Category: 41337-83-1

Katsura, Yousuke et al. published their research in Journal of Medicinal Chemistry in 1994 | CAS: 41337-83-1

6-(Hydroxymethyl)picolinamide (cas: 41337-83-1) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 6-(Hydroxymethyl)picolinamide

Studies on antiulcer drugs. 7. 2-Guanidino-4-pyridylthiazoles as histamine H2-receptor antagonists with potent gastroprotective effects against nonsteroidal antiinflammatory drug-induced injury was written by Katsura, Yousuke;Inoue, Yoshikazu;Tomishi, Tetsuo;Ishikawa, Hirohumi;Takasugi, Hisashi. And the article was included in Journal of Medicinal Chemistry in 1994.Recommanded Product: 6-(Hydroxymethyl)picolinamide The following contents are mentioned in the article:

A series of 2-guanidino-4-pyridylthiazole derivatives were synthesized and evaluated for anti-aspirin-ulcer, gastric antisecretory, and histamine-H2-receptor-antagonist activities. Several compounds showed superior anti-aspirin-ulcer activity to that of clin. used H2-antagonists in the rat. Among them, 4-[6-(acetamidomethyl)pyridin-2-yl]-2-guanidinothiazole (I) demonstrated potent inhibitory activities against gastric lesions caused by 2 kinds of nonsteroidal antiinflammatory drugs, aspirin and indomethacin, resp., in addition to strong antisecretory activity. I possessed a preventable ability for the aspirin-induced reduction of the gastric mucosal blood flow at an intragastric administration of 32 mg/kg in the rat. Famotidine (32 mg/kg) exhibited no significant effect and ranitidine (100 mg/kg) aggravated the blood flow in this system. This study involved multiple reactions and reactants, such as 6-(Hydroxymethyl)picolinamide (cas: 41337-83-1Recommanded Product: 6-(Hydroxymethyl)picolinamide).

6-(Hydroxymethyl)picolinamide (cas: 41337-83-1) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 6-(Hydroxymethyl)picolinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics