Category: 39945-54-5

Reference of 39945-54-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39945-54-5, name is Benzyl (3-bromopropyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 7 3-[4-(2-Methoxyphenyl)piperazin-1-yl]propylamine The following is the preparation of a compound of Formula 3 in which R1 is methoxy, R2 is hydro and R9 is amino. A mixture of benzyl (3-bromopropyl)aminoformate (495.2 g, 1.82 mol), prepared as in Example 6, 1-(2-methoxyphenyl)piperazine hydrochloride (377.9 g, 1.65 mol) and potassium carbonate (456.8 g, 3.31 mol) in 3L of DMF was stirred at 80 to 81 C. for 3.5 hours. The mixture was allowed to cool to room temperature and then poured into 20L of water. The mixture was extracted with ethyl acetate (3*4L). The combined ethyl acetate extracts were washed with water (2*1L) and saturated aqueous sodium chloride (1*1L), dried (Na2 SO4) and treated with silica gel (200 g). The ethyl acetate was filtered and 11L of the filtrate was added slowly to 200 mL of 5.5N hydrochloric acid (2.75 mol) in ethanol at a rate such that the reaction temperature did not exceed 23 C. The mixture was aged at room temperature for 1 hour and filtered. The filtered residue was washed with ethyl acetate (3*500 mL), dried under a stream of air for 17 hours and then dried under reduced pressure at 60 C. to give benzyl 3-[4-(2-methoxyphenyl)piperazin-1-yl]propylaminoformate dihydrochloride (496 g, 1.09 mol), m.p. 174-176 C.

The synthetic route of Benzyl (3-bromopropyl)carbamate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Syntex (U.S.A.) Inc.; US5688795; (1997); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39945-54-5, name is Benzyl (3-bromopropyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C11H14BrNO2

Step B N-Benzyloxycarbonyl-N-methyl-3-bromopropylamine N-Benzyloxycarbonyl-3-bromopropylamine (from Step A; 1.0 g, 3.68 mM) was dissolved in dry THF (4 mL) and methyl iodide (522 mg, 3.68 mM) was added. After cooling to 0 C., potassium t-butoxide (3.68 mL of a 1M solution in THF) was added dropwise to the reaction mixture. The crude reaction mixture was filtered over a pad of Celite and washed through with ether. The combined filtrate and washings were concentrated under reduced pressure. The residue was flash chromatographed over 125 mL silica gel, eluding with 8:1 hexane-EtOAc, to give 890 mg pale yellow liquid, homogeneous on TLC in 80:20 hexane-EtOAc; 1 H-NMR (300 MHz, CDCl3, ppm) delta2.06 (m, 2H), 2.94 (s, 3H), 3.38 (m, 4H), 5.11 (s, 2H), 7.34 (m, 5H). Mass spectrum (FAB) m/e 288 (M+1)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 39945-54-5.

Reference:
Patent; Merck & Co., Inc.; US5411980; (1995); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics