Category: 4093-29-2

These common heterocyclic compound, 4093-29-2, name is Methyl 4-acetamido-2-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 4-acetamido-2-methoxybenzoate

At room temperature,Compound 64A (2.2 g, 10.0 mmol)Suspended in three volts of acetic anhydride, stirred until fully cooled to -10 C,Concentrated nitric acid (4 mL, 50 mmol) was slowly added dropwise at this temperature.After the dropwise addition, the temperature was raised to room temperature, and stirring was continued for 3 hours, and then the reaction liquid was poured into ice water.Extract with ethyl acetate (100 mL ¡Á 3), combine the organic phases, and dry.Concentration under reduced pressure gave compound 64B (2.8 g, 67%).

The synthetic route of Methyl 4-acetamido-2-methoxybenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Cao Wenjie; Zhang Guiping; Zhao Zhongqiang; Jiang Zhaojian; Zuo Gaolei; Xu Wanmei; Gong Hongju; Zhang Peng; Wang Jianghuai; Li Qingsong; Gao Chunhua; (79 pag.)CN104045552; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

4093-29-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4093-29-2, name is Methyl 4-acetamido-2-methoxybenzoate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To methyl 4-acetamido-2-methoxybenzoate (299 mg, 1.34 mmol) in acetic anhydride (3 ml) stirred under nitrogen at -10 C was added concentrated nitric acid (0.35 ml) dropwise. After then stirring at 0 C for 10 min the reaction mixture was partitioned between ethyl acetate (20 ml) and water (20 ml). The aqueous layer was further extracted with ethyl acetate (2 x 10 ml) and the combined organic extract washed with saturated sodium bicarbonate solution (2 x 10 ml), brine (2 x 10 ml), dried (MgSO_ and evaporated to give methyl 4-acetamido-2-methoxy-5 -nitrobenzoate (301 mg, 84%) as a dull orange powder. nmr (400 MHz, CDC13) delta 2.33, s, 3H, AcNH; 3.91, s, 3H, 2-MeO or COOMe; 4.03, s, 3H, COOMe or 2-MeO; 8.63, s, IH, H3 or H6; 8.84, s, IH, H6 or H3; 10.89, br, NH.

The synthetic route of Methyl 4-acetamido-2-methoxybenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PETER MACCALLUM CANCER INSTITUTE; MARTIN, Roger, Francis; WHITE, Jonathan; LOBACHEVSKY, Pavel; WINKLER, David; SKENE, Colin; MARCUCCIO, Sebastian; WO2011/123890; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

4093-29-2, A common heterocyclic compound, 4093-29-2, name is Methyl 4-acetamido-2-methoxybenzoate, molecular formula is C11H13NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 3-neck flask equipped with a mechanical stirrer was charged 250 g (1.12 mol) of 2-methoxy-4-acetylaminobenzoic acid methyl ester followed by 1L of methanol. Agitation was started and 94 mL (3.36 mmol, 3 eq. ) of concentrated sulfuric acid was slowly added creating a slight reflux. The mixture was stirred for 24 hr. The mixture was concentrated in vacuo affording a thick slurry. The slurry was filtered using a Buchner funnel and washed with 300 mL of cold methanol. The filter cake was collected and dried in vacuo at 45 C for 24 hr affording 302 g of 1a as a hemi-sulfate salt in a 96% yield.

The synthetic route of Methyl 4-acetamido-2-methoxybenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; WO2005/63755; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding some certain compound to certain chemical reactions, such as: 4093-29-2, name is Methyl 4-acetamido-2-methoxybenzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4093-29-2. 4093-29-2

[0543] To a solution of 269-3 (4.46 g, 20 mmol), PdOAc (0.45 g, 2 mmol) and Cu(OAe)2 (7.26 g, 40 mmol) in 1.2-dichloroethane ( 150 mL) was added anhydrous CuBr2 (8.93 g. 40 mmol) under N2 atmosphere. The mixture was stirred at 90 C for 72 h. After cooling to r.t., the reaction was quenched by water, and filtered through a celite pad. The solution was washed with brine, dried by anhydrous Na2S04 and concentrated at low pressure. The residue was purified by flash column chromatography on silica gel (PE:EA 1 : 1 ) to give 269-4 (6.04 g, 51 .3%). +ESI-MS:m/z 303.7 [M+I I]

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Methyl 4-acetamido-2-methoxybenzoate.

Reference:
Patent; ALIOS BIOPHARMA, INC.; WANG, Guangyi; BEIGELMAN, Leonid; TRUONG, Anh; NAPOLITANO, Carmela; ANDREOTTI, Daniele; HE, Haiying; STEIN, Karin, Ann; WO2015/26792; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics