A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4316-74-9, Name is Sodium 2-(methylamino)ethanesulfonate, molecular formula is C3H8NNaO3S. In an article, author is Wang, Yun,once mentioned of 4316-74-9, Safety of Sodium 2-(methylamino)ethanesulfonate.
In the search for improvement in the properties of gadolinium-based contrast agents, cyclodextrins (CDs) are interesting hydrophilic scaffolds with high molecular weight. The impact of the hydrophilicity of these systems on the MRI efficacy has been studied using five beta-CDs substituted with DOTA or TTHA ligands which, respectively, allow for one (q = 1) or no water molecule (q = 0) in the inner coordination sphere of the Gd3+ ion. Original synthetic pathways were developed to immobilize the ligands at C-6 position of various hydroxylated and permethylated beta-CDs via an amide bond. To describe the influence of alcohol and ether oxide functions of the CD macrocycle on the relaxation properties of the Gd3+ complexes, H-1 Nuclear Magnetic Relaxation Dispersion (NMRD) profiles, and O-17 transverse relaxation rates have been measured at various temperatures. The differences observed between the hydroxylated and permethylated beta-CDs bearing non-hydrated GdTTHA complexes can be rationalized by a second sphere contribution to the relaxivity in the case of the hydroxylated derivatives, induced by hydrogen-bound water molecules around the hydroxyl groups. In contrast, for the DOTA analogs the exchange rate of the water molecule directly coordinated to the Gd3+ is clearly influenced by the number of hydroxyl groups present on the CD, which in turn influences the relaxivity and gives rise to a very complex behavior of these hydrophilic systems.
Interested yet? Keep reading other articles of 4316-74-9, you can contact me at any time and look forward to more communication. Safety of Sodium 2-(methylamino)ethanesulfonate.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics