Category: 372136-76-0

Wang, Bin published the artcileNew and convergent synthesis of saflufenacil, Safety of N-Methyl-N-isopropylsulfamoyl amide, the publication is Journal of Heterocyclic Chemistry (2020), 57(1), 151-156, database is CAplus.

A new practical and hundred-gram scale synthesis of saflufenacil, a protoporphyrinogen oxidase (PPO) inhibitor herbicide was described. The key intermediate N-methyl-N-iso-Pr sulfamide was obtained from sulfuryl chloride isocyanate, t-butanol and N-methyl-N-isopropylamine in 74.8% yield over 3 steps. Saflufenacil was prepared in 48.6% yield over 8 steps and 98.7% purity (HPLC).

Journal of Heterocyclic Chemistry published new progress about 372136-76-0. 372136-76-0 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Amine,Aliphatic hydrocarbon chain, name is N-Methyl-N-isopropylsulfamoyl amide, and the molecular formula is C4H6O3, Safety of N-Methyl-N-isopropylsulfamoyl amide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tang, A-ping published the artcileSynthesis of N-methyl-N-isopropyl sulfonamide, Application of N-Methyl-N-isopropylsulfamoyl amide, the publication is Nongyao (2013), 52(10), 721-722, 725, database is CAplus.

This article aims to explore and optimize a reasonable synthesis route of N-methyl-N-iso-Pr sulfonamide on industrial scale. Amino sulfonyl chloride was synthesized from chlorosulfonyl isocyanate and aqueous formic acid, then reacted with N-methy-N-iso-Pr amine to get the target product. The total yield was 62.7%. The products and intermediates were determined by ¹H NMR and MS and so on. The yield is improved and the process is simplified, which can be used in industry.

Nongyao published new progress about 372136-76-0. 372136-76-0 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Amine,Aliphatic hydrocarbon chain, name is N-Methyl-N-isopropylsulfamoyl amide, and the molecular formula is C9H8BNO2, Application of N-Methyl-N-isopropylsulfamoyl amide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wang, Da-Wei published the artcileDiscovery of Novel N-Isoxazolinylphenyltriazinones as Promising Protoporphyrinogen IX Oxidase Inhibitors, SDS of cas: 372136-76-0, the publication is Journal of Agricultural and Food Chemistry (2019), 67(45), 12382-12392, database is CAplus and MEDLINE.

Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is a promising target for herbicide discovery. Search for new compounds with novel chemotypes is a key objective for agrochemists. Here, we describe the discovery and systematic SAR-based structure optimization of novel N-isoxazolinyl-phenyl-triazinones as PPO inhibitors. The in vivo herbicidal activity and in vitro Nicotiana tabacum PPO (NtPPO) inhibitory activity were explored in detail. A number of the new synthetic compounds displayed strong PPO inhibitory activity with Ki values in the nanomolar range. Some compounds exhibited excellent and broad-spectrum weeds control at the rate of 9.375-37.5 g ai/ha by postemergence application, and showed improved monocotyledonous weeds control compared to saflufenacil. Most promisingly, Et 3-(2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-thioxo-1,3,5-triazinan-1-yl)-4-fluorophenyl)-5-methyl-4,5-dihydroisoxazole-5-carboxylate (I), with a Ki value of 4.9 nM, displayed over 2- and 6-fold higher potency than saflufenacil (Ki = 10 nM) and trifludimoxazin (Ki = 31 nM), resp. Moreover, I showed excellent and broad-spectrum weeds control against 32 kinds of weeds at 37.5-75 g ai/ha. Rice exhibited relative tolerance to I at 150 g ai/ha by post-emergence application, indicated that I could be a potential herbicide candidate for weed control in paddy fields.

Journal of Agricultural and Food Chemistry published new progress about 372136-76-0. 372136-76-0 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Amine,Aliphatic hydrocarbon chain, name is N-Methyl-N-isopropylsulfamoyl amide, and the molecular formula is C22H32O2, SDS of cas: 372136-76-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Rui-Bo published the artcileDesign, Synthesis, and Molecular Mechanism Studies of N-Phenylisoxazoline-thiadiazolo[3,4-a]pyridazine Hybrids as Protoporphyrinogen IX Oxidase Inhibitors, Synthetic Route of 372136-76-0, the publication is Journal of Agricultural and Food Chemistry (2020), 68(47), 13672-13684, database is CAplus and MEDLINE.

Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is an important target for green agrochem. discovery. Herein, a novel N-phenylisoxazoline-thiadiazolo[3,4-a]pyridazine herbicidal active scaffold was designed by the scaffold hybridization strategy. Systematic structural optimization enabled the discovery of a series of derivatives with excellent weed control at 9.375-150 g ai/ha by the post-emergent application. Some derivatives exhibited improved Nicotiana tabacum PPO (NtPPO)-inhibitory activity than fluthiacet-Me. Of these, I, with K_i = 21.8 nM, displayed higher weed control than fluthiacet-Me at the rate of 12-75 g ai/ha, and selective to maize at 75 g ai/ha. In planta, I was converted into a bioactive metabolite II (K_i = 4.6 nM), which exhibited 4.6-fold more potency than I in inhibiting the activity of NtPPO. Mol. dynamics simulation explained that II formed stronger π-π interaction with Phe392 than that of I. This work not only provides a promising lead compound for weed control in maize fields but is also helpful to understand the mol. mechanism and basis of the designed hybrids.

Journal of Agricultural and Food Chemistry published new progress about 372136-76-0. 372136-76-0 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Amine,Aliphatic hydrocarbon chain, name is N-Methyl-N-isopropylsulfamoyl amide, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 372136-76-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lange, Jos H. M. published the artcileNovel 3,4-diarylpyrazolines as potent cannabinoid CB₁ receptor antagonists with lower lipophilicity, Recommanded Product: N-Methyl-N-isopropylsulfamoyl amide, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(21), 4794-4798, database is CAplus and MEDLINE.

3,4-Diarylpyrazolines as potent CB₁ receptor antagonists with lipophilicity lower than that of SLV319 are described. The key change was the replacement of the arylsulfonyl group in the original series by a dialkylaminosulfonyl moiety. The absolute configuration (4S) of enantiomer I was established by X-ray diffraction anal. and I showed a close mol. fit with rimonabant in a CB₁ receptor-based model. II exhibited the highest CB₁ receptor affinity (K_i = 24 nM) in this series, as well as very potent CB₁ antagonistic activity (pA ₂ = 8.8) and a high CB₁/CB₂ subtype selectivity (∼147-fold).

Bioorganic & Medicinal Chemistry Letters published new progress about 372136-76-0. 372136-76-0 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Amine,Aliphatic hydrocarbon chain, name is N-Methyl-N-isopropylsulfamoyl amide, and the molecular formula is C4H12N2O2S, Recommanded Product: N-Methyl-N-isopropylsulfamoyl amide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics