Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 433-14-7, name is 4-Fluoro-N-methylbenzenesulfonamide, A new synthetic method of this compound is introduced below., name: 4-Fluoro-N-methylbenzenesulfonamide
A mixture of 4-fluoro-N-methyl-benzenesulfonamide (0.50 g, 2.64 mmoi), 1,4-dioxa-8-azaspiro[4.5]decane (0.76 g, 5.28 rnmoi) and potassium carbonate (0.73 g, 5.28 mrnoi) in amixed solvent of acetonitrile (10 mL) and 1 ,3-dimethythexahydropyrimidin-2-one (20 mL) was heated with stirring at 65 C for 3 hrs, The resulting reaction mixture was cooled to rt, dilutedwith water (50 mL) and extracted with EA (30 mL) for three times. The combined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo to give crude 4-(1 ,4-dioxa-8-azaspiro [4.5] decan-8-yl)-N-methyl-benzenesulfonamide (0.60 g), which was used in the next step without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Min; YANG, Song; (208 pag.)WO2016/107832; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics