;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

To a stirred solution of the appropriate aminothiophene (1 equiv. ) in 1,4-dioxane (5ml per mmol of aminothiophene) was added the appropriate acyl chloride (1.2 equiv. ). The reaction mixture was stirred at room temperature for 17 hours and then diluted with ether or hexane. The resultant precipitate was removed by filtration, washed with ether and air- dried to give the desired product. Compound No. 390 of Table 14 Using the additional general procedure 2- (2-chloroacetylamino)-4, 5,6, 7-tetrahydro- benzo [b] thiophene-3-carboxylic acid amide (Compound No. 390 of Table 14) was obtained from aminothiophene WO as an off-white solid in 52% yield. m. p. 242-245C (dec.).

The synthetic route of 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED; WO2005/44008; (2005); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 4815-28-5,Some common heterocyclic compound, 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, molecular formula is C9H12N2OS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 492-(2-(3-(trifluoromethyl)-4,5,6,7-tetrahydroindazole-1-yl)propanamido)-4,5,6,7- tetrahydrobenzorithiophene-3-carboxamide a) 2-(3-chloropropanamido)-4,5,6,7-tetrahydrobenzo[]thiophene-3-carboxamide2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (250 mg, 1.28 mmol) and triethylamine (0.18 ml_, 1.28 mmol) were stirred in DCM (5 ml_). 3-chloropropionylchloride (162 mg, 1.28 mmol) was added dropwise under a nitrogen atmosphere. Stirring was continued for 2 h. 2 M HCI (20 ml_) was added and the reaction mixture extracted into DCM (3 x 50 ml_), The combined DCM layers were washed with brine, dried over MgSO4, filtered and the solvent removed in vacuo to give the desired product as a yellow solid (290 mg, 1.01 mmol, 79 %).1 H NMR (400MHz, CDCI3): delta 1.86 (m, 4H), 2.72 (m,4H), 2.91 (t,2H), 3.86 (t, 2H), 5.73 (s, 2H), 12.1 (s,1 H).

The synthetic route of 4815-28-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; N.V. ORGANON; WO2008/3452; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics