Category: 360-92-9

Ovchinnikova, N. S. published the artcileMass-spectroscopic study of fluoroalkylated and fluoroacylated alkylamines, ethylenediamines and propylenediamines, Product Details of C6H10F3NO, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1986), 827-32, database is CAplus.

The mass spectra of RCONEt₂ (R = CF₃, C₆F₁₃), R¹CONHCH₂CH₂NHCOR (R¹ = CF₃, C₈F₁₇), C₈F₁₇CONHCH₂CH₂NH₂, CF₃CONHCH₂CH(CF₃)NHCOCF₃, R²XNHCH₂CHMeNH₂ (R² = CF₃, C₃F₇, C₆F₁₃, C₈F₁₇; X = CO, CH₂), and R²XNH(CH₂)₃NMe₂ (same R², X) were analyzed. The structure of the amine affected the spectra more strongly than the size of the fluorinated radical.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Forbus, T. R. Jr. published the artcileReactions of the readily accessible electrophile, trifluoroacetyl triflate: a very reactive agent for trifluoroacetylations at oxygen, nitrogen, carbon, or halogen centers, Recommanded Product: N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Journal of Organic Chemistry (1987), 52(19), 4156-9, database is CAplus.

Trifluoroacetyl triflate (I) is readily prepared in 82% yield by the dehydration (P₂O₅) of a 2:1 mixture of CF₃CO₂H and CF₃SO₃H. Reactions of this highly electrophilic trifluoroacetylating reagent with alcs., ketones, ethers, amines, and pyridines give esters, enol esters, ether cleavage, amides, and acylpyridinium ions, resp. Reactions with ionic or easily ionizable alkyl halides give the very volatile trifluoroacetyl halides and the ionic triflate. Triphenylmethyl chloride, for example, is quant. converted to triphenylcarbenium triflate in a very convenient synthetic procedure. I is used in the synthesis of the first member of a new class of pyrylium salts, 2,6-dimethoxypyrylium triflate.

Journal of Organic Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Recommanded Product: N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Li, AnRong published the artcileA convenient trifluoroacetylation of amines with trifluoroacetic acid and titanium tetrachloride, Recommanded Product: N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Chinese Journal of Chemistry (1993), 11(2), 190-2, database is CAplus.

Treating R¹R²NH (R¹ = H, R² = Ph, cyclohexyl, allyl, Me₂CHCH₂, 2-NH₂C₆H₄, 2-HOC₆H₄; R¹ = R² = Et; R¹ = Ph, R² = Me) with CF₃CO₂H, 2 equiv Et₃N, and 2 equiv TiCl₄ in Et₂O, MeCN, or CH₂Cl₂ gave 40-75% R¹R²NCOCF₃ (same R¹, R²); in the case of o-phenylenediamine, the product is 2-(trifluoroacetyl)benzimidazole.

Chinese Journal of Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Recommanded Product: N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Husain, S. Shaukat published the artcilep-Trifluoromethyldiazirinyl-etomidate: A Potent Photoreactive General Anesthetic Derivative of Etomidate That Is Selective for Ligand-Gated Cationic Ion Channels, Synthetic Route of 360-92-9, the publication is Journal of Medicinal Chemistry (2010), 53(17), 6432-6444, database is CAplus and MEDLINE.

We synthesized the R- and S-enantiomers of Et 1-(1-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)ethyl)-1H-imidazole-5-carboxylate (trifluoromethyldiazirinyl-etomidate) (I), or TFD-etomidate, a novel photoactivable derivative of the stereoselective general anesthetic etomidate [R-(2-Et 1-(phenylethyl)-1H-imidazole-5-carboxylate)]. Anesthetic potency was similar to etomidate’s, but stereoselectivity was reversed and attenuated. Relative to etomidate, TFD-etomidate was a more potent inhibitor of the excitatory receptors, nAChR (nicotinic acetylcholine receptor) ((α1)₂β1δ1γ1) and 5-HT_3AR (serotonin type 3A receptor), causing significant inhibition at anesthetic concentrations S- but not R-TFD-etomidate enhanced currents elicited from inhibitory α1β2γ2L GABA_ARs by low concentrations of GABA, but with a lower efficacy than R-etomidate, and site-directed mutagenesis suggests they act at different sites. [³H]TFD-etomidate photolabeled the α-subunit of the nAChR in a manner allosterically regulated by agonists and noncompetitive inhibitors. TFD-etomidate’s novel pharmacol. is unlike that of etomidate derivatives with photoactivable groups in the ester position, which behave like etomidate, suggesting that it will further enhance our understanding of anesthetic mechanisms.

Journal of Medicinal Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Synthetic Route of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Fishwick, Colin W. G. published the artcileAn efficient route to S-N-(9-fluorenylmethyoxycarbonyl)-4′-(1-azi-2,2,2-trifluoroethyl)phenylalanine, Product Details of C6H10F3NO, the publication is Tetrahedron Letters (1994), 35(26), 4611-14, database is CAplus.

An extremely efficient synthesis of optically pure photoactivatable phenylalanine derivative I is described. The key step involves a highly diastereoselective alkylation of chiral glycine equivalent II with benzyl iodide III to give benzylated product IV.

Tetrahedron Letters published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jack, Thomas published the artcileSynthesis and characterization of photoaffinity probes that target the 5-HT₃ receptor, Application of N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Chimia (2014), 68(4), 239-242, database is CAplus and MEDLINE.

The 5-HT₃ receptor is one of several ion channels responsible for the transmission of nerve impulses in the peripheral and central nervous systems. Until now, it was difficult to characterize transmembrane receptors with classical structural biol. approaches like x-ray crystallog. The use of photoaffinity probes is an alternative approach to identify regions in the protein where small mols. bind. To this end, the authors present two photoaffinity probes based on granisetron, a well known antagonist of the 5-HT₃ receptor. These new probes show nanomolar binding affinity for the orthosteric binding site. In addition, the authors investigated their reactivity using irradiation experiments

Chimia published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application of N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rasu, Loorthuraja published the artcileA Fortuitous, Mild Catalytic Carbon-Carbon Bond Hydrogenolysis by a Phosphine-Free Catalyst, Application of N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Australian Journal of Chemistry (2016), 69(5), 561-564, database is CAplus.

The putative catalyst trans-[Ru((S,S)-skewphos)(H)₂((R,R)-dpen)] (skewphos=2,4-bis(diphenylphosphino)pentane; dpen=1,2-diphenylethylenediamine) transforms the trifluoroacetyl amide 2,2,2-trifluoro-1-(piperidin-1-yl)ethanone under mild conditions (4 atm H₂, room temperature, 4-24h, 1 mol-% Ru, 15 mol-% KOtBu in tetrahydrofuran) to generate the formylated amine 1-formylpiperidine and fluoroform via C-C bond hydrogenolysis. Catalysts are also prepared by reacting cis-[Ru(η³-C₃H₅)(MeCN)₂(COD)]BF₄ (COD=1,5-cyclooctadiene) with diamine ligands in situ. Low-temperature NMR studies provided insight into this reaction.

Australian Journal of Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application of N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Robson, John H. published the artcileThe infrared spectra of N-substituted trifluoroacetamides, COA of Formula: C6H10F3NO, the publication is Journal of the American Chemical Society (1955), 498-9, database is CAplus.

Et₂NH (14.6 g.) in 100 cc. Et₂O cooled to -10°, treated with 14 cc. (CF₃CO)₂O, and the mixture warmed to room temperature, washed with H₂O, dried, and fractionated gave 11.7 g. CF₃CONEt₂, b₂₄ 65-7°, n_D²⁴ 1.3782. Similarly were prepared the following CF₃CONHR (R, b.p./mm., m.p., and n_D²⁵ given): iso-Pr, 71-2°/20.5, 51.0-2.3° (from hexane), -; Bu, 100-1°/28.5, -, 1.3805; and the amides CF₃CONR₂: iso-Pr, -, 52-2.5°, -; Bu, 106°/16.0, -, 1.3997; iso-Bu, 89.0-9.5°/13.4, -, 1.4017. By conventional methods were prepared the following AcNR₂ (same data given): Et, 179-81°/700, (88.5-91.0°/31.0), -, 1.4333; Pr, 94.5°/12.0, -, 1.4411; Bu, 238°/705, (116.5°/8.0), -, 1.4451. (iso-Bu)₂NH (106 cc.) added to 240 cc. purified Ac₂O, the mixture heated to 110°, and 170 cc. AcOH and excess Ac₂O distilled off yielded 75.3 g. (iso-Bu₂)NAc, b_0.8 102.5-103.0, n_D²⁵ 1.4434; it was reported previously by Chute, et al. (C.A. 42, 4919b), to be a solid, m. 74°, which was probably (iso-Bu)₂NNO₂. HCONHEt₂, b_15.0 69°, n_D²⁵ 1.4296, was prepared by the method of Ott, et al. (C.A. 37, 5014.3). (Me₂CH)₂NH (101 g.) added below 60° to 46.0 g. 98-100% HCO₂H in 200 cc. m-xylene, the mixture refluxed 48 hrs. with the H₂O of reaction removed continuously, and the homogeneous solution fractionated gave 54.0 g. HCON(CHMe)₂, b_23.5 93-3.8°, m. 11.6°, n_D²⁵ 1.4371. Similarly were prepared HCONPr₂, b₇₁₅ 206-7°, n_D²⁵ 1.4384 (could not be crystallized at -70°), and HCONBu₂, b_7.8 101°, n_D²⁰ 1.4400. The infrared absorption maximum of the compounds described are tabulated.

Journal of the American Chemical Society published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, COA of Formula: C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dvorak, Thomas published the artcileSynthesis of substituted thieno[2,3-d]isothiazoles as potential plant activators, Quality Control of 360-92-9, the publication is ARKIVOC (Gainesville, FL, United States) (2013), 245-265, database is CAplus.

Thieno[2,3-d]isothiazoles were synthesized as potential plant activators. Based on previously reported thienothiadiazole plant activators, one ring nitrogen was eliminated from the bicyclic motif in order to extend structure activity relationship information. Thieno[2,3-d]isothiazoles bearing different functional groups, e.g., I (R = Me, Ph, H, CF₃), were prepared starting from readily available 3,4-dibromothiophene. Introduction of an oxime and a methylthio group in positions 1 and 2 of the thiophene system set the stage for cyclization, which occurred spontaneously after converting the oxime into the more reactive oxime ester in the presence of methanesulfonyl chloride.

ARKIVOC (Gainesville, FL, United States) published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Quality Control of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sud’enkov, Yu. Ya. published the artcileReaction of poly- and perfluoroalkyl perfluoroisopropyl ketones with secondary amines, Quality Control of 360-92-9, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1978), 477-9, database is CAplus.

RCOCF(CF₃)₂ [I; R = CF₃, HCF₂CF₂, H(CF₂)₄] reacted with morpholine at 60° to give 63.3-76.1% RCOX (X = morpholino) and (CF₃)₂CFH. I (R = CF₃, HCF₂) reacted analogously with Et₂NH, I (R = HCF₂CF₂) gave 24.0-47.9% HCF₂CF₂COX (X = NEt₂, NHEt) and 9.4% HCF₂CF₂CH(OH)CF(CF₃)₂ and I [R = H(CF₂)₄] gave 38.1% H(CF₂)₄CONHEt and 35.1% H(CF₂)₄CH(OH)CF(CF₃)₂. HCF₂CF₂COX (X = NEt₂, NHEt) were also prepared from (HCF₂CF₂CO)₂O and the amines.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C20H28BNO5, Quality Control of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics