Some common heterocyclic compound, 478832-21-2, name is tert-Butyl 4-hydroxyazepane-1-carboxylate, molecular formula is C11H21NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of tert-Butyl 4-hydroxyazepane-1-carboxylate
To a solution of tert-butyl 4-hydroxyazepane-i-carboxylate (3.0 g, 14.0 mmol, 1.0 equiv.) and N,N-diisopropylethylamine (3.2 mL, 18.0 mmol, 1.3 equiv.) in (1574) dichloromethane (70 mL) was added methanesulfonyl chloride (1.2 mL, 15.0 mmol, 1.1 equiv.). The reaction mixture was stirred at room temperature for 1 hour and then water was added. The organic layer was separated and then washed twice with water, once with brine, dried over sodium sulfate, filtered and concentrated in vacuo to give the title compound (3.87 g, 95 %). (1575) NMR (CDC13) delta 4-97 – 4-76 (m, 1 H), 3.62 – 3.24 (m, 4 H), 3.00 (s, 3 H), 2.14 – 1.83 (m, 4 H), 1.68 (q, 2 H), 1.45 (s, 9 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 478832-21-2, its application will become more common.
Reference:
Patent; INFLAZOME LIMITED; COOPER, Matthew; MILLER, David; MACLEOD, Angus; VAN WILTENBURG, Jimmy; THOM, Stephen; ST-GALLAY, Stephen; SHANNON, Jonathan; (352 pag.)WO2019/8025; (2019); A1;,
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