Category: 4746-61-6

Khalaj, A.; Nahid, E. published their research in Synthesis on December 31 ,1985. The article was titled 《Synthesis of α-hydroxy carboxamides from acetonides of α-hydroxy carboxylic acids and primary amines》.SDS of cas: 4746-61-6 The article contains the following contents:

Acetonides I (R = H, Me, Ph; R1 = H, Ph) were treated with R2NH2 (R2 = Pr, Ph, 4-O2NC6H4, 2-pyridyl) to give 30-78% HOCRR1CONHR2 (13 compounds). The reactions were performed by heating in a H2O bath without solvent, in refluxing C6H6 or PhMe or in xylene in a sealed tube at 200°. The experimental process involved the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6SDS of cas: 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.SDS of cas: 4746-61-6 In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: 2-Hydroxy-N-phenylacetamideOn September 23, 2015 ,《Vilsmeier reagent initialed sequential one-pot multicomponent synthesis of N,O-disubstituted glycolamides as dipeptidyl peptidase 4 inhibitors》 was published in Tetrahedron. The article was written by Lu, Shi-Han; Yen, Wan-Ping; Tsai, Henry J.; Chen, Chien-Shu; Wong, Fung Fuh. The article contains the following contents:

A series of N,O-disubstituted glycolamide derivatives have been successfully synthesized through Vilsmeier reagent initialed sequential one-pot multicomponent procedure from α-chloro N-arylacetamides with formamide/PBr3 and acid chloride. The three-step synthesis involved Vilsmeier formyloxylation reaction, decarbonylation, and esterification. The strategy was also applicable to α-chloro N-(naphthalenyl)acetamide to prepare the corresponding N,O-disubstituted glycolamide products. All of N,O-disubstituted glycolamides were evaluated against dipeptidyl peptidase 4 inhibitory activity. Based on the inhibitory results, several of O-furan-2-carbonyl and O-quinoline-8-sulfonyl N-aryl glycolamide compounds possessed the better effective inhibition of dipeptidyl peptidase 4. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Name: 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Name: 2-Hydroxy-N-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Metabolism of N-acylated and O-alkylated drugs by intestinal microflora during anaerobic incubation in vitro》 were Smith, G. E.; Griffiths, L. A.. And the article was published in Xenobiotica in 1974. COA of Formula: C8H9NO2 The author mentioned the following in the article:

Phenacetin [62-44-2] and derivatives of acetanilide were N-deacylated by rat cecal microflora, the deacylation of the latter being dependent on the nature and position of the substituents. Thus, p-alkylated or o-, m-, or p-hydroxylated derivatives were deacylated, whereas a p-aromatic or halide substituent or an aromatic acyl grouping prevented deacylation. A few O-alkylated compounds with a simple benzenoid structure were dealkylated by cecal microflora, but none of the N-alkylated drugs were dealkylated. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6COA of Formula: C8H9NO2)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.COA of Formula: C8H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Shutao; Gao, Yongliang; Song, Shaoli; Li, Xinze; Zhang, Zhuoqi; Xiang, Jinbao; Zheng, Lianyou published their research in Tetrahedron on August 13 ,2022. The article was titled 《Lewis base catalyzed allylation reaction of N-aryl amides with Morita-Baylis-Hillman carbonates》.Synthetic Route of C8H9NO2 The article contains the following contents:

A Lewis base catalyzed allylation reaction of N-aryl amides with various Morita-Baylis-Hillman (MBH) carbonates was described. The substrate scope of MBH carbonates and amides were comprehensively explored. The broad substrate scope, mild condition, as well as scale-up synthesis made this approach useful for the synthesis of diversified branched tertiary N-allylic amides.2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Synthetic Route of C8H9NO2) was used in this study.

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.Synthetic Route of C8H9NO2 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hutson, D. H.; Lakeman, S. K.; Logan, C. J. published their research in Xenobiotica on December 31 ,1984. The article was titled 《The fate of 4-cyano-N,N-dimethylaniline in rats; a novel involvement of glutathione in the metabolism of anilines》.Quality Control of 2-Hydroxy-N-phenylacetamide The article contains the following contents:

4-Cyano-N,N-dimethylaniline (CDA)(I) [1197-19-9], when administered to rats as a single oral dose (18.5 mg/kg), was rapidly absorbed and eliminated as a mixture of metabolites in the urine (86% dose after 24 h). Residues in tissues after 48 h, expressed as μg equivalent of CDA, were: liver, 0.35; kidney, 0.28; testes, 0.08; fat 0.06; bone marrow, 0.15; and blood, 0.32. Absorption, metabolism, and elimination following 4 consecutive daily doses of CDA (65 mg/kg) were similar to those at the lower dose. The major metabolite was 2-amino-5-cyanophenyl sulfate (II) [95774-25-7] with its mono- [95774-26-8] and di-N-methyl-II  [95774-27-9] analogs as minor metabolites. 4-Cyanoaniline (III) [873-74-5], N-acetyl-III  [35704-19-9], and an unstable derivative were also found as metabolites. Three S-containing metabolites (IV) [95774-28-0], (V) [92510-57-1], and (VI) [92510-56-0] were identified, the latter accounting for 10.3% and 4.1% of the low and high doses, resp. The S-containing metabolites indicate the involvement of glutathione  [70-18-8] in metabolism at the N-acetyl group. This implies the generation of an electrophilic intermediate, possibly the sulfate conjugate of a N-glucolylaniline, in the metabolism of CDA. The results came from multiple reactions, including the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Quality Control of 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.Quality Control of 2-Hydroxy-N-phenylacetamideAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《A tandem coupling/Smiles rearrangement/cyclization approach to 1,4-benzoxazinone or 1,4-pyridooxazinones under mild conditions》 were Zhan, Chunjing; Jia, Jiong; Yang, Bingchuan; Huang, Aiping; Liu, Yanli; Ma, Chen. And the article was published in RSC Advances in 2012. Related Products of 4746-61-6 The author mentioned the following in the article:

A facile and efficient approach to 1,4-benzoxazinone or 1,4-pyridooxazinone scaffolds is developed by a Smiles rearrangement tandem reaction. 1,4-Benzoxazinone derivatives or 1,4-pyridooxazinone derivatives with diversity at two substituents on their scaffolds were synthesized conveniently in the presence of cesium carbonate at room temperature in good to excellent yields. The reaction mechanism is assumed by a tandem coupling/Smiles rearrangement/cyclization process. The synthesis of the target compounds was achieved using fluoro(nitro)benzene derivatives and chloro(nitro)benzene derivatives and 2-hydroxyacetamide derivatives as starting materials. The title compounds thus formed included 3,4-dihydro-3-oxo-4-phenyl-2H-1,4-benzoxazine-7-carbonitrile (I), 4-(phenylmethyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (II), 5-chloro-4-(phenylmethyl)-2H-1,4-benzoxazin-3(4H)-one (III) and related substances. The experimental process involved the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Related Products of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Related Products of 4746-61-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 2-Hydroxy-N-phenylacetamideOn May 31, 2008, Gomez, Maria J.; Sirtori, Carla; Mezcua, Milagros; Fernandez-Alba, Amadeo R.; Agueera, Ana published an article in Water Research. The article was 《Photodegradation study of three dipyrone metabolites in various water systems: Identification and toxicity of their photodegradation products》. The article mentions the following:

The photochem. behavior of 3 relevant metabolites of the analgesic and antipyretic drug dipyrone, 4-methylaminoantipyrine (4-MAA), 4-formylaminoantipyrine (4-FAA) and 4-acetylaminoantipyrine (4-AAA), was evaluated under simulated solar irradiation (Suntest system). For 4-MAA, different aqueous solutions (synthetic seawater, freshwater and Milli-Q water) as well as different operational conditions were compared. According to the exptl. results, 4-MAA resulted as being an easily degraded mol. by direct photolysis, with half-life times (t1/2) ranging from 0.12 to 0.58 h, depending on the irradiation conditions. Faster degradation was observed in synthetic waters, suggesting that the photolysis was influenced by the salt composition of the waters. However, no effect on the degradation rate was observed by the presence of natural photosensitizers (dissolved organic matter, nitrate ions). 4-FAA and 4-AAA showed slower photodegradation kinetics, with t1/2 of 24 and 28 h, resp. A study of photoproduct identification was carried out by gas chromatog.-mass spectrometry (GC-MS) and liquid chromatog.-time-of-flight mass spectrometry (LC-TOF-MS) (ESI pos. mode), which allowed us to propose a tentative photodegradation pathway for 4-MAA and the identification of persistent byproducts in all the cases. The application of an acute toxicity test (Daphnia magna) showed an increase in toxicity during the photolytic process, a consequence of the formation of toxic photoproducts. The results came from multiple reactions, including the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Recommanded Product: 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Recommanded Product: 2-Hydroxy-N-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 1986,Tetrahedron Letters included an article by Shin, Jai Moo; Kim, Yong Hae. Computed Properties of C8H9NO2. The article was titled 《New facile synthesis of α-hydroxy amides: intermolecular and intramolecular catalysis in the reaction of α-hydroxy carboxylic acids with N-sulfinylamines》. The information in the text is summarized as follows:

α-Hydroxy carboxylic acids reacted with N-sulfinylanilines to give the corresponding α-hydroxy anilides in quant. yields under mild condition. The reaction appeared to involve intermol. catalysts by the carboxylic acid moiety and intramol. catalysis by the HO group. Thus, DL-mandelic acid in MeCN treated with PhN:S:O gave 100% DL-mandelanilide.2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Computed Properties of C8H9NO2) was used in this study.

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.Computed Properties of C8H9NO2 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Heteroatom Chemistry included an article by Chiang, Kun-Heng; Lu, Shi-Han; Yen, Wan-Ping; Uramaru, Naoto; Tseng, Wei-Siou; Chang, Te-Wei; Wong, Fung Fuh. Synthetic Route of C8H9NO2. The article was titled 《Effective Synthesis of N-Arylformamide from α-Halo-N-arylacetamides》. The information in the text is summarized as follows:

A convenient synthetic method for N-arylformamide derivatives was successfully developed by reacting α-iodo-N-arylacetamides with formamide [e.g., α-iodo-N-phenylacetamide + HCONH2 → N-phenylformamide (94%)]. This method was applicable to α-iodo-N-arylacetamide substrates bearing electron-donating or electron-withdrawing groups, N-(benzo[d][1,3]dioxol-5-yl)-2-iodoacetamide, 2-iodo-N-(pyridin-2-yl)acetamide, and 2-iodo-N-(naphthalen-4-yl)acetamide to give the corresponding N-arylformamides in moderate to excellent yields (65-94%). A plausible mechanism was proposed to account for the new transformation. In addition to this study using 2-Hydroxy-N-phenylacetamide, there are many other studies that have used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Synthetic Route of C8H9NO2) was used in this study.

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.Synthetic Route of C8H9NO2Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Development of carboxylic acid search prefilters for spectral library matching》 was published in Microchemical Journal in 2012. These research results belong to Lavine, Barry K.; Nuguru, Kadambari; Mirjankar, Nikhil; Workman, Jerome. Quality Control of 2-Hydroxy-N-phenylacetamide The article mentions the following:

435 IR absorbance spectra of 140 carboxylic acids and 295 noncarboxylic acids which included aldehydes, ketones, esters, amides as well as compounds containing both carbonyls and alcs. were preprocessed using the wavelet packet tree to enhance subtle but important features in the data. Wavelet coefficients that optimized the separation of the spectra by functional group in a plot of the two largest principal components of the data were identified using a genetic algorithm (GA) for pattern recognition anal. Because principal components maximize variance, the bulk of the information encoded by the wavelet coefficients selected by the pattern recognition GA is characteristic of the carboxylic acid functional group. The carboxylic acid search prefilter developed as part of this study was successfully validated using two external validation sets. The 1st validation set consisted of 24 carboxylic acids and 61 noncarboxylic acids and the 2nd validation set consisted of 264 carboxylic acids and 72 noncarboxylic acids. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Quality Control of 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.Quality Control of 2-Hydroxy-N-phenylacetamideAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics