Category: 456-12-2

Mulualem, Yared Fikadu; Chandravanshi, Bhagwan Singh published an article in 2021, the title of the article was Assessment of metals content of widely used traditional toothbrushes in Addis Ababa, Ethiopia.Computed Properties of 456-12-2 And the article contains the following content:

Traditional toothbrushes are used by the vast majority of people who cannot afford to buy the com. toothbrush and toothpaste. The traditional toothbrushes are generally obtained from any slim woody part of a toothbrush tree. The main purpose of this study was to determine selected metals (Ca, Fe, Mg, Al, Cu, Cr, Ni, Zn, Mn, Pb, and Cd) in traditional toothbrushes obtained from three plants including Ligustrum vulgare L., Phoenix reclinata and Olea africana, which are extensively used in Addis Ababa, Ethiopia, by using microwave plasma-at. emission spectroscopy (MP-AES) after wet digestion. Recoveries of the metals in spiked samples varied from 90.4-107%. The overall mean concentrations determined (mg/kg, dry weight) were in the ranges of Ca (4267-36514) > Fe (131-318) > Al (81.6-224) > Mg (45.6-122) > Zn (27.2-175) > Mn (20.1-29) > Cu (6.6- 20.3) > Cr (6.7-8.9) > Ni (2.6-7.9). Anal. of variance at 95% indicated significant differences in the metals’ contents of three toothbrushes. The results indicated that the selected traditional toothbrushes are good sources of essential metals and free from Pb and Cd. Therefore, the investigated Ethiopian traditional toothbrushes are found to be safe for human use. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

The Article related to ligustrum vulgare phoenix reclinata olea africana metal toothbrush ethiopia, Mammalian Pathological Biochemistry: Other and other aspects.Computed Properties of 456-12-2

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On December 15, 2019, Sahu, Satya Narayan; Pattanayak, Subrat Kumar published an article.Product Details of 456-12-2 The title of the article was Molecular docking and molecular dynamics simulation studies on PLCE1 encoded protein. And the article contained the following:

Phospholipase C epsilon gene (PLCE1) is encoded the 1-phosphatidylinositol 4,5- bisphosphate phosphodiesterase 蔚-1 protein. This protein is characterized by the fetal onset of enormous proteinuria following by severe steroid resistance nephrotic syndrome (SRNS). The mutation position is located on the PIPLC_X domain of PLCE1 encoded protein. Mol. docking study was carried out between aegeline, berberine, diterpenoid, roseoside phytochems. with wild type and mutant of the PIPLC_X domain of the PLCE1 gene encoded protein. From the mol. docking study, it was found that, due to mutation the binding energy was decreased for aegeline, berberine diterpenoid and roseoside with mutant PLCE1 at S1484L compared to wildtype. To achieve the depth anal., we extended our study by performing the mol. dynamic simulation of 100 ns on wild type and the mutant (S1484L) model of above said domain of the studied protein. In the MD simulation study, we analyzed the result obtained from root mean square deviation, root mean square fluctuation, radius of gyration, solvation accessible surface area, hydrogen bond number and principal component anal. These dynamical behavior results of wild type protein show similar behavior with mutant protein. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Product Details of 456-12-2

The Article related to mol docking dynamic simulation plce1 phospholipase c epsilon, Enzymes: Structure-Conformation-Active Site and other aspects.Product Details of 456-12-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ray, Avishikta; Mishra, Rakhi; Singh, Anju; Biswal, Pramod K.; Yadav, Reenu; Ghatuary, Shailesh Kumar published an article in 2020, the title of the article was Phytochemistry, pharmacology and ethnomedicinal properties of Aegle marmelos.Electric Literature of 456-12-2 And the article contains the following content:

A review. Aegle marmelos is widely used by the traditional healers for treatments of various diseases like diarrhea, dysentery, diabetes, ulcer, inflammation etc. The variety of secondary metabolites are present in this plant which impart its medicinal uses. Further number of active constiuetns has been isolated from the Aegle marmelos. Present review focused on traditional uses, phytochem., pharmacol. and toxicol. of Aegle marmelos to support potential scope for advance ethnopharmacol. study. The extract of Aegle marmelos is reported to have numerous significant pharmacol. activities like antihyperglycemic, anti-inflammatory, antipyretic, analgesic, anticonvulsant, antihistaminic, anxiolytic, antidepressant, antioxidant, hepatoprotective, antimicrobial, analgesic, antifungal, neuroprotective etc evaluated by using various animal models. The present study summaries selected scientific evidence on phytochem., pharmacol. properties and ethnomedicinal uses of Aegle marmelos. The data was gathered via the Internet (using Scopus, PubMed, Google Scholar, Elsevier, Springer, Science Direct, Researchgate and Web of Science) as well as from libraries and local books. The aim of the current review article is to compile all the relevant published information regarding traditional uses, phytochem. and therapeutic potential of Aegle marmelos. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Electric Literature of 456-12-2

The Article related to review aegle leaf phytochem pharmacol ethnomedicinal property, Placeholder for records without volume info and other aspects.Electric Literature of 456-12-2

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Yuguda, Yakubu Magaji; Pandey, Rishikesh; Chavhan, Mayur Meghashyam; Mitra, Disha; Vijay, Aswathy; Ahmad, Sajjad; Daya, Minerva L.; Kumar, Shivam published an article in 2022, the title of the article was In-silico analysis for the confirmation of insulin receptor as a target for reported GLUT4 anti-diabetic natural compounds.HPLC of Formula: 456-12-2 And the article contains the following content:

There are 425 million people with diabetes in the World. There will be 629 million people with diabetes in the World in 2045. The insulin receptor controls glucose homeostasis, a physiol. mechanism that can lead to diabetes and cancer if disrupted. This study aimed to confirm the Insulin Receptor target for reported GLUT4 anti-diabetic natural compounds based on their pharmacokinetic properties, toxicity prediction, mol. docking, target anal., similar FDA approved drugs prediction, and mol. dynamic simulation. We selected 24 compounds on the basis of their mode of action from the anti-diabetic natural compounds database (ADNCD). Initially, we performed ADME anal. for the selected 24 compounds Among these 24 compounds, it has been found that 18 compounds followed the Lipinski Rule of Five. Further, we did a toxicity anal. of those 18 compounds, and it was found that 15 compounds were toxic in nature. We performed mol. docking against the Insulin Receptor (PDB ID: 1IR3) of the rest of the 3 compounds after ADME and toxicity anal. To understand the dynamic motions of the ligand-protein complex, we perform a root mean square fluctuation anal. We also checked the similarity of Apigenin from the FDA-approved drugs, but no similar mol. was found. It has been found that Apigenin was selected as the best compound as it showed the lowest binding energy and satisfied all our study parameters. Our promising findings based on preliminary and in-silico anal. need to be validated further by in-vitro and in-vivo studies. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2

The Article related to insulin receptor glut antidiabetic natural compound silico analysis, Placeholder for records without volume info and other aspects.HPLC of Formula: 456-12-2

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Amide – an overview | ScienceDirect Topics

On June 30, 2019, Gupta, Ena; Shakyawar, Snehlata; Sundaram, Shanthy published an article.Related Products of 456-12-2 The title of the article was Therapeutic and Nutraceutical Potential of Bioactive Compounds in Aegle marmelos (L.): An Overview. And the article contained the following:

A review. Aegle Marmelos (L.) Correa (A. marmelos), is a medicinal plant of Rutaceae family having a long history of curative property in traditional medicine. This plant is a rich source of bioactive compounds and natural antioxidants which can be isolated from its various parts such as fruit (carotenoids, tannins, flavonoids, ascorbic acid, marmelosin, marmelide, psoralen, aurapten, luvangetin); leaf (phenols, lupeol, skimmianine, citral, aegeline, eugenol, citronella, marmesinine) and bark (marmin, skimmianine, fagarine), etc. Many clin. and pre-clin. researches suggest the therapeutic applications of A. marmelos, such as anti-bacterial, anti-fungal, anti-viral, anti-ulcer, anti-diabetic, anticancer, anti-inflammatory and antioxidant properties which play a potential role in the prevention and treatment of various diseases. This review article focuses on exploring novel bioactive compounds of the above plant possessing potential therapeutic and health promoting applications. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to review aegle marmelos therapeutic nutraceutical potential bioactive compound, Placeholder for records without volume info and other aspects.Related Products of 456-12-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2021, Zhou, Luli; Wang, Dingfa; Zhou, Hanlin published an article.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Metabolic profiling of two medicinal Piper species. And the article contained the following:

Piper sarmentosum Roxb. (PS) and Piper cathayanum M. G. Gilbert & N. H. Xia (PC) are both listed as Traditional Chinese Medicine herbs. In this study, ultra-performance liquid chromatog. mass spectrometry (UPLC-MS/MS) was used to analyze secondary metabolites and metabolically profile the leaves, stems and roots in PS and PC. A total of 110 and 92 differential metabolites were shared from various organs of PS and PC, resp. Compared to the stems and roots of PS or PC, alkaloids and phenols in leaves of PS or PC accounted for 70% and 57% of the total alkaloids and phenols, resp. An anal. of enriched metabolic pathways demonstrated that L-tyrosine and 4-hydroxycinnamic acid in PS were directly involved in five and three metabolic pathways, which are related to the biosynthesis of isoquinoline alkaloids and phenol backbones, resp. The L-glutamic acid and oxoglutaric acid in PC were involved in seven and two metabolic pathways, resp. L-glutamic acid synthesizes heme, tropane, piperidine and pyridine alkaloids, and the type II polyketide backbone. Moreover, oxoglutaric acid generated via L-glutamic acid was mainly involved in the citrate cycle and played a fundamental role in determining these important metabolic processes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to piper tyrosine 4 hydroxycinnamic acid isoquinoline alkaloid tropane piperidine, Placeholder for records without volume info and other aspects.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

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Yuan, Ruiying; Dongzhi, Zhuoma; Guo, Wei; Zhen, Pu; Liu, Zhiming; Huang, Shan; Li, Bin; Yu, Jianqing published an article in , the title of the article was Hepatoprotective effect of Sophora moorcroftiana (Benth.) Benth.Ex baker seeds in vivo and in vitro.HPLC of Formula: 456-12-2 And the article contains the following content:

The leguminosae of Sophora moorcroftiana (Benth.) Benth.ex Baker is a drought-resistant endemic Sophora shrub species from the Qinghai-Tibet Plateau, and its seeds have hepatoprotective effects. To study the effect of S. moorcroftiana seeds on liver injury and the mol. mechanism underlying the beneficial effects, liquid chromatog.-mass spectrometry was used to detect the main active components in the ethanol extract of S. moorcroftiana seeds (SM). Male mice were divided into six groups (n = 8): normal control (NC), CCl4, SM (50, 100, 200 mg/kg), and di-Me di-Ph bicarboxylate (150 mg/kg) groups. Mice were treated as indicated (once/day, orally) for 14 days, and CCl4 (2 mL/kg) was administered i.p. The serum and liver of mice were used for biochem. assays. To explore the underlying mechanism, HepG2 cells were treated with SM, stimulated with tert-Bu hydroperoxide (t-BHP, 50 渭M), and analyzed by Western blotting. The major active compounds of SM were alkaloids including 22 compounds Serum alanine transaminase (ALT), aspartate transaminase (AST), and alk. phosphatase (ALP) decreased in the SM (200 mg/kg) group. SM can activate the expression of pregnane X receptor (PXR) and downstream mols. cytochrome P 4503A11 enzyme (CYP3A11), UDP glucuronosyltransferase 1 family polypeptide A 1 (UGT1A1), and inhibit the multidrug resistance protein 2 (MRP2). In addition, SM improved cell viability in t-BHP-induced HepG2 cells (64% to 83%) and decreased the activation of the mitogen-activated protein kinase (MAPK) pathway. The main compounds in SM were alkaloids. SM showed hepatoprotective effects possibly mediated by the suppression of oxidative stress through the MAPK pathway. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2

The Article related to sophora moorcroftiana baker seed hepatoprotective effect, hepg2, liver injury, mapk, pxr, oxidative stress, Placeholder for records without volume info and other aspects.HPLC of Formula: 456-12-2

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Banerjee, Sunil Kumar; Chakravarti, R. N. published an article in 1965, the title of the article was Action of Raney nickel on egeline, egelone, and dihydro egeline.Recommanded Product: 456-12-2 And the article contains the following content:

cf. CA 52, 13672h. Egeline, p-MeOC6H4CH(OH)CH2NHCOCH:CHPh, was refluxed about 10 hrs. with Raney Ni in a p-cymene solution, filtered hot, and cooled to give needle crystals (I). I was dissolved in EtOH and chromatographed on Brockmann alumina to yield dihydroegelone, m. 126-7° (EtOH), identified by its semicarbazone, m. 139-40°. Following the same procedure, egelone and dihydroegeline were both converted into dihydroegelone. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Recommanded Product: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dahlbom, Richard; Misiorny, Alfons published an article in 1957, the title of the article was Amines related to adrenaline containing nuclear chlorine.Formula: C18H19NO3 And the article contains the following content:

Nuclear substituted amino ketones were prepared from appropriate ω-chloroacetophenones and the desired amines. E.g., the appropriate ω-chloroacetophenone (0.025 mole) and the amine (0.065 mole) were dissolved in toluene (usually 25 ml.) and the mixture kept overnight at room temperature The amine hydrochloride was removed by filtration and the toluene solution washed with water and extracted with 2N HCl. The extract was made alkaline with aqueous Na2CO3 and the precipitated base extracted with Et2O. The extract was dried over Na2SO4 and the amino ketone was then isolated as the hydrochloride by the addition of ethereal HCl and recrystallized These compounds were of the general formula 3,4-R’RC6H3COCH2R”.HCl with R, R’, R”, and m.p. given: Cl, H, piperidino (I), 222-3° (free amine, m. 52-3°); OH, Cl, I, 268-270°; Cl, Cl, I, 249-51°; Cl, H, NHEt, 246-8°; Cl, H, 4-methyl-1-piperazinyl (II), 248-9°; Cl, Cl, II, 252-4°; Cl, H, 4-ethyl-1-piperazinyl, 266-8°; Cl, H, 4-carbethoxy-1-piperazinyl (III), 196-7°; Cl, Cl, III, 212-14° (free amine, m. 108-9°). Most of these amine hydrochlorides m. with decomposition and the yields were 41-87%. The hydrochlorides were converted to the free amino ketones which were dissolved in Et2O and reduced with LiAlH4 to give the following corresponding amino alcohols with R, R’, R”, and m.p. given in that order; Cl, H, I, 68.5-70°; Cl, Cl, I, 89-90°; Cl, H, NHEt, b0.8 190°, m. 87-8°; Cl, H, II, 85-85.5° (hydrochloride, m. 236-7°); Cl, Cl, II, 121-2°. A weak antagonism toward adrenaline and noradrenaline was shown by several of the piperidino compounds in experiments on the blood pressure of cats. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Formula: C18H19NO3

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Formula: C18H19NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chakravarti, R. N.; Dasgupta, B. published an article in 1956, the title of the article was Synthesis of aegelin.Application of 456-12-2 And the article contains the following content:

Anisaldehyde was converted to the corresponding cyanohydrin which was oxidized and with catalytic hydrogenation yielded β-hydroxy-β-p-methoxyphenylethylamine, which with cinnamoylation yielded aegelin. Dihydroaegelin, aegelone, and dihydroaegelone were synthesized in a similar manner. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application of 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Application of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics