Category: 456-12-2

Narender, T.; Rajendar, K.; Sarkar, S.; Singh, V. K.; Chaturvedi, Upma; Khanna, A. K.; Bhatia, G. published an article in 2011, the title of the article was Synthesis of novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolylethyl)-amide derivatives and their antidyslipidemic and antioxidant activity.SDS of cas: 456-12-2 And the article contains the following content:

In continuation of a program on metabolic diseases, the alkaloidal amide aegeline (I) from Aegle marmelos leaves was identified as a dual acting agent (antihyperlipidemic and antihyperglycemic). Therefore, a series of alkaloidal amides [N-(2-hydroxy-2-p-tolylethyl)-amides and N-(2-oxo-2-p-tolylethyl)-amide derivatives] related to aegeline was synthesized and screened in vivo in rats for antihyperlipidemic activity in Triton induced hyperlipidemia model. The synthetic compounds II, (E)-Me-4-C6H4CH(OH)CH2NHCOCH:CHC6H3-4-OH-3-OMe and Me-4-C6H4CH(OH)CH2NHCOCH2R (R = 3-pyridinyl) showed equipotent activity to the natural product, i.e., aegeline. These compounds also showed strong antioxidant activity, which support their antihyperlipidemic activity. Me-4-C6H4COCH2NHCO(CH2)2R (R = 3-pyridinyl) showed better antihyperlipidemic and antioxidant profile than the natural product I. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).SDS of cas: 456-12-2

The Article related to aegeline alkaloid amide derivative synthesis antihyperglycemic antidyslipidemic antioxidant activity, Alkaloids: Alkaloids Containing One Nitrogen Atom Not In A Ring and other aspects.SDS of cas: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2013, Mustahil, N. A.; Riyanto, S.; Sukari, M. A.; Rahmani, M.; Mohd nor, S. M.; Ali, A. M. published an article.Related Products of 456-12-2 The title of the article was Antileukemic activity of extracts and constituents of Aegle marmelos. And the article contained the following:

Phytochems. study of various parts of Aegle marmelos (leaves, stem bark and roots) have afforded eleven compounds; hopane and lupane triterpenes including zeorin (1), dustanin (2) also epilupeol (3) and lupenone (4); alkaloids aegeline (5) and skimmianine (6); coumarin derivatives; auraptene (7), epoxyauraptene (8) and marmin (9) together with β-sitosterol and stigmasterol. All crude extracts and isolated compounds were examined for their antileukemic activity against CEM-SS Qmman T-lymphoblastic leukemia cancer cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Roots extracts exhibited significant cytotoxicity while leaves and stem bark extracts were inactive. Hopane triterpenes; zeorin (1) and dustanin (2) as well as alkaloid aegeline (5) isolated from leaves exhibited moderate to strong cytotoxicity with dustanin (2) as the most active constituent (IC50 : 5.3 ± 0.24 μg/mL). Lupane triterpenes; epilupeol (3) and lupenone (4), in addition of coumarin derivative; marmin (9) isolated from stem bark also demonstrated moderate to strong cytotoxicity with epilupeol (3) showed significant activity (IC50 : 6.1 ± 0.20 μg/mL). The chem. constituents isolated from roots were inactive except for epilupeol (3) and marmin (9) which have also been isolated from stem bark. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to zeorin lupane leaf stem bark root aegle antileukemic, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Related Products of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2011, Nugroho, Agung Endro; Riyanto, Sugeng; Sukari, Mohamad Aspollah; Maeyama, Kazutaka published an article.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Effects of aegeline, a main alkaloid of Aegle marmelos correa leaves, on the histamine release from mast cells. And the article contained the following:

Aegeline or N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide is a main alkaloid isolated from Aegle marmelos Correa collected in Yogyakarta Indonesia. In our study, we investigated the effects of aegeline on the histamine release from mast cell. The study was performed by using (1) rat basophilic leukemia (RBL-2H3) cell line, and (2) rat peritoneal mast cells (RPMCs). DNP24-BSA, thapsigargin, ionomycin, compound 48/80 and PMA were used as inducers for histamine release from mast cell. In our study, aegeline inhibited the histamine release from RBL-2H3 cells induced by DNP24-BSA. Indeed, aegeline showed strong inhibition when RBL-2H3 cells induced by Ca2+ stimulants such as thapsigargin and ionomycin. Aegeline is suggested to influence the intracellular Ca2+ pool only since could not inhibit the 45Ca2+ influx into RBL-2H3 cells. Aegeline showed weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin. These findings indicate that aegeline altered the signaling pathway related to the intracellular Ca2+ pool in which thapsigargin acts. Based on the results, the inhibitory effects of aegeline on the histamine release from mast cells depended on the type of mast cell and also involved some mechanisms related to intracellular Ca2+ signaling events via the same target of the action of thapsigargin or downstream process of intracellular Ca2+ signaling in mast cells. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to antihistamine aegeline alkaloid aegle leaf histamine release mast cell, Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 25, 2007, Yu, Xuhui; Ge, Hongyan; Zhang, Lei; Song, Han; Yu, Ying; Wang, Yuhong published an article.Synthetic Route of 456-12-2 The title of the article was Expressions of IL-12 and IL-18 in patients with acute optic neuritis before and after methylprednisolone pulse therapy. And the article contained the following:

The expressions of interleukin-12 (IL-12) and interleukin-18 (IL-18) and the relationship between IL-12 and IL-18 in acute optic neuritis (AON) before and after methylprednisolone pulse therapy (MPPT) were investigated. ELISA was employed to determine the expressions of IL-12 and IL-18 in serum in 27 patients with AON before and after MPPT. RT-PCR anal. was employed to demonstrate the expressions of IL-12 and IL-18 receptors in peripheral lymphocytes. The serum level of IL-12 was decreased from (45.6±12.2) ng/L to (17.1±4.7) ng/L after MPPT (P < 0.01), and that of IL-18 was decreased from (157.5±39.3) ng/L to (126.2±22.6) ng/L (P < 0.05). The expression of IL12R mRNA was decreased after MPPT too (0.2948 vs. 0.1507, P < 0.05), and so was that of IL18R mRNA (0.5352 vs. 0.2843, P < 0.05). The expressions of IL-12 and IL-18 as well as those of their receptors were pos. correlated. Methylprednisolone could exert its important antiphlogistic action against AON by inhibiting the expressions of the proinflammatory cytokines, IL-2 and IL-18. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Synthetic Route of 456-12-2

The Article related to interleukin il12 il18 optic neuritis methylprednisolone antiinflammatory, Mammalian Hormones: Corticosteroid, Gonadal, and Placental Hormones and other aspects.Synthetic Route of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mala, S. Kumar; Priya, Antony P.; Bincy, Baby; Nazeem, P. A. published an article in 2015, the title of the article was Bioactive compounds to target anti apoptotic proteins- Bcl 2 and Bcl XL an in silico approach.Formula: C18H19NO3 And the article contains the following content:

Phytochems. from several herbaceous and spice plants have been reported to have defense properties against various diseases. Potential of some of such plants like Allium sativum, Curcuma longa, Boerhaavia diffusa, Pterocarpus marsupium and Zingiber officinale in cancer therapy has already been proved. The state of Kerala in southern India hosts large number of medicinal herbs and is also referred as a hotspot of biodiversity. The current study aimed at computational screening of potent lead mols. from ten selected medicinal plants and five spices widely used in Kerala, which are rich in biol. diversity and its traditional values. Even though, the anticancer properties of all these plants and spices were reported, their mode of action and target mols. is not well explained. Hence, the interaction of these compounds with anti-apoptotic proteins Bcl-2 and Bcl-XL are studied and discussed in this paper. The -CDOCKER energy, -CDOCKER interaction energy, Hydrogen bonds, binding energy, and complex energy were predicted through mol. docking studies. Based on binding energy and CDOCKER scores, the active components of Pterocarpus marsupium, Aegle marmelos, Pseudarthira viscida, Allium sativum, Phyllanthus amarus, Boerhaavia diffusa and Catharanthus roseus were observed to have strong interaction with both the proteins. Pharmacokinetic anal. such as absorption, solubility, BBB penetration, and toxicity were also performed for these compounds Comparative docking anal. showed higher interaction than the known inhibitors such as Obatoclax and apogossypolone. Finally, the lead mols. were screened based on their hepatotoxicity. Ten of them passed the anal. and some with high binding energy failed to do so. The lead mols. identified and their probable functional groups could be further reported to transform them as potential anti-apoptotic inhibitors. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Formula: C18H19NO3

The Article related to allium curcuma boerhaavia biol diversity, bioactive compound anti apoptotic protein india, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Formula: C18H19NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Siddique, Nadeem Ahmad; Mujeeb, Mohd.; Najmi, Abul Kalam; Aftab, A.; Aslam, Junaid published an article in 2011, the title of the article was Free radical scavenging and hepatoprotective activity of Aegle marmelos (Linn.) corr leaves against carbon tetrachloride.Related Products of 456-12-2 And the article contains the following content:

Aegle marmelos L. belongs to the family Rutaceae; an important medicinal plant being used in the folk therapy. It is the most useful medicinal plant of India. Its medicinal properties have been described in the ancient medical literature. All parts of the tree (stem, bark, root, leaves and fruit at all stages of maturity) have medicinal virtues and have been used as medicine for a long time. A number of chem. constituents have been isolated from various plant parts including alkaloids, coumarin and steroids. The leaves contain skimianinc, sterol and aegelin. In the present investigation antioxidant and hepatoprotective activity of the methanolic extract of A. marmelos leaves (MEAML) was examined on carbon tetrachloride (CCl4) intoxicated rats. MEAML hold considerable amount of phenolic (9.8367 ± 0.0235 mg/kg) and flavonoid (8.248 ± 0.029 mg/kg) contents, which confirmed the antioxidant property of the leaves. The MEAML with different doses (50, 100, 200 mg/kg body weight) and standard silymarin (40 mg/kg body weight) were orally administered to CCl4 treated rats and the effect was studied on serum enzymes [(aspartate transaminase (AST), alanine transaminase (ALT), alk. phosphatase (ALP), and bilurubin, protein, albumin, thiobarbutiric acid (TBARS), reduced glutathione (GSH)]. In addition, in-vitro antioxidant activity of MEAML was also evaluated using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical. We noticed a significant hepatoprotective activity of MEAML on CCl4 intoxicated rats which support folkloric utilization of A. marmelos, and it was further confirmed by the histol. investigation. The findings of the present investigation revealed that the MEAML possess significant hepatoprotective activity by suppressing CCl4 induced cellular oxidative stress. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to oxidative stress, hepatoprotectant free radical scavenger aegle leaf carbon tetrachloride antioxidant, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Related Products of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 1, 2018, Satish, Sabbu; Srivastava, Ankita; Yadav, Pragya; Varshney, Salil; Choudhary, Rakhi; Balaramnavar, Vishal M.; Narender, Tadigoppula; Gaikwad, Anil Nilkanth published an article.Related Products of 456-12-2 The title of the article was Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells. And the article contained the following:

Excess adiposity is a hallmark of obesity, which is caused due to an imbalance between energy intake and energy consumed. Obesity is often associated with several metabolic disorders like dyslipidemia, cardiovascular diseases and type 2 diabetes. Earlier, the authors’ group had reported natural product Aegeline (amino-alc.) isolated from the plant Aegle marmelos as an anti-diabetic and anti-dyslipidemic compound With this background, the authors synthesized a series of novel amino alc. and thiazolidinedione hybrid mols. and studied their antiadipogenic activity. As a result, the authors have identified a potent hybrid compound (Z)-3-benzyl-5-(4-(3-(3,4-dichlorobenzylamino)-2-hydroxypropoxy)benzylidene)thiazolidine-2,4-dione as an inhibitor of adipocyte differentiation. The compound (Z)-3-benzyl-5-(4-(3-(3,4-dichlorobenzylamino)-2-hydroxypropoxy)benzylidene)thiazolidine-2,4-dione inhibits lipid accumulation and adipogenesis in 3T3-L1 preadipocyte cell line. Exposure of compound (Z)-3-benzyl-5-(4-(3-(3,4-dichlorobenzylamino)-2-hydroxypropoxy)benzylidene)thiazolidine-2,4-dione blocks mitotic clonal expansion and arrests cells in S-phase of cell cycle. Detailed anal. showed that compound (Z)-3-benzyl-5-(4-(3-(3,4-dichlorobenzylamino)-2-hydroxypropoxy)benzylidene)thiazolidine-2,4-dione decreases expression of two major transcription factors that are involved in adipocyte differentiation, PPARγ, C/EBPα, and other adipogenesis associated genes like aP2 and FAS. Thus, compound (Z)-3-benzyl-5-(4-(3-(3,4-dichlorobenzylamino)-2-hydroxypropoxy)benzylidene)thiazolidine-2,4-dione shows potential ability to inhibit adipocyte differentiation which can be used therapeutically for the treatment of obesity and its associated metabolic disorders. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to alc thiazolidinedione hybrid preparation antiadipogenic agent, adipogenesis, obesity, pparγ, thiazolidinedione, β-amino alcohols, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 5, 2015, Gautam, Sudeep; Ishrat, Nayab; Singh, Rohit; Narender, Tadigoppula; Srivastava, Arvind K. published an article.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1. And the article contained the following:

Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus. Here we delineate, aegeline enhanced GLUT4 translocation mediated 2-deoxy-glucose uptake in both time and concentration-dependent manner. 2-deoxy-glucose uptake was completely stymied by the transport inhibitors (wortmannin and genistein) in C2C12 myotubes. Pharmacol. inhibition of Akt (also known as protein kinase B) and Ras-related C3 botulinum toxin substrate 1 (Rac1) suggest that both Akt and Rac1 operate aegeline-stimulated glucose transport via distinct parallel pathways. Moreover, aegeline activates p21 protein-activated kinase 1 (PAK1) and cofilin (an actin polymerization regulator). Rac1 inhibitor (Rac1 inhib II) and PAK1 inhibitor (IPA-3) completely blocked aegeline-induced phosphorylation of cofilin and p21 protein-activated kinase 1 (PAK1). In summary, these findings suggest that aegeline stimulates the glucose transport through Akt and Rac1 dependent distinct parallel pathways and have cytoskeletal roles via stimulation of the PI3-kinase-Rac1-PAK1-cofilin pathway in the skeletal muscle cells. Therefore, multiple targets of aegeline in the improvement of insulin sensitivity of the skeletal muscle cells may be suggested. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegeline antidiabetic aegle leaf extract akt rac1 signaling diabetes, aegeline, aegle marmelos, c2c12 myotubes, cofilin, glucose uptake, insulin resistance, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 15, 2013, Karmase, Aniket; Birari, Rahul; Bhutani, Kamlesh K. published an article.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Evaluation of anti-obesity effect of Aegle marmelos leaves. And the article contained the following:

The study was carried out to investigate the anti-obesity effects of Aegle marmelos leaves extracts and its phytochem. constituents in vitro and in vivo. The dichloromethane (DCM), Et acetate (EtOAc) and n-butanol extracts of A. marmelos leaves were studied for their lipolytic effect. Lipolysis was measured by determining the amount of glycerol released at 12 h and 24 h at 50 μg/mL and 100 μg/mL concentrations Phytochem. investigation of the most active DCM extract yielded 14 compounds The isolated compounds were evaluated for their lipolytic effects at 50 μM and 100 μM. The most active compounds, umbelliferone and esculetin were further screened for their antiobesity effects in vivo in the high fat diet (HFD) induced obese rat model. Umbelliferone and esculetin reduced body weight, total triglyceride (TG), total cholesterol (TC) and glucose level in their resp. HFD groups. A. marmelos DCM extract and compounds isolated from it have the potential of counteracting the obesity by lipolysis in adipocytes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle umbelliferone esculetin antiobesity agents lipolysis obesity, adipocytes, aegle marmelos, anti-obesity, high fat diet, lipolysis, rat model, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gopalan, D. H.; Vani, M.; Manikandan, S.; Vijayakumar, V. published an article in 2021, the title of the article was An immunohistochemical and biochemical evidences of pancreatic β-cell regeneration in type 2 diabetic rats after treated with Aegle marmelos leaf extract and Aegeline.Category: amides-buliding-blocks And the article contains the following content:

The study aims to investigate the Immunohistochem. changes in pancreatic beta cells in fructose fed, streptozocin (STZ) induced Type 2 Diabetes (T2DM) rats treated with various doses of leaf extract of Aegle marmelos (AAM) and Aegeline (AG). 42 adult male wistar albino rats were separated into 7 groups, including Vehicle Control (VC); T2DM; T2DM + AAM 250 mg/kg; T2DM + AAM 500 mg/kg; T2DM + AG 20mg/kg; T2DM + AG 50 mg/kg and T2DM + AG 100 mg/kg. Exptl. T2DM was created by a single dose of 40 mg/kg STZ injection intra-peritoneally along with 10% of fructose solution given orally for 30 days. Calculated dosages of AAM and AG were given with oral gavage for 30 days. Pancreas was harvested and processed. Slides were stained using hematoxylin and eosin (H & E) stains. Insulin expressing beta-cells was analyzed using immunohistochem. Fructose fed, STZ induced rats showed degenerative expressions in beta-cells. In STZ treated rats, AG reduced the blood glucose concentration and serum insulin levels at the maximum functional dose compared to AAM. The immunohistochem. information suggests that the AG at 100 mg/kg dose has the capability of making the dormant cells to reproduce to restore the lost cells of islets of Langerhans. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to diabetics aegle marmelos leaf extract aegeline pancreatic beta cell, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics