Category: 4563-33-1

Related Products of 4563-33-1, A common heterocyclic compound, 4563-33-1, name is Phenylmethanesulfonamide, molecular formula is C7H9NO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 63; N-[benzylsulfonyl]-2-[4-[1-(1-(2-(1-piperidinyl)phenyl)pentyl)aminocarbonylmethyl]phenoxy]-2-methylpropanamide; This compound was obtained by condensation between compound 10 and phenylmethanesulfonamide according to protocol L. It was purified by silica gel chromatography (dichloromethane/methanol 98/2). Yield: 39%

The synthetic route of 4563-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENFIT; US2006/79696; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 4563-33-1, name is Phenylmethanesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4563-33-1, COA of Formula: C7H9NO2S

(b) tert-Butyl 3-[(benzylsuIfonyI)carbamoyl]azetidine-l-carboxylateTBTU (33.71 g, 105 mmol) and TEA (30.3 g, 300 mmol) was added to a solution of 1- (tert-butoxycarbonyl)azetidine-3-carboxylic acid from above (25.89 g, assumed to contain is 100 mmol) in THF (200 mL) and the reaction was stirred at r.t for 30 minutes. 1- phenylmethanesulfonamide (17.97 g, 105 mmol) and LiCl (1.844 g, 43.5 mmol) was added and the stirring was continued at r.t over night (23 hours). The reaction was concentrated to about 1/3 was left and EtOAc (500 mL) was added and the organic phase was washed with 2 M HCl (1 x 150 mL, 2 x 50 mL), water (2 x 50 mL). Drying (MgSO4), filtration and20 evaporation of the solvent gave a brown powder (48. 6 g). The powder was slurried in 150 mL TBME and stirred 3 hours. The solids was filtered off and washed with TBME (40 mL). This procedure was repeated twice with 100 mL TBME (washing with 25 mL) to give a brownish powder (33 g) still containing some HOBT. The powder was dissolved in about 100 mL warm EtOH and water (130 mL) was added to induce a crystallisation of the25 product. The crystals was filtered off and dried to give pure tert-butyl 3-[(benzylsulfonyl)carbamoyl]azetidine-l-carboxylate as an off white powder. Yield: 25.4 g(71%).1H NMR (400 MHz, DMSO-d6) delta 1.39 (9H, s), 3.30 (IH, m, overlapping with the watersignal in DMSO), 3.78-3.95 (4H, m), 4.73 (2H, s), 7.28-7.34 (2H, m), 7.36-7.41 (3H,30 m), 11.71 (IH, br s). MS m/z: 353 (M-I).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Phenylmethanesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; WO2008/4946; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics