Category: 360-92-9

Bravo-Zhivotovskii, D. A. published the artcileReactions of triethylgermyllithium with N,N-dialkylamides of carboxylic acids, Product Details of C6H10F3NO, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1982), 949-51, database is CAplus.

Reaction of Et₃Geli with RCONR¹₂ (R = Ph, R¹ = Et; R = Me, Me₃C, R¹ = Me) gave RCOGeEt₃ (I) and products from the reaction of I with the formed Li derivatives

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bravo-Zhivotovskii, D. A. published the artcileReaction of triethylgermyllithium with N,N-dialkylamides of carboxylic acids, Application In Synthesis of 360-92-9, the publication is Zhurnal Obshchei Khimii (1983), 53(8), 1838-43, database is CAplus.

The title reaction gives the corresponding acylgermanes. The regioselectivity of the reaction depends on the nature of the acyl fragment, the solvent and temperature Thus, reaction of Et₃GeLi with BzNEt₂ in hexane at 20° gave 88% BzGeEt₃.

Zhurnal Obshchei Khimii published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application In Synthesis of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bravo-Zhivotovskii, D. A. published the artcileReactions of triethylgermyllithium with N,N-dialkylated carboxamides, Related Products of amides-buliding-blocks, the publication is Journal of Organometallic Chemistry (1983), 248(1), 51-60, database is CAplus.

AcNMe₂, Me₃CCONMe₂, F₃CCONEt₂ and BzNEt₂ reacted with Et₃GeLi, which is made from (Et₃Ge)₂Hg and Li in hexane, to give the corresponding acyltriethylgermanes as the principal product. The regioselectivity depends markedly on the reaction conditions and the nature of the acyl fragment of amides. Thus, Et₃GeLi reacted with AcNMe₂ as metalating agent to give LiCH₂CONMe₂ in THF. Mechanistic interpretations of these results are discussed.

Journal of Organometallic Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lunazzi, L. published the artcileConformational analysis in heteroaromatic carbonyl compounds. I. Radical anions of 2,5-thiophenedicarboxaldehyde and related derivatives, Category: amides-buliding-blocks, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1972), 751-4, database is CAplus.

The room temperature ESR spectrum of the photolytically generated radical anion of 2,5-thio-phenedicarboxaldehyde (I) showed the existence of 2 of the 3 possible rotational isomers. The less stable was the O-cis-trans isomer as seen from the nonequivalence of the thiophene proton splittings. Examination of several derivatives of I, e.g. thieno[3,2-b]-thiophene-2,5-dicarboxaldehyde, with different steric requirements allowed the assignment of the O-cis-cis conformation to the other rotamer.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zaitseva, N.A. published the artcileSynthesis of fluorinated ketones with organolithium compounds and N,N-dialkylamides of fluorinated acids, Product Details of C6H10F3NO, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1961), 831-5, database is CAplus.

cf. CA 53, 17933g. Adding 17.2 g. CHF₂CONEt₂ (I) in Et₂O to PhLi (0.1 mole PhBr) in Et₂O at -70° and stirring 2 hrs. gave after treatment with dilute HCl 83% CHF₂Bz, b_10-12 63-5°, n²⁰_D 1.4900. Similar reaction with crystalline PhLi in MePh gave a 67% yield, while the use of PhNa in MePh gave but 29% product. 2-Thienyllithium and I gave 75% 2-CHF₂-COC₄H₃S, b₁₁ 77-80°, b₁₃ 80°. Similarly, PhLi and CF₃CONEt₂ (II) gave 74% CF₃Bz, b³⁷ 66-8°, 1.4578, in Et₂O, while the yield was 54.5% in MePh. 2-Thienyllithium and II in Et₂O gave 39% 2-CF₃COC₄H₃S, b_23-4 67°. CF₃COCl and Et₂NH in Et₂O at 0° gave 47.4% II, b₄₃ 74-5°. PhLi in Et₂O and CHFClCONEt₂ gave 53% CHFClBz, b₁₁ 91°. Addition of 40.8 g. I to 0.36 mole BuLi in Et₂O over 2 hrs. at room temperature gave 32.6% CHF₂COBu, b. 111-12°.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C4Br2N2O4S, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Juntian published the artcileAtypical Mode of [3 + 2]-Cycloaddition: Pseudo-1,3-dipole Behavior in Reactions of Electron-Deficient Thioamides with Benzynes, Quality Control of 360-92-9, the publication is Organic Letters (2018), 20(18), 5550-5553, database is CAplus and MEDLINE.

Thioamides bearing electron-withdrawing groups on the thiocarbonyl carbon atom react with benzynes [generated by the hexadehydro-Diels-Alder cycloisomerization] in an unprecedented fashion. Namely, the dihydrobenzothiazole products are consistent with a pathway involving initial formation of a stabilized ammonium ylide by a rare type of [3 + 2]-cycloaddition reaction. The fate of this species depends upon the nature of the substituents attached to the ylide nitrogen atom. The demonstration of new modes of reactivity represents the major advance arising from this study.

Organic Letters published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C8H7NO4, Quality Control of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Coe, Paul L. published the artcileReactions of tetrafluoroethene oligomers. Part 15. Reactions of perfluoro-3,4-dimethylhex-3-en-2-one; a highly reactive α,β-unsaturated ketone, Computed Properties of 360-92-9, the publication is Perkin 1 (2000), 1529-1535, database is CAplus.

Perfluoro-3,4-dimethylhexenone I has been shown to react with nucleophiles both at the double bond and at the carbonyl group depending on the type of nucleophilic center and also on the steric requirements of the attacking reagent. In many cases the first formed product undergoes further reactions either with the original nucleophile or by intramol. processes. Thus, reaction of I with primary amines afforded azetines II (R = Et, c-C₆H₁₁, Me₃C); with Me₃CNH₂, a mixture of an azetine II (R = Me₃C) and a ketenimine III was formed. III either on standing at room temperature or more quickly on heating cyclized quant. to II (R = Me₃C). Reaction of the enone with secondary amines took a different course; the products from reaction with diethylamine were an unsaturated amide and N,N-diethyltrifluoroethanamide, and piperidine afforded not only an unsaturated amide and the corresponding ethanamide but also a piperidyl ketone IV. IV is postulated to be the archetype of the first formed product for all the reactions reported. Reaction with dimethylamine yielded a different product, a disubstituted unsaturated ketone, but none of the corresponding amides as seen with other secondary amines. The reaction with hydrazine afforded a substituted pyrazolidine V. When the enone was treated either with triethylamine or with fluoride ion cyclization to yield a perfluorotetramethyldihydrofuran VI occurred. Reaction with sodium methoxide or sodium phenoxide yielded bis-ether derivatives, while reaction with sodium hypochlorite gave a hydrogen containing epoxide, postulated to arise from a haloform type reaction from the first formed epoxide. Finally, reaction with methylmagnesium iodide gave a fluoroethylidene trifluoromethylhexanone derivative A mechanistic rationale based on a series of addition-elimination reactions with or without subsequent cyclization is proposed to explain these reactions.

Perkin 1 published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Computed Properties of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Suarez, Cristina published the artcileProton NMR studies of symmetrically-substituted N,N-dialkyltrifluoroacetamides: medium effects, Quality Control of 360-92-9, the publication is Journal of Physical Chemistry (1990), 94(17), 6679-83, database is CAplus.

Activation parameters characterizing the internal rotation about the C-N partial double bond in CF₃CONR₂ (R = Et, CHMe₂, CH₂CHMe₂) were determined from exchange-broadened ¹H NMR spectra. Gibbs energies of activation, ΔG₂₉₈ (kcal mol^-1), for the gaseous amides and their 1% CCl₄ solutions as follows: di-Et, 16.1/17.8; diisopropyl, 15.8/16.3; diisobutyl, 16.4/17.3. In both the gas and liquid phases the rotational barriers decrease with increasing N-alkyl substituent bulk. The phase dependence of these parameters is compatible with expected solvent internal pressure effects. Lower gas-phase activation energies are consistent with a process proceeding via a transition state with greater steric requirements than the ground-state configuration.

Journal of Physical Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H4ClNO2, Quality Control of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Leonov, O. N. published the artcileSynthesis and properties of N²-acylated polyfluoroalkanamidines, Formula: C6H10F3NO, the publication is Zhurnal Obshchei Khimii (1992), 62(7), 1592-7, database is CAplus.

Acylating HN:C(CF₃)NR₂ (I; R = Me, Et) with R¹COCl (R¹ = CF₃, CHF₂, C₂F₅) in Et₂O containing Et₃N gave 5 corresponding R¹CON:C(CF₃)NR₂ in 64.1-89.1% yield. Analogous reaction of CF₃COCl with HN:C(CF₃)NHMe (II) gave CF₃CON:C(CF₃)NHMe and CF₃CONHC(CF₃):NMe in 45.2% combined yield, and (CF₃)₂C:CO (III) and II gave 86.4% (CF₃)₂CHCON:C(CF₃)NHMe. I (same R) and HN:C(C₂F₅)NEt₂ added to III to give 64.1-93.4% (CF₃)₂CHCON:CR²NR₂ [R = Me, Et (IV), R² = CF₃; R = Et, R² = C₂F₅], and IV was hydrolyzed to (CF₃)₂CHCONH₂ and CF₃CONEt₂. IR and ¹H and ¹⁹F NMR data were given for all title products.

Zhurnal Obshchei Khimii published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Formula: C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lindenschmidt, Cathrin published the artcile8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties, Recommanded Product: N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is European Journal of Medicinal Chemistry (2016), 280-290, database is CAplus and MEDLINE.

A series of 8-chloronaphtho[2,3-b]thiophene-4,9-diones and also some 8-bromo analogs were prepared The compounds were evaluated for their potencies to suppress keratinocyte hyperproliferation using the human keratinocyte line HaCaT as the primary test system. Structure-activity relationship studies revealed that replacement of the phenolic group of an earlier series with an 8-halogen atom retained the inhibitory potency against keratinocyte hyperproliferation with IC₅₀ values in the submicromolar range. 8-Chloro-substitution led to inhibitors that were more potent than their bromo analogs. Concomitantly, halo-substitution eliminated membrane-damaging properties as assessed by LDH release from the cytoplasm of the keratinocytes which, in contrast, were induced by the corresponding phenolic analogs. Finally, selective compounds were characterized for their ability to participate in redox cycling to generate superoxide in enzymic and keratinocyte-based studies.

European Journal of Medicinal Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Recommanded Product: N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics