Some common heterocyclic compound, 3972-65-4, name is 1-Bromo-4-(tert-butyl)benzene, molecular formula is C10H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 3972-65-4
Under nitrogen protection conditions,Dissolve 0.015 mmol of the nitrogen heterocyclic carbene precursor in 2 mL of anhydrous toluene.Add 0.01 mmol of palladium acetate and stir for 15 minutes.Add 0.6 mmol of sodium bis(trimethylsilyl)amide and stir for 20 minutes.0.4 mmol of compound A-1, 0.2 mmol of 4-tert-butylbromobenzene was added to the reaction solution.The reaction was carried out at 60 C for 12 hours. After the reaction is completed, Add 5 drops of water to extract the reaction, and take a suction filter funnel into the diatomaceous earth.After suction filtration, the mixture was washed three times with ethyl acetate.Column chromatography (petroleum ether: ethyl acetate = 3:1) gave product A-2.Yield: 95%;
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3972-65-4, its application will become more common.
Reference:
Patent; Zhejiang University City College; Li Jie; Yang Fan; Zhou Bihui; He Weiping; (24 pag.)CN108456172; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary