Category: 456-12-2

On March 15, 2007, Narender, T.; Shweta, S.; Tiwari, P.; Reddy, K. Papi; Khaliq, T.; Prathipati, P.; Puri, A.; Srivastava, A. K.; Chander, R.; Agarwal, S. C.; Raj, K. published an article.Category: amides-buliding-blocks The title of the article was Antihyperglycemic and antidyslipidemic agent from Aegle marmelos. And the article contained the following:

The plant Aegle marmelos belongs to the family of Rutaceae. From the leaves of A. marmelos an alkaloidal-amide, Aegeline, was isolated and found to have antihyperglycemic activity as evidenced by lowering the blood glucose levels by 12.9% and 16.9% at 5 and 24 h, resp., in sucrose challenged streptozotocin induced diabetic rats (STZ-S) model at the dose of 100 mg/kg body weight Aegeline 2 has also significantly decreased the plasma triglyceride (Tg) levels by 55% (P < 0.001), total cholesterol (TC) by 24% (P < 0.05), and free fatty acids (FFA) by 24%, accompanied with increase in HDL-C by 28% and HDL-C/TC ratio by 66% in dyslipidemic hamster model at the dose of 50 mg/kg body weight The reasonable mapping of compound 2 to validated pharmacophoric hypothesis and 3D QSAR model with an estimated activity (283 nM) suggest that the compound 2 might be a β3-AR agonist. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to aegle alkaloid aegeline antidyslipidemic antihyperglycemic, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 26, 2021, Singh, Amrit Pal; Singh, Lovedeep; Singh, Palwinder; Bhatti, Rajbir published an article.Product Details of 456-12-2 The title of the article was Biological Evaluation of Aegle marmelos Fruit Extract and Isolated Aegeline in Alleviating Pain-Depression Dyad: In Silico Analysis of Aegeline on MAO-A and iNOS. And the article contained the following:

Pain and depression have been assessed to co-occur in up to 80% of patients, and this comorbidity is more debilitating and pricier for the patients as compared to either of these disorders alone. Aegle marmelos is a well-known medicinal plant with a broad spectrum of pharmacol. activities. Aegeline is a relatively unexplored mol. present in Aegle marmelos. Therefore, the current investigation aims to explore the potential of Aegle marmelos fruit extract (AMFE) and isolated aegeline against the reserpine-induced pain-depression dyad. In the current investigation, aegeline was isolated from AMFE, followed by spectroscopic characterization, i.e., using NMR and mass analyses. AMFE (200 mg kg-1 p.o) and aegeline (10 mg kg-1 p.o.) were administered to reserpinized (0.5 mg kg-1 s.c.) mice, and clorgyline (3 mg kg-1 i.p.) was taken as the standard drug. AMFE and aegeline significantly alleviated the reserpine-induced reduction in a pain threshold and an increase in immobility as observed in behavioral tests of pain and depression, resp. In silico mol. docking studies of aegeline showed a good binding interaction at the active sites of MAO-A and iNOS. The in vivo anal. showed that AMFE and aegeline treatment significantly decreased the monoamine oxidase-A (MAO-A) activity, serum interleukin-6 (IL-6) level, and lipid peroxidation, along with an increase in the reduced glutathione level in comparison to the reserpine-treated group. Immunofluorescence studies also showed that AMFE and aegeline abrogated the reserpine-induced increase in iNOS expression. Conclusively, the results delineate that AMFE and aegeline might exert a protective effect via downregulating the MAO-A hyperactivity, IL-6 level, oxidative and nitrosative stress. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Product Details of 456-12-2

The Article related to pain depression aegle marmelos aegeline amfe docking inos maoa, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Product Details of 456-12-2

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On January 20, 2012, Bhupatbhai, Bagatharia Snehal; Kamleshkumar, Joshi Chinmayi; Mahavirsaran, Saxena Akshaykumar published a patent.Recommanded Product: 456-12-2 The title of the patent was A compound Aegeline inhibiting acetylcholinesterase and a method of screening/identifying the same. And the patent contained the following:

The present invention discloses a compound Aegeline inhibiting acetylcholinesterase using a method of screening/identifying the same for treatment of CNS disorders. The structure of Aegeline is developed with the help of a computer application MDL ISIS Draw. The crystal structure of the acetylcholinesterase is retrieved from the Research Collaborator for Structural Bioinformatics (RSCB) Protein Data Bank (PDB) and prepared by energy minimization, assigning bond orders and optimization of the structure. The screening method utilizes the 3D structure of the target protein acetylcholinesterase binding site to prioritize compounds (ligands) by their likelihood to bind to the said protein. The actual free energy is referred as a score and the highest score denotes more preferable compound for acetylcholinesterase. In comparison with the conventional drugs, at the binding site of acetylcholinesterase, Aegeline proves be more effective and can help in the treatment of memory-related disorders. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: 456-12-2

The Article related to aegeline acetylcholinesterase inhibitor screening cns disorder treatment, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 456-12-2

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On March 15, 2019, Raheja, Shikha; Girdhar, Amit; Kamboj, Anjoo; Lather, Viney; Pandita, Deepti published an article.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Aegle marmelos leaf extract ameliorates the cognitive impairment and oxidative stress induced by intracerebroventricular streptozotocin in male rats. And the article contained the following:

Therefore, the present study was attempted to investigate the neuroprotective potential of ethanolic extract of A. marmelos leaves (AME) on STZ induced memory impairment in male rats. Albino Wistar rats were pre-treated orally with AME at the doses 200 and 400 mg/kg for two weeks, followed by intracerebroventricular (i.c.v.) injection of STZ (3 mg/kg) on day 1 and 3. Two weeks after STZ administration, behavioral parameters were monitored using Morris water maze task. Biochem. and histopathol. studies were carried out after three weeks of STZ administration. The levels of oxidative stress markers (malondialdehyde (MDA), glutathione, nitrite, catalase) neuroinflammatory mediators; tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) and acetylcholinesterase (AChE) activity were estimated in hippocampus of rat brain. Donepezil (5 mg/kg) was taken as a standard drug. The levels of MDA, nitrite, TNF-a and IL-6 were significantly increased while glutathione levels were significantly decreased in hippocampus of STZ-treated rats. Further, a significant decrease in the activity of catalase and increase in AChE activity was observed indicating cholinergic hypofunction and neuronal damage in STZ-treated animals. All these alterations were significantly ameliorated by AME in a dose dependent manner. The neuroprotective potential of A. marmelos against STZ induced oxidative stress and cognitive deficit in rats indicates its therapeutic value in Alzheimer’s disease (AD). The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle leaf aegeline neuroprotectant oxidative stress, a. marmelos, alzheimer’s disease, memory impairment, oxidative stress, streptozotocin, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
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On February 1, 2019, Derf, Asma; Sharma, Ankita; Bharate, Sandip B.; Chaudhuri, Bhabatosh published an article.Computed Properties of 456-12-2 The title of the article was Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. And the article contained the following:

Herein, we have identified yeast Sec22p (ySec22p), a SNARE protein essential for endoplasmic reticulum to Golgi trafficking, as a suppressor of Bax-induced yeast apoptosis and corroborated published observations that ySec22p suppresses α-synuclein’s toxicity in yeast. It has been suggested that compounds which enhance expression, in neurons, of human homologues of ySec22p (Sec22Bp/Sec22p/Sec22A) would prevent synucleinopathies, such as Parkinson’s disease. With the aim of finding a small mol. that would mimic ySec22p, a library of natural products consisting of 394-compounds was screened using yeast cells that express either human α-synuclein or human Bax. The antioxidant aegeline, an alkaloid-amide occurring in the leaves of the plant Aegle marmelos Correa, was the only mol. that overcame apoptosis induced by both α-synuclein and Bax in yeast. Besides, aegeline also prevented growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells. These results highlight the importance of yeast systems to identify rapidly mols. that may prevent the onset of apoptosis that occurs in Parkinson’s disease. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

The Article related to aegeline apoptosis ros sec22p mitochondrial membrane potential, aegeline, apoptosis, dna-fragmentation, mitochondrial-membrane-potential, ros, sec22p, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Computed Properties of 456-12-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 16, 1980, Swinehart, Jacquelyn A.; Stermitz, Frank R. published an article.HPLC of Formula: 456-12-2 The title of the article was Constituents of Zanthoxylum. Part 4. Bishordeninyl terpene alkaloids and other constituents of Zanthoxylum culantrillo and Z. coriaceum. And the article contained the following:

Thin-layer chromatog. and NMR, UV, and mass spectrometry revealed the new alkaloid, culantraramine (I), in Z. culantrillo stems, together with (+)-eudesmin, (-)-epieudesmin, hordenine, (-)-N-methyliscorydine, magnoflorine, candicine, skimmianine, synephrine, tembetarine, and a dihydroxydimethoxytetrahydroprotoberberine. Isolated from Z. coriaceum were (-)-N-methylisocorydine, dihydrochelerythrine, chelerythrine, N-methylcanadine, (±)-aegeline, and (±)-alfileramine (II). The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2

The Article related to zanthoxylum bishordeninyl terpene alkaloid structure, culantraramine zanthoxylum structure, Alkaloids: Alkaloids Containing Two Nitrogen Atoms In A Simple Combination Of Those Found In Subsections 2, 3, and 4 and other aspects.HPLC of Formula: 456-12-2

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Amide – an overview | ScienceDirect Topics

Somanathan, Ratnasamy; Aguilar, Hugo R.; Ventura, G. Rodriguez; Smith, Kevin M. published an article in 1983, the title of the article was Syntheses of natural hydroxyamides using trimethylsilyl cyanide.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Addition of Me3SiCN to p-anisaldehyde gave 64% p-MeOC6H4CH(CN)OSiMe3, which was reduced to give p-MeOC6H4CH(OH)CH2NH2 (I). Acylation of I with RCOCl gave 77-92% tembamide (I, R = Ph), aegeline (I, R = styryl), and I [R = 3-pyridyl, Me(CH2)7]. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to silyl cyanide synthetic reagent, hydroxyamide naturally occurring, amide hydroxy naturally occurring, tembamide aegeline, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2009, Shyamala, M.; Arulanantham, A. published an article.Category: amides-buliding-blocks The title of the article was Aegle marmelos as effective corrosion pickling inhibitor on mild steel in hydrochloric acid. And the article contained the following:

In this study, the corrosion inhibition effect of aqueous extract of Aegle marmelos in 1N hydrochloric acid has been investigated by weight loss, gasometric, potentiodynamic polarization and impedance methods. The Aegle marmelos was found to be effective corrosion pickling inhibitor. The effect of immersion time revealed that the extracts of Aegle marmelos has maximum inhibition efficiency of 97.5 % in presence of an optimum concentration of 8 % volume/volume of the extract at 3 h of immersion time. Similarly, in gasometric method, maximum efficiency was found to be 97.1 % in the same optimum concentration It was confirmed by potentiodynamic polarization and impedance methods, which showed a maximum efficiency of 97.5 % and 96.6 % resp. in the concentration 8 % in volume/volume Potentiodynamic polarization studies indicated that the plant extract behaves as mixed type inhibitor. The adsorption of Aegle marmelos follows Langmuir adsorption isotherm. The inhibition action is due to presence of the alkaloid aegeline in the leaves of Aegle marmelos. The protective film formed on the surface of the mild steel was confirmed by SEM studies. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to hydrochloric acid mild steel corrosion pickling inhibitor aegle marmelos, Ferrous Metals and Alloys: Corrosion (If The Primary Interest Is In The Metal), Erosion, Cavitation, Tribology, and Oxidation and other aspects.Category: amides-buliding-blocks

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mohammed, Magdy M. D.; Ibrahim, Nabaweya A.; El-Sakhawy, Fatma S.; Mohamed, Khaled M.; Deabes, Doaa A.-H. published an article in 2016, the title of the article was Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Two new cytotoxic furoquinoline alkaloids were isolated from the leaves of Aegle marmelos (Linn.) Correa; one from the total alkaloidal fraction (acid/base shake-out method) of the CHCl3 extract and identified as 7,8-dihydroxy-4-hydrofuroquinoline and named trivially as Aegelbine-A. The other new alkaloid isolated from the pet. ether extract and identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline and named trivially as Aegelbine-B, together with a known alkaloid; aegeline and a known phenolic acid; ρ-hydroxybenzoic acid. The structures of all the isolated compounds were established based on 1D and 2D NMR spectroscopy and HR-ESI/MS. The cytotoxic activity of the isolated compounds was evaluated in vitro against HepG-2, PC3, A549 and MCF-7 cell lines. The obtained results revealed promising activity with structure-based relationship which is discussed briefly. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to mol structure cytotoxic furoquinoline alkaloid aegle aegelbine human antitumor, aegle marmelos (linn.) correa, cytotoxicity, furoquinoline alkaloids, rutaceae, structure–activity relationship studies and other aspects.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gogoi, Bhaskarjyoti; Gogoi, Dhrubajyoti; Gogoi, Neelutpal; Mahanta, Saurov; Buragohain, Alak K. published an article in 2022, the title of the article was Network pharmacology based high throughput screening for identification of multi targeted anti-diabetic compound from traditionally used plants.Category: amides-buliding-blocks And the article contains the following content:

The incurable Type 2 diabetes mellitus (T2DM) has now been considered a pandemic with only supportive care in existence. Due to the adverse effects of available anti-diabetic drugs, there arises a great urgency to develop new drug mols. One of the alternatives that can be considered for the treatment of T2DM are natural compounds from traditionally used herbal medicine. The present study undertakes, an integrated multidisciplinary concept of Network Pharmacol. to evaluate the efficacy of potent anti-diabetic compound from traditionally used anti-diabetic plants of north east India and followed by DFT anal. In the course of the study, 22 plant species were selected on the basis of their use in traditional medicine for the treatment of T2DM by various ethnic groups of the north eastern region of India. Initially, a library of 1053 compounds derived from these plants was generated. This was followed by network preparation between compounds and targets based on the docking result. The compounds having the best network property were considered for DFT anal. We have identified that auraptene, a monoterpene coumarin for its activity in the management of Type 2 diabetes mellitus and deciphered its unexplored probable mechanisms. Mol. dynamics simulation of the ligand-protein complexes also reveals the stable binding of auraptene with the target proteins namely, Protein Kinase C θ, Glucocorticoid receptor, 11-β hydroxysteroid dehydrogenase 1 and Aldose Reductase, all of which form uniform interactions throughout the MD simulation trajectory. Therefore, this finding could provide new insights for the development of a new anti-diabetic drug. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to traditional plant antidiabetic compound high throughput screening network pharmacol, type 2 diabetes mellitus, insulin resistance, natural products, network pharmacology, traditional knowledge and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics