Category: 37073-15-7

Electric Literature of 37073-15-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37073-15-7 name is 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Et3N (0.22 g, 2.2 mmol) was added to a suspension of 2,2′-AzPy-dicarboxylic acid 2a-c (0.275 g, 1 mmol) in anhydrous DMF (4 mL) in a dried 10 mL heavy-walled Pyrex tube containing a long stir bar. BtSO2Me (0.43 g, 2.2 mmol) was added to this solution and exposed to microwave irradiation (30 W) for 15 min at 70 C with vigorous stirring and simultaneous air cooling. After completion of the reaction, the mixture was cooled to r.t. and poured onto crushed ice-water mixture (~20 g). The precipitate formed was filtered and washed with aq 10% Na2CO3 (3 × 5 mL), H2O, and Et2O. The solid was dried to yield 2,2′-AzPy-diacylbenzotriazoles 3a-c as microcrystals (Table 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole, and friends who are interested can also refer to it.

Reference:
Article; Avan, Ilker; Synthesis; vol. 48; 3; (2016); p. 365 – 378;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 37073-15-7, name is 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole, molecular formula is C7H7N3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H7N3O2S

Example 1 (E)-1-(benzotriazol-1-yl)-3-phenyl-2-propen-1-one 1.42 g (0.01 mol) of trans-cinnamic acid (compound of formula IV) and 1.97 g (0.01 mol) of 1-(methylsulfonyl)benzotriazole are stirred at room temperature in 50 ml of tetrahydrofuran, followed by dropwise addition of 0.014 mol of triethylamine. The solution is then refluxed for 24 hours, and then evaporated under reduced pressure. The residue is taken up in 60 ml of water and extracted with 70 ml of ethyl acetate. The organic phase is dried, filtered and then concentrated under vacuum. The powder obtained is taken up in 50 ml of acetonitrile and filtered off by suction. 2.24 g of a white powder are obtained. Melting point: 157 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 37073-15-7, its application will become more common.

Reference:
Patent; PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE; Rault, Sylvain; Lancelot, Jean Charles; Suzanne, Peggy; Voisin-Chiret, Anne-Sophie; Pecquet, Regis; Joseph, Jean-Christophe; US2013/165507; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 37073-15-7,Some common heterocyclic compound, 37073-15-7, name is 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole, molecular formula is C7H7N3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of alpha,beta-unsaturated aromatic or aliphatic acid (10 mmol), CH3SO2Bt (10 mmol) and Et3N (15 mmol) were refluxed in dry THF (50 mL) overnight. The solvent was evaporated and the residue was dissolved in CH2Cl2 (100 mL). The organic phase was washed with brine (3 times) and dried over anhydrous Na2SO4. The organic phase was concentrated under vacuum to give a crude product, which could be further purified by recrystallization from a proper solvent.

The synthetic route of 37073-15-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xia, Ziming; Lv, Xin; Wang, Wencun; Wang, Xiaoxia; Tetrahedron Letters; vol. 52; 38; (2011); p. 4906 – 4910;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 37073-15-7, The chemical industry reduces the impact on the environment during synthesis 37073-15-7, name is 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole, I believe this compound will play a more active role in future production and life.

A flame-dried, two necked, round bottomed flask was charged with methanesulfonyl benzotriazole (34b) (1.0 g, 0.005 mol), 2-furoic acid (0.57 g, 0.005 mol), dry triethylamine (2 ml_), and dry THF (20 ml_) under argon. The resulting solution was heated at reflux for 18 hours. After this time, the THF was removed under reduced pressure to afford a cream coloured residue, which was taken up in ethyl acetate and washed with 1 M HCI (3 chi 30 ml_). The ethyl acetate was dried (MgS04) and removed in vacuo to afford a white solid which was recrystallised from toluene to give the title compound (34c) as fluffy white crystals (0.82 g, 77.0 %); mp 171 – 172 C; Rf = 0.48 (DCM : petroleum ether, 5 : 5); Analysis Calcd. for Cn H7N302: C, 61.97; H, 3.31 ; N, 19.71 %. Found C, 61.73; H, 3.31 ; N, 19.71 %; vmax (KBr) / cm”1 3142 (NH), 1681 (C=0), 1556, 1447; deltaEta (d6-DMSO, 300 MHz) 8.30 (3H, m, H5, H8, H5), 8.08 (1 H, dd, 3. 4.= 3.8, Jy, v= 0.6, H3), 7.82 (1 H, td, J6, 5/ 7= 7.2, 6, 8= 1.2, H6), 7.65 (1 H, td, J7, 6/s=7.2, J7, 5= 1.2, H7), 6.94 (1 H, dd, 4. 3.= 3.8, 4. 5.= 1.8, H4); 5c(d6-DMSO, 75 MHz) 155.0 (CO), 150.8 (C5), 145.5 (C9), 144.4 (C2) 132.1 (C4), 131.3 (C6), 127.1 (C7), 125.4 (C3), 120.6 (C5 or C8), 114.7 (C5 or C8), 113.9 (C4).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITY OF SUNDERLAND; TODD, Adam; ANDERSON, Rosaleen Joy; SMALL, David Antony Philip; GROUNDWATER, Paul William; BENTON, Matthew Richard; WO2014/96864; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 37073-15-7, name is 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37073-15-7, category: amides-buliding-blocks

To a solution of 2-(4-fluorophenyl)acetonitrile (2 g, 15 mmol) in DMSO (15 mL) at 8 C was added t-BuOK (2.84 g, 29 mmol). The mixture was stirred for 10 min and a solution of compound 6-1 (2.92 g, 15 mmol) in DMSO (40 mL) was then added slowly via an addition funnel. The reaction mixture was warmed to RT and stirred overnight, quenched with water, and neutralized with saturated aq. NH4C1. The mixture was extracted with EtOAc (3×100 mL). The combined organic layers were washed with water, brine, dried over MgS04, and filtered. The filtrate was concentrated and purified by silica gel column chromatography (PE/EtOAc = 5: 1) to give 6-2.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CUMMING, Jared, N.; KAELIN, David Earl, Jr.; SCOTT, Jack, D.; WU, Wen-Lian; BURNETT, Duane, A.; WO2014/99794; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37073-15-7, name is 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole, A new synthetic method of this compound is introduced below., Product Details of 37073-15-7

General procedure: A mixture of alpha,beta-unsaturated aromatic or aliphatic acid (10 mmol), CH3SO2Bt (10 mmol) and Et3N (15 mmol) were refluxed in dry THF (50 mL) overnight. The solvent was evaporated and the residue was dissolved in CH2Cl2 (100 mL). The organic phase was washed with brine (3 times) and dried over anhydrous Na2SO4. The organic phase was concentrated under vacuum to give a crude product, which could be further purified by recrystallization from a proper solvent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Xia, Ziming; Lv, Xin; Wang, Wencun; Wang, Xiaoxia; Tetrahedron Letters; vol. 52; 38; (2011); p. 4906 – 4910;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37073-15-7, name is 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C7H7N3O2S

General procedure: A mixture of alpha,beta-unsaturated aromatic or aliphatic acid (10 mmol), CH3SO2Bt (10 mmol) and Et3N (15 mmol) were refluxed in dry THF (50 mL) overnight. The solvent was evaporated and the residue was dissolved in CH2Cl2 (100 mL). The organic phase was washed with brine (3 times) and dried over anhydrous Na2SO4. The organic phase was concentrated under vacuum to give a crude product, which could be further purified by recrystallization from a proper solvent.

The synthetic route of 37073-15-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xia, Ziming; Lv, Xin; Wang, Wencun; Wang, Xiaoxia; Tetrahedron Letters; vol. 52; 38; (2011); p. 4906 – 4910;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics