Application of 41921-63-5,Some common heterocyclic compound, 41921-63-5, name is 4,5-Dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one, molecular formula is C9H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
d) 7-Bromo-1 ,3,4,5-tetrahydro-2H-1 ,3-benzodiazepin-2-one.To a solution of 1 ,3,4,5-tetrahydro-2H-1 ,3-benzodiazepin-2-one (55 mg, 0.340 mmol) in dry dimethylformamide (3 mL) was added N-bromosuccinimide (67 mg, 0.374 mmol) in one portion. After 30 min, the reaction mixture was quenched with water (5 mL) and extracted with three 10 mL portions of ethyl acetate. The combined extracts were dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography (7% methanol in dichloromethane) to give 55 mg (67%,) of 7-bromo-1 ,3,4,5-tetrahydro-2H-1 ,3- EPO
The synthetic route of 41921-63-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/113432; (2006); A2;,
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