Category: 4746-61-6

The author of 《Oxidation of acetanilides to glycolanilides and oxanilic acids in rabbits》 were Kiese, Manfred; Lenk, Werner. And the article was published in Biochemical Pharmacology in 1969. Recommanded Product: 4746-61-6 The author mentioned the following in the article:

In the urine of rabbits injected with various acetanilides, the corresponding glycol-anilides were found. Approx. 5% of the given acetanilides appeared in the urine as 4-chloroglycolanilide, 4-bromoglycolanilide and 4-propionylglycolanilide. They were isolated and their structures were established by uv, ir and N.M.R. spectra. Less than 1% of acetanilide and phenacetin were excreted as glycolanilides. No 4-propylglycolanilide was found in the urine after the administration of 4-propylacetanilide. The effect of various substituents in the 4-position on the biochem. hydroxylation of AcOH in acetanilides is discussed. Rabbits given 4-chloroacetanilide or 4-propionylacetanilide excrete several per cent as the corresponding oxanilic acids. In addition to this study using 2-Hydroxy-N-phenylacetamide, there are many other studies that have used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Recommanded Product: 4746-61-6) was used in this study.

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.Recommanded Product: 4746-61-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hauser, Melanie R.; Zhakarov, Lev; Doxsee, Kenneth M.; Li, Tonglei published their research in Crystal Growth & Design on December 31 ,2008. The article was titled 《Polymorphism of a Simple Organic Amide》.Category: amides-buliding-blocks The article contains the following contents:

Glycolanilide (2-hydroxy-N-phenylacetamide), a simple amide, may be reproducibly crystallized in either of two polymorphic forms. The crystal and mol. structures of each polymorph have been determined, revealing that the two polymorphs differ in the extent and arrangement of intermol. hydrogen bonding. The more stable polymorph displays one-dimensional chains linked through hydrogen bonds between the amide carbonyl and the α-hydroxyl group. In the metastable polymorph, analogous chain structures are overlain with cyclic hydrogen-bonded amide dimers, with an addnl. set of hydrogen bonding contacts joining the chain and cyclic motifs. The experimental process involved the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Category: amides-buliding-blocks)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 1999,Journal of Molecular Modeling included an article by Wang, Jiansuo; Lai, Luhua; Tang, Youqi. HPLC of Formula: 4746-61-6. The article was titled 《Data mining of toxic chemicals: structure patterns and QSAR》. The information in the text is summarized as follows:

The authors take a two-step strategy to explore non-congeneric toxic chems. from the database RTECS: the screening of structure patterns and the generation of a detailed relationship between structure and activity. An efficient similarity comparison is proposed to screen chem. patterns for further QSAR anal. Then CoMFA study is carried out on one structure pattern as an example of the implementation, and the result shows that QSAR studies of structure patterns can provide an estimate of the activity as well as a detailed relationship between activity and structure. From the performance of overall procedure, such a stepwise scheme is demonstrated to be feasible and effective to mine a database of toxic chems.2-Hydroxy-N-phenylacetamide(cas: 4746-61-6HPLC of Formula: 4746-61-6) was used in this study.

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.HPLC of Formula: 4746-61-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 4746-61-6On October 31, 1982 ,《Regioselectivity of enzymic O-dealkylation of simple analogs of cholecystographic constrast media》 was published in Drug Metabolism and Disposition. The article was written by Shono, Tatsuya; Ohmizu, Yohko; Toda, Toshiki; Oshino, Nozomu. The article contains the following contents:

The metabolites of N,N’-diphenyl-α,ω-polyoxyethylenedicarboxamides following O-dealkylation by rat liver microsomes were identified by high-performance liquid chromatog. The pattern of metabolism of the dicarboxamides followed the same O-dealkylation pattern as that of iotroxic acid. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Application of 4746-61-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Mild Access to N-Formylation of Primary Amines using Ethers as C1 Synthons under Metal-Free Conditions》 were Mutra, Mohana Reddy; Dhandabani, Ganesh Kumar; Wang, Jeh-Jeng. And the article was published in Advanced Synthesis & Catalysis in 2018. Application of 4746-61-6 The author mentioned the following in the article:

A new synthetic protocol for the synthesis of N-formamide derivatives HC(O)NHR1 [R1 = C6H5, 3-ClC6H4, 3-NO2C6H4, etc.] was developed via N-formylation of primary amines using ethers as a C1 synthon under metal-free reaction conditions. The reaction was proceeded through C-H functionalization, C-O cleavage and C-N bond formation. Mechanistic studies disclosed that the reaction proceeds through a radical pathway. Synthesis of amino ethanones PhNHCH(R4)C(O)R2 [R2 = C6H5, 3-MeC6H4, 4-BrC6H4; R3 = tetrahydrofuran-2-yl, 1,4-dioxan-2-yl] were developed via α-alkylation of α-amino ketones with ethers. By replacing dioxane with Tetramethylethylenediamine (TMEDA) under standard conditions also gave the N-formamide derivatives HC(O)NHR1 in moderate yields. After reading the article, we found that the author used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.Application of 4746-61-6 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Efficient Copper(II)-Catalyzed Transamidation of Nonactivated Primary Carboxamides and Ureas with Amines》 was written by Zhang, Min; Imm, Sebastian; Baehn, Sebastian; Neubert, Lorenz; Neumann, Helfried; Beller, Matthias. Synthetic Route of C8H9NO2 And the article was included in Angewandte Chemie, International Edition in 2012. The article conveys some information:

A copper(II) catalyzed transamidation process using nonactivated primary carboxamides and ureas with amines is presented. For this technique, the Cu(OAc)2 is fairly inexpensive and convenient to use without special precautions. Fortunately, a wide range of amides, ureas, chiral amines can be synthesized from primary carboxamides and amines in good to excellent yields. By extension this protocol can be applied to the synthesis of amides, peptide, polyamides and heterocycles. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Synthetic Route of C8H9NO2)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Synthetic Route of C8H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2011,Angewandte Chemie, International Edition included an article by Zhang, Min; Imm, Sebastian; Baehn, Sebastian; Neumann, Helfried; Beller, Matthias. Recommanded Product: 2-Hydroxy-N-phenylacetamide. The article was titled 《Synthesis of α-amino acid amides: ruthenium-catalyzed amination of α-hydroxy amides》. The information in the text is summarized as follows:

An efficient ruthenium-catalyzed amination of α-hydroxy acid derivatives is reported. Using a variety of amines, including anilines, primary and secondary aliphatic amines, and ammonia, a wide range of amino acid amides was obtained from α-hydroxy amides or esters. Combination of Ru3(CO)12 and 1,2-bis(dicyclohexylphosphino)ethane was the best catalyst system. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Recommanded Product: 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Recommanded Product: 2-Hydroxy-N-phenylacetamide In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 4746-61-6On October 30, 2014 ,《Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives》 was published in European Journal of Medicinal Chemistry. The article was written by Hung, Joy M.; Arabshahi, Homayon J.; Leung, Euphemia; Reynisson, Johannes; Barker, David. The article contains the following contents:

Forty seven thieno[2,3-b]pyridine-2-carboxamides, furo[2,3-b]pyridine-2-carboxamides, tetrahydrothieno[2,3-b]quinolone-2-carboxamides and their derivatives were synthesized and tested for their antiproliferative activity against the NCI-60 cell lines. The tetrahydrothieno[2,3-b]quinolone-2-carboxamides I (R = Ph, 4-MeOC6H4, 3-BrC6H4, 3,5-Cl2C6H3, etc.) were found to have the greatest activity, with the compound I (R = 3-MeOC6H4) being the most active, with GI50 values in the low nanomolar range against a range of cell lines, in particular the melanoma cell line MDA-MD-435 (GI50 – 23 nM) and the breast cancer cell line MDA-MB-468 (GI50 – 46 nM). Mol. modeling of series I against phosphoinositide specific-phospholipase C revealed that the side chains of the amino acids His356, Glu341, Arg549 and Lys438 are involved in hydrogen bonding with the ligands as well as a lipophilic pocket is occupied by the Ph carboxamide moiety. After reading the article, we found that the author used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Product Details of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Product Details of 4746-61-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Peng, Tian-Yu; Xu, Zhe-Yuan; Zhang, Feng-Lian; Li, Bin; Xu, Wen-Ping; Fu, Yao; Wang, Yi-Feng published an article in Angewandte Chemie, International Edition. The title of the article was 《Dehydroxylative Alkylation of α-Hydroxy Carboxylic Acids Derivatives via a Spin-Center Shift》.Application In Synthesis of 2-Hydroxy-N-phenylacetamide The author mentioned the following in the article:

A strategically distinct dehydroxylative alkylation reaction of α-hydroxy carboxylic acid derivatives I (Ar1 = 4-NCC6H4, 4-EtO2CC6H4, 2-pyridyl, etc.) with alkenes is developed. The reaction starts with the attack of a 4-dimethylaminopyridine (DMAP)-boryl radical to the carbonyl oxygen atom, followed by a spin-center shift (SCS) to trigger the C-O bond scission. The resulting α-carbonyl radicals couple with a wide range of alkenes to furnish various alkylated products II (Ar1 = 4-NCC6H4, 4-EtO2CC6H4, 2-pyridyl, etc.; R = n-Bu, Ph, 3-MeC6H4, etc.) . This strategy allows for the efficient conversion of a wide array of α-hydroxy amides and esters derived from several biomass mols. and natural products to value-added compounds Exptl. and computational studies verified the reaction mechanism. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application In Synthesis of 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Application In Synthesis of 2-Hydroxy-N-phenylacetamide In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Relative stabilities of glycolanilide and thioglycolanilide chelates》 were Apte, K. P.; Bhattacharya, A. K.. And the article was published in Journal of Inorganic and Nuclear Chemistry in 1973. Quality Control of 2-Hydroxy-N-phenylacetamide The author mentioned the following in the article:

Equilibrium constants were determined by pH titrations for complexation of H+ and M3+ (M = Al, Cr) with L (LH = glycolanilide, thioglycolanilide). In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Quality Control of 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Quality Control of 2-Hydroxy-N-phenylacetamide In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics