Category: 4746-61-6

《Solubility and partitioning. I: Solubility of nonelectrolytes in water》 was written by Yalkowsky, Samuel H.; Valvani, Shri C.. HPLC of Formula: 4746-61-6 And the article was included in Journal of Pharmaceutical Sciences on August 31 ,1980. The article conveys some information:

Semiempirical anal. gave an equation that enables the estimation of the aqueous solubility of either liquid or crystalline organic nonelectrolytes: log Sw ≈ -1.00 log PC – 1.11[ΔSf(MP-25)/1364] + 0.54 where log PC and ΔSf are estimated from the chem. structure and MP is either known or exptl. determined Anal. of this equation provides a means of assessing the role of crystal structure [as reflected by the m.p. (MP) and the entropy of fusion (ΔSf)] and of the activity coefficient [as reflected by the octanol-water partition coefficient (PC)] in controlling the aqueous solubility of a drug. Techniques are also provided for estimating the entropy of fusion of organic compounds In the experiment, the researchers used many compounds, for example, 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6HPLC of Formula: 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.HPLC of Formula: 4746-61-6 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Hydrogen-bonding one-dimensional arrangement in the crystal of N-phenyl-2-hydroxyacetamide》 was written by Perpetuo, Genivaldo Julio; Janczak, Jan. Application of 4746-61-6 And the article was included in Journal of Molecular Structure on August 27 ,2009. The article conveys some information:

The N-phenyl-2-hydroxyacetamide was obtained in crystalline form by a direct reaction of aniline with glycolic acid. The whole mol. in the crystal is nonplanar, but the planar 2-hydroxyacetamide group is inclined by 7.8(1)° to the plane of the Ph ring that is cis located to the carbonyl oxygen atom. The hydroxyl group is in trans position to the carbonyl oxygen atom. The mols. are linked by the N-H···O and O-H···O hydrogen bonds into 1-dimensional chains along the a-axis. Addnl., the C-H···π interactions interconnect the chains stabilizing the crystal structure. The x-ray geometry of the N-phenyl-2-hydroxyacetamide mol. was compared with that obtained by the ab-initio MO calculated results that represents the geometry in the gas-phase. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Application of 4746-61-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Introduction of the amide function into 1,3,2-dioxaphospholenes with pentavalent phosphorus》 was published in Journal of the American Chemical Society in 1970. These research results belong to Ramirez, Fausto; Bauer, J.; Telefus, C. David. Application In Synthesis of 2-Hydroxy-N-phenylacetamide The article mentions the following:

Carbamoyl-1,3,2-dioxaphospholenes with pentavalent P were synthesized from α-oxo aldehydes, isocyanates, and trialkyl phosphites. The phospholenes were converted into phosphate esters of β-oxo-α-hydroxyamides. These underwent rapid hydrolyses to β-oxo-α-hydroxyamides. The experimental process involved the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application In Synthesis of 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Application In Synthesis of 2-Hydroxy-N-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 1995,Journal of Chemical Research, Synopses included an article by Casadei, Maria Antonietta; Cesa, Stefania; Inesi, Achille; Moracci, Franco Micheletti. Application of 4746-61-6. The article was titled 《Electrochemical studies on haloamides. Part 11. Electrocarboxylation of carboxamides》. The information in the text is summarized as follows:

The electroreduction of C2-unsubstituted and C2-mono- and -di-substituted haloacetamides XCR1R2CONHR3 (X = Br, Cl, R1, R2 = H, Me, R3 = PhCH2, Ph), carried out in dipolar aprotic solvents and in the presence of CO2, yields synthetically used malonamates R4O2CCR1R2CONHR3 (R4 = Me, Bu) following in situ alkylation. In the experiment, the researchers used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Application of 4746-61-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Kinetics and mechanism of reversible, base-catalyzed ring closure of 3-(methoxycarbonyl)propionanilide and (methoxycarbonyl)methyl N-phenylcarbamate》 was written by Kavalek, Jaromir; Machacek, Vladimir; Svobodova, Gabriela; Sterba, Vojeslav. Formula: C8H9NO2 And the article was included in Collection of Czechoslovak Chemical Communications on April 30 ,1989. The article conveys some information:

The rate constants of reversible, base-catalyzed ring closure of 3-(methoxycarbonyl)propionanilide (I) and (methoxycarbonylmethyl) phenylcarbamate (II) to 1-phenyl-2,5-pyrrolidinedione (III) and 3-phenyl-2,4-oxazolidinedione (IV), resp., and the rates of solvolyses of III and IV in water and methanol have been determined In both cases, an equilibrium is established between the starting ester and the cyclization product in methoxide solutions, which is strongly shifted in favor of the starting ester. In the case of II in methoxide solutions, the cyclization is followed by a much slower splitting of the cyclization product to give glycolic acid anilide. The effects of X = NH, CH2, O, S in RNHCOXCH2COOMe on the rates of the cyclization and solvolysis of the cyclization products is discussed.2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Formula: C8H9NO2) was used in this study.

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Formula: C8H9NO2 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics