Synthetic Route of 3823-19-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3823-19-6, name is 2-Bromo-N-(4-(trifluoromethyl)phenyl)acetamide, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Potassium tert-butoxide (65.2 mg, 0.581 mmol, 1.05 eq) wasadded to a solution of thiols 10a~ b (0.554 mmol, 1.00 eq) in 5mLanhydrous N,N-dimethylformamide. The mixture was stirred atroom temperature before the a-bromoacetamide (0.554 mmol,1.00eq) was added, then the mixture was stirred for another 2 h. Toafford desired thioethers 11a~ e and 11h ~ l, the resulting mixturewas diluted with 50 mL ethyl acetate, washed with water(50 mL 3), dried with anhydrous sodium sulfate, and concentratedin vacuum. The residue was purified with a silica gel chromatographycolumn as white or pale yellow solid of 41e63% yield.
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-N-(4-(trifluoromethyl)phenyl)acetamide. I believe this compound will play a more active role in future production and life.
Reference:
Article; Han, Sheng; Sang, Yali; Wu, Yan; Tao, Yuan; Pannecouque, Christophe; De Clercq, Erik; Zhuang, Chunlin; Chen, Fen-Er; European Journal of Medicinal Chemistry; vol. 185; (2020);,
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