Category: 456-12-2

Jaydeep, Chauhan; Harshita, Gupta; Komal, Pandey; Viral, Shah; Bhagyashree, Kamble published an article in 2019, the title of the article was Herbosome an approach to deliver Aegle marmelos extract: Formulation, characterization and stability study.Quality Control of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Aegle marmelos fruit has tremendous potential to treat the various ailments for instance; diabetes, microbial diseases and many more. Despite, having abundant therapeutic activity poor lipid solubility and gastric instability limits the efficacy of Aegle marmelos extract (AME). With an idea to overcome these hurdles, AME was formulated as Herbosome in this study. The concept of Herbosome is gaining popularity, as it provides a sheet of lipid on the outer part of drug or extract, which helps in the bioavailability enhancement. In the present work, AME was prepared by cold extraction method and percentage yield was found to be 20% weight/weight Here, Marmelosin one of the major phytoconstituent in Aegle marmelos, was used as a marker for standardization of the prepared extract Further, preliminary phytochem. screening and thin layer chromatog. (TLC) was carried out. Whereas, quant. estimation of Marmelosin in AME by High-performance thin layer chromatog. (HPTLC) was conducted. In further steps, pre-formulation parameters (effect of several processes and formulation parameters) were studied and Herbosome loaded AME was formulated by conventional technique i.e. thin film method and soyalecithin were used as phospholipids. Several parameters including, percent entrant efficiency (%EE), particle size, polydispersity index (PDI) and zeta-potential were taken into consideration for the evaluation of AME Herbosome. Later on, followed by, In vitro release of optimized formulation was studied and the formulation was able to release up to 92% even after 12 h. After developing successful AME Herbosome, stability study was performed as per the International Conference on Harmonisation (ICH) guidelines up to the period of a month. Herbosome was found to be stable at room temperature, even between 2-4°C. Henceforth, to confirm the efficacy of optimized formulation, In vitro studies (antidiabetic) are going on in the laboratory The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Quality Control of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle herbosome marmelosin phytoconstituent stability, Pharmaceuticals: General and other aspects.Quality Control of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2011, Munigunti, Ranjith; Mulabagal, Vanisree; Calderon, Angela I. published an article.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Screening of natural compounds for ligands to PfTrxR by ultrafiltration and LC-MS based binding assay. And the article contained the following:

In our study, we have screened 133 structurally diverse natural compounds from the MEGx collection of AnalytiCon Discovery and three synthetic hispolone analogs for binding affinity to Plasmodium falciparum thioredoxin reductase (PfTrxR) using an ultrafiltration (UF) and liquid chromatog. (LC/MS) based ligand-binding assay newly developed in our laboratory PfTrxR catalyzes the reduction of thioredoxin (PfTrx) protein. In reduced form, PfTrx is essentially involved in the antioxidative defense and redox regulation of P. falciparum. Nine compounds (yohimbine (1), catharanthine (2), vobasine (3), gnetifolin E (4), quinidine N-oxide (5), 11-hydroxycoronaridine (6), hispolone (7), hispolone Me ether (8), and hernagine (9)) displayed binding affinity for PfTrxR at 1 μM. The ranking order of compound’s binding affinities for PfTrxR is 7 > 6 > 2 > 4 > 5 > 8 > 1 > 9 > 3. On the other hand, compounds 6, 7, 2 and 8 demonstrated specific binding to the active site of PfTrxR, when ligands were tested in an equimolar mixture of 1 μM. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to screening ligand lc ms thioredoxin reductase, Pharmacology: Structure-Activity and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

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Amide – Wikipedia,
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Rawat, Taniya; Uniyal, Sushmita published an article in 2021, the title of the article was A review on phytoconstituents and reported pharmacological activities of rutaceae family plant: Aegle marmelos (L.) correa leaf.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

A review. The only plant in the genus Aegle is bael, a slow-growing, resistant subtropical spiky tree. Family: Rutaceae (Citrus family). It’s also known as wood apple, Bengal quince, golden apple, Indian quince, holy fruit, and stone apple in English. In Sanskrit-Bilwa and in Hindi-Bael, bel. The leaf is one of the plant’s most accumulative sections, holding bioactive substances that are generated as secondary metabolites. Traditionally bael is effective in the treatment of dropsy, diarrhoea, dysentery, and intestinal problems. Phenol, flavonoid, tannin, carbohydrate, sterols, Saponin and alkaloid are all found in leaf extract Skimmianine, Aegeline, lupeol, cineol, eugenol, cuminaldehyde, marmesinine, citronella, and essential oils are isolated compounds from bael. The main components were limonene (82.4%) and (Z)-ocimene (5.1%), which together made up 87.5 percent of the leaf oil. Limonene has been shown to be a useful marker for identifying Aegle marmelos oil samples. Reported pharmacol. studies of A.marmelos leaf extract are Learning and memory, Anxiolytic and Antidepressant, Anticonvulsant, Analgesic, Antipyretic, Anti-inflammatory, Immunomodulatory, hepatoprotective, Cardioprotective, Nephrotoxicity, Antiulcer, Antidiarrhoeal, Antimicrobial, Antiobesity, Anti-proliferative, Antidiabetic, Poly cystic ovarian syndrome, Antithroid activity. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to review aegle phytoconstituent drug, Plant Biochemistry: Reviews and other aspects.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Upadhyay, Ravi Kant published an article in 2015, the title of the article was Bel plant: A source of pharmaceuticals and ethno medicines.Category: amides-buliding-blocks And the article contains the following content:

A review. Bel is a holy native tree of India, which has high ethnomedicinal, therapeutic, and pharmaceutical importance. Bel contains many diverse bioactive components in leaves, flowers, fruits, wood, root, and bark which show multiple biol. activity and high therapeutic importance. Plant contains coumarins, marmelosin, marmesin, imperatorin, marmin, alloimperatorin, Me ether, xanthotoxol, scoparone, scopoletin, umbelliferone, psoralen and marmelide and marmenol, aegelin, aegelenine, marmeline, dictamine, fragrine which show anticancer, antioxidant, antimicrobial, anti-plasmodial, and hepatoprotective activities. Plant possesses various polysaccharides such as galactose, arabinose, uronic acid, and L-rhamnose. Its seed oil contains palmitic, stearic, oleic, linoleic, and linolenic acids which possess very high nutritive value. Plant also possesses very high tannin contents (9%) in fruits, pulp leaves. Tannin found in leaves as skimmianine. Marmelosin, skimmianine, and umbelliferone are therapeutically important active principles. Aegle marmelos is also a good source of gum, wound healers, carotenoids, vitamins, sugars, and nutritive oils. The plant is used to cure digestive disorders, ulcers, headache, hypertension, diabetes, constipation, and numerous other ailments. The ripe fruits are used as a laxative, while unripe Bel fruit, promotes digestion, and cures diarrhea. A. marmelos contains plant essential oil which shows chemotypic and seasonal variations. In the present review article, ethnomedicinal, therapeutic, pharmaceuticals, and insecticidal properties of A. marmelos have been described in detail. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to review aegle leaf flower fruit phytochem pharmaceutical ethno medicine, Plant Biochemistry: Reviews and other aspects.Category: amides-buliding-blocks

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Amide – an overview | ScienceDirect Topics

On May 15, 2014, Geissler, Jacobo Edward; Zhou, Jiang; Jiang, Yang; Zhou, Li published a patent.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the patent was Compositions and methods for affecting mental state and body composition. And the patent contained the following:

Nutritional products and dietary supplements comprise aegeline, consumption of which may result in increased mental stamina, focus, and energy level, improved mood, increased thermogenesis, increased libido, and anabolic effects and increased strength output and(or) muscle mass. The effects may include improved cognition and body composition, with promotion of weight loss, and(or) fitness and well-being. Aegeline may be synthesized by: (a) preparing 2-amino-1-(4-methoxyphenyl)ethanone hydrochloride from 1-(4-methoxyphenyl)ethanone; (b) reacting 2-amino-1-(4-methoxyphenyl)ethanone hydrochloride with cinnamoyl chloride to form N-(2-(4-methoxyphenyl)-2-oxoethyl)cinnamamide intermediate; and (c) reacting the N-(2-(4-methoxyphenyl)-2-oxoethyl)cinnamamide with a reducing agent to form aegeline. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegeline preparation diet supplement mental activity libido muscle strength, Food and Feed Chemistry: Other and other aspects.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pawar, Rahul S.; Grundel, Erich published an article in 2017, the title of the article was Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs).Related Products of 456-12-2 And the article contains the following content:

A review. The multi-billion dollar dietary supplement industry is global in reach. The industry has been criticized for problems related to poor quality control, safety, misbranding, and adulteration. In this review, we describe how the US Food and Drug Administration (FDA) regulates dietary supplements within the framework of the Federal Food, Drug, and Cosmetic Act (FD&C Act). The Dietary Supplement Health and Education Act of 1994 (DSHEA), which amended the FD&C Act, gave the FDA the authority to promulgate Good Manufacturing Practices for dietary supplements and required that manufacturers provide the FDA information supporting a conclusion that the ingredients are reasonably expected to be safe if the dietary ingredients were not marketed in the USA before 15 Oct. 1994. Recent amendments to the FD&C Act require that serious dietary-supplement-related adverse events be reported to the FDA and provide the agency with mandatory recall authority. We discuss the presence of naturally occurring (e.g. Ephedra, Citrus aurantium, Acacia) and synthetic (e.g. β-methylphenethylamines, methylsynephrine, α-ethyl-phenethylamine) biol. active phenethylamines (PEAs) in dietary supplements and of PEA drugs (e.g. clenbuterol, fenfluramine, sibutramine, lorcaserin) in weight-loss products. Regulatory actions against manufacturers of products labeled as dietary supplements that contain the aliphatic amines 1,3-dimethylamine and 1,3-dimethylbutylamine, and PEAs such as β-methylphenethylamine, aegeline, and Dendrobium illustrate the FDA’s use of its authority under the FD&C Act to promote dietary supplement safety. Published 2016. This article is a U. S. Government work and is in the public domain in the USA. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to phenethylamine dietary supplement regulation review, dshea, adulteration, dietary supplements, new dietary ingredient, phenethylamine, Food and Feed Chemistry: Reviews and other aspects.Related Products of 456-12-2

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Amide – an overview | ScienceDirect Topics

On July 17, 2020, Preetha, Bhadra published a patent.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the patent was Biopesticide composition based on bael extract for treating aphids in plant and preparation method thereof. And the patent contained the following:

The invention relates to a biopesticide composition having less harmful side effects for normal cells, and reducing the use of pesticides based on synthetic drugs. The composition contains the following components: 15-25% of aegeline; 15-25% of skimmianine (1); 15-25% of d-limonene; 15-25% of marmelosin and 15-25% of allocryptopine. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to plant aphid bael extract biopesticide composition, Agrochemical Bioregulators: Plant and other aspects.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

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Amide – an overview | ScienceDirect Topics

Kim, Hye Jin; Seo, Young Ju; Htwe, Khin Myo; Yoon, Kee Dong published an article in 2021, the title of the article was Chemical constituents from Aegle marmelos fruits.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Aegle marmelos (Rutaceae) is a deciduous shrub or tree and typically known as bael throughout Southeast Asia and has been used as a medicinal plant and a food ingredient. In this study eight compounds were determined to be O-(3,3-dimethylallyl) halfordinol (1), (R)-aegeline (2), (R)-marmeline (3), imperatorin (4), xanthotoxol (5), valencic acid (6), vanillic acid (7) and rutin (8). The chem. structures of the isolates were elucidated through spectroscopic evidence including 1D, 2D NMR, ESI-Q-TOF-MS and optical rotation. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle marmelos fruit chem constituent, Pharmaceuticals: Pharmacognostic Products and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Priyanka; Joshi, Tushar; Mathpal, Shalini; Chandra, Subhash; Tamta, Sushma published an article in , the title of the article was In silico identification of antidiabetic target for phytochemicals of A. marmelos and mechanistic insights by molecular dynamics simulations.HPLC of Formula: 456-12-2 And the article contains the following content:

The leaves and fruits of Aegle marmelos (L.) have antidiabetic activity. However, the mode of action and mols. having antidiabetic activity are not known. Hence, we conducted mol. docking of phytochems. with various mol. antidiabetic targets to find the same. Docking prioritized Dipeptidyl peptidase-4 (DPP-4) as the main target for phytochems. of Aegle marmelos. DPP-4 inactivates intestinal peptides, glucagon-like peptide-1 (GLP-1), and Gastric inhibitory polypeptide (GIP). GLP-1 and GIP stimulate a decline in blood glucose levels, but DPP-4 inhibits their functions resulting high level of glucose. Hence inhibiting the activity of DPP-4 is a well-known strategy to treat Type 2 diabetes. Therefore, to find a mechanism that may be involved to act as a natural inhibitor of DPP-4, we screened five phytochems. out of seventy-three based on Virtual Screening, ADMET Drug-likeness anal., and PAINS filtering. Further, all five phytochems., i.e. Aegeline, Citral, Marmesinin, Auraptene, β-Bisabolene, and reference compound subjected MDS for analyzing the stability of docked complexes to assess the fluctuation and conformational changes during protein-ligand interaction. The values of RMSD, RG, RMSF, SASA, and Gibbs energy revealed the good stability of these phytochems. in the active site pocket of DPP-4 in comparison to reference Addnl., we have done the pharmacophore anal., which revealed many common pharmacophore features between screened phytochems. of A. marmelos and reference mol. Our results show that these phytochems. are potential antidiabetic candidates and can be further modified and evaluated to develop more effective antidiabetic drugs against DPP-4 to treat Type 2 Diabetes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2

The Article related to aegle marmelos phytochem antidiabetic mol dynamics simulation, aegle marmelos, dpp-4, type 2 diabetes, igemdock, molecular dynamics simulations, Placeholder for records without volume info and other aspects.HPLC of Formula: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Riyanto, Sugeng published an article in 2008, the title of the article was Spectral analysis of aegelin isolated from maja leaves (Aegle marmelos Corr.).Category: amides-buliding-blocks And the article contains the following content:

Aegelin is an alkaloid which isolated from Maja (Aegle marmelos Corr.) leaves. The mol. structure of the compound contains a chiral carbon atom. In our earlier publications the existence and influence of a chiral carbon atom have not been discussed yet. The existing of the chiral carbon atom gave rise two pair of doublets at 未 3.67 J=3.4 Hz and 未 3.43 J=8.5 Hz in the proton NMR spectrum. The doublets are signal of two proton which attached on adjacent atom of the chiral carbon atom which is confirmed by the two dimension NMR spectrum (HMQC). The two protons are magnetic unequivalent which cause their chem. shifts are different. The protons appear as two doublet with different J value because its couple to a proton attached at the chiral carbon atom and the spin-spin splitting is observed The existence of the two pairs of the doublets at 未 3.67 d,J=3.4 Hz and 未 3.42 d,J=8.5 Hz because the isolated aegelin from E. marmelos leaves contains of its enantiomer. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to aegelin stereochem nmr maja leaf aegle marmelos, Plant Biochemistry: Composition and Products and other aspects.Category: amides-buliding-blocks

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics