Adding a certain compound to certain chemical reactions, such as: 456-64-4, name is 1,1,1-Trifluoro-N-phenylmethanesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 456-64-4, HPLC of Formula: C7H6F3NO2S
Intermediate 7 (3 g) was dissolved in dimethylformamide (100 mL) and the solution cooled to 0C under nitrogen. Triethylamine (2.3 mL) was added and the stirred solution treated with N-phenyltrifluoromethanesulfonamide (4.83 g). After 30 minutes at 0C the reaction mixture was allowed to reach room temperature and stirred for 72 hours. The reaction mixture was diluted with water (5 ml) and concentrated, treated with water (200 ml) and extracted with ethyl acetate (4x 250 ml). The combined organic extracts were washed with water (2x 250 mL), dried (Na2SO4), filtered, concentrated to dryness and purified by silica gel chromatography, eluting with ethyl acetate/cyclohexane (5:95, 10:90 then 20:80, v/v) to give the title compound.MS calcd for (C30H30F3NO7S + H)+: 620 MS found (electrospray): (M+H)+= 620
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1-Trifluoro-N-phenylmethanesulfonamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/96774; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics