Category: 478837-18-2

Adding a certain compound to certain chemical reactions, such as: 478837-18-2, name is tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 478837-18-2, HPLC of Formula: C12H21NO3

tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1 ]octane-8-carboxylate as obtained in step 1 (100 mg, 2.0 mmol), acetonitrile (2 mL) and 4 M hydrogen chloride in 1,4-dioxane (2 mL) were combined and stirred at 700C for 15 minutes. The reaction mixture was concentrated and dried to give 8-azabicyclo[3.2.1]octan-3-ol hydrochloride salt (71 mg, 100% yield). MS (EI) for C7H13NO: 128 (MH+).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; EXELIXIS, INC.; AAY, Naing; BLAZEY, Charles, M.; BOWLES, Owen, Joseph; BUSSENIUS, Joerg; CURTIS, Jeffry, Kimo; DEFINA, Steven, Charles; DUBENKO, Larisa; HARRIS, Jason, R.; JACKSON-UGUETO, Eileen, E.; KIM, Angie, Inyoung; MANALO, Jean-claire, Limun; PACK, Michael; PETO, Csaba, J.; RICE, Kenneth, D.; TSANG, Tsze, H.; WANG, Longcheng; WO2010/138490; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 478837-18-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 478837-18-2 name is tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of tert-butyl 3-hydroxy-8-azabicyclo [3.2.1] octane-8-carboxylate (2 g, 8.80 mmol) and triethylamine (1.84 mL, 13.20 mmol) in dichloromethane (10 mL) Was added and stirred at 0 C, methanesulfonyl chloride (0.817 mL, 10.56 mmol) was added and reacted for 2 hours. The solvent was removed from the resulting mixture under reduced pressure, and the reaction mixture was extracted with dichloromethane (40 mL), dried using anhydrous magnesium sulfate, filtered and the solvent was removed under reduced pressure. The obtained organic layer was purified by silica gel flash column chromatography (ethyl acetate: hexane = 1: 4) to obtain tert-butyl 3- (methylsulfonyloxy) -8-azabicyclo [3.2.1] octane-8-carboxylate 92.4%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; NOH, Eun Joo; SIM, Tae Bo; AHN, Dae Ro; CHOI, Seung Ho; (25 pag.)KR101683061; (2016); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics