Category: 37394-93-7

Electric Literature of 37394-93-7, These common heterocyclic compound, 37394-93-7, name is 2-Chloro-N-(o-tolyl)acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Chrysin (1) (50 mg, 0.20 mmol), 2-chloro-N-(o-tolyl)acetamide (3) (38 mg, 0.21 mmol) andanhydrous potassium carbonate (56 mg, 0.41 mmol) were dissolved in DMF (2 mL). The reactionmixture was stirred at 80 C for 61 h, then, it was evaporated under reduced pressure. Water (30 mL)was added to the residue and it was extracted with DCM (30 mL). Then, saturated NaCl solution (20mL) was added to the aqueous phase and it was extracted with DCM (2 x 20 mL). The combinedorganic layer was dried over MgSO4 and concentrated in vacuo. The crude product was purified withpreparative TLC (DCM : MeOH = 40 : 1) to give 31 mg (46 %) of compound 13 as a yellow solid. M.p.:220-221 C. TLC (DCM : MeOH = 40 : 1); Rf = 0.69.

Statistics shows that 2-Chloro-N-(o-tolyl)acetamide is playing an increasingly important role. we look forward to future research findings about 37394-93-7.

Reference:
Article; Mayer, Szabolcs; Keglevich, Peter; Abranyi-Balogh, Peter; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba; Hazai, Laszlo; Molecules; vol. 25; 4; (2020);,
Amide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37394-93-7, name is 2-Chloro-N-(o-tolyl)acetamide, A new synthetic method of this compound is introduced below., name: 2-Chloro-N-(o-tolyl)acetamide

General procedure: General procedure.A mixture of 4 (4.59 g, 0.01 mol) and 2-chloro-N-substitutedacetamide derivatives (0.01 mol) in dry acetone (30 mL) andanhydrous K2CO3 (1.38 g, 0.01 mol) was stirred at room temperaturefor 8 h, filtered and the solid product formed was crystallizedfrom ethanol to give 5-18.

The synthetic route of 37394-93-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bua, Silvia; Ghorab, Mostafa M.; Soliman, Aiten M.; Supuran, Claudiu T.; European Journal of Medicinal Chemistry; vol. 200; (2020);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 37394-93-7 as follows. Quality Control of 2-Chloro-N-(o-tolyl)acetamide

General procedure: A mixture of 5a-j (18 mmol) and KI (4.4 g, 27 mmol) inacetone (40 mL) was refluxed for 2 h, and the solvent was evaporated in vacuo. Water was added, and the solids were collected and dried to give compounds 6a-j.

According to the analysis of related databases, 37394-93-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhu, Xiong; Fu, Junjie; Tang, Yan; Gao, Yuan; Zhang, Shijin; Guo, Qinglong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 4; (2016); p. 1360 – 1364;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 37394-93-7,Some common heterocyclic compound, 37394-93-7, name is 2-Chloro-N-(o-tolyl)acetamide, molecular formula is C9H10ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 2 (265mg, 1.0mmol), different 2-chloro-N-arylacetamide 4a-4q (1.0 mmol) and Et3N (1mL) in methanol (50 mL) was stirred at room temperature for 2 h. After thecompletion of the reaction, the solvent was removed under reduced pressure andthe residue was purified by silica gel column chromatography (EtOAc/petroleumether) to give the title compounds 5a-5q, respectively.

The synthetic route of 37394-93-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Guangcheng; Li, Xin; Wang, Jing; Xie, Zhenzhen; Li, Luyao; Chen, Ming; Chen, Shan; Peng, Yaping; Bioorganic and Medicinal Chemistry Letters; vol. 27; 5; (2017); p. 1115 – 1118;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics