Category: 360-92-9

Amaral, Miriam C. S. published the artcileCharacterization of residual organic compounds of aerobic degradation of landfill leachate, SDS of cas: 360-92-9, the publication is Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering (2017), 52(7), 665-672, database is CAplus and MEDLINE.

The purpose of this article is to characterize and compare the residual COD of raw landfill leachate and its low and high mol. weight fractions before and after aerobic degradation process. The low and high mol. weight fractions (<10 kDa and >10 kDa, resp.) were obtained by the use of an ultrafiltration cell. Samples of the fractions with mol. weights 10 kDa, as well as the raw leachate, were characterized in terms of COD, protein, carbohydrate and lipid concentration and by biodegradability test. The compound identification of all samples was carried out using gas chromatog. coupled with mass spectrometry (GC/MS). The results show that the landfill leachate studied is constituted of approx. 60% of compounds with mol. weight <10 kDa. Approx. 80% of the compounds identified in the leachate had been degraded. This is an indication that most of the compounds that constitute the significant fraction of residual COD correspond to intermediate products and products of condensation of affluent compounds or had been generated during the degradation (SMP). Similar compounds were identified in all effluents of the degradation assay, suggesting the presence of SMP. These compounds, predominantly aliphatic and esters, are characterized by high mol. weight and probable refractory nature.

Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, SDS of cas: 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Schmidt, Joachim published the artcileBasic hydrolysis of N-alkyltrifluoroacetamides in 50% ethanol. Are these reactions suitable for determining steric substituent constants?, Category: amides-buliding-blocks, the publication is Wissenschaftliche Zeitschrift der Paedagogischen Hochschule Karl Liebknecht Potsdam (1987), 31(1), 23-31, database is CAplus.

The velocity constants for the second-order basic hydrolysis of CF₃CONRR¹ [R = Me, Et, Pr, Me₂CH, Bu, Me₂CHCH₂, Me(CH₂)_n (n = 4, 5, 6, 7), Me₂CHCH₂CH₂, Me₃C, R¹ = H (I); R = R¹ = H, Me, Et, Pr] in 50% aqueous EtOH, determined at ≤75% reaction, had good LFER with Charton υ(OR) or υ(NHR) steric constants The extensive deprotonation of I was kinetically characterized.

Wissenschaftliche Zeitschrift der Paedagogischen Hochschule Karl Liebknecht Potsdam published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Joris, L. published the artcileEffects of polar aprotic solvents on linear free-energy relations in hydrogen-bonded complex formation, Application of N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Journal of the American Chemical Society (1972), 94(10), 3438-42, database is CAplus.

The effects of polar aprotic solvents on linear free-energy relations in H-bonded complex formation were studied. The behavior of strong pKa bases has suggested the utility of the concept of solvent-induced (partial) ionization in H-bonded complexes as distinct from partial H-bonded ion-pair formation or ionic dissociation

Journal of the American Chemical Society published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application of N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Joullie, Madeleine M. published the artcileReactions of amines with esters of polyhalogenated acids, Category: amides-buliding-blocks, the publication is Journal of the American Chemical Society (1955), 6662-3, database is CAplus.

Me₂C:CH₂ passed 1 hr. into 37 g. CF₃CO₂H (I) at 50°, and the mixture allowed to stand overnight, treated with more Me₂C:CH₂ until the heat evolution ceased, and fractionated yielded 75% CF₃CO₂CMe₃ (II), b₆₀ 30°, b₇₆₀ 83°, n_D²⁵ 1.3300. An appropriate ester treated gradually with the appropriate amine, and the mixture allowed to stand overnight and fractionated gave the corresponding amide; the mixtures with II were allowed to stand 4 days before fractionation. In this manner were prepared the following amides of I (m.p. or b.p./mm., % yield, n_D²⁵ given): di-Et, 30°/2, 60, 1.3780; piperidide, 44°/1, 84, 1.4153; morpholide, 47°/1, 87, 1.4177. C₂F₅CO₂H: Bu, 48°/1, 80, 1.3642; morpholide, 59°/1 (m.p. 46-7°), 85, -. C₃F₇CO₂H: Bu, 56°/2, 80, 1.3568; piperidide, 57°/2, 85, 1.3846; pyrrolidide, 65°/2, 76, 1.3755; morpholide, 72°/2, 89, 1.3850; piperidide of CHF₂CO₂H, 66°/3, 85, 1.4500. CClF₂CO₂H piperidide, 98°/10, 90, 1.4520. CHCl₂CO₂H pyrrolidide, 120°/2, 75, 1.5182.

Journal of the American Chemical Society published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Graham, Laurine L. published the artcileChemical shift assignments in N,N-disubstituted trifluoroacetamides, Computed Properties of 360-92-9, the publication is Organic Magnetic Resonance (1972), 4(2), 335-42, database is CAplus.

Due to hindered rotation about the central C-N bond in N,N-disubstituted trifluoroacetamides, CF3CONR1R2, two resonance peaks are usually observed for each proton in R1 and R2. Chem. shift assignments are made for the following amides: R1 = R2 = Me; R1 = R2 = Et; R1 = Me, R2 = Me2CH; R1 = Me, R2 = Bu; R1 = Me, R2 = cyclohexyl; R1 = R2 = Me2CH; R1 = Me2CH, R2 = cyclohexyl. Amides, where R1 = R2 = Me2CH and R1 = Me2CH, R2 = cyclohexyl, show an inversion of the relative chem. shift for both the methine and methyl protons of the 2-propyl group as compared with the amide where R1 = Me, R2 = Me2CH. For non-fluorinated amides, aromatic solvents shift the trans alkyl peaks to higher field faster than those cis (to the carbonyl oxygen atom); however, this generalization does not apply to all trifluoroacetamide proton peaks.

Organic Magnetic Resonance published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Computed Properties of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Spagnolo, Piero published the artcileOne-pot preparation of isomeric acetyl- and 2,2,2-trifluoroacetylazidothiophenes by selective bifunctionalization of dibromothiophenes via halogen-lithio exchange, COA of Formula: C6H10F3NO, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1996), 963-964, database is CAplus.

A series of isomeric acetyl- (I, R = H) and 2,2,2-trifluoroacetylazidothiophenes (I, R = F) are prepared from 2,3-, 3,4-, and 2,5-dibromothiophenes via a one-pot procedure entailing stepwise halogen-lithium exchange and successive reaction of the resulting thienyllithium derivatives with tosyl azide and either N,N-dimethylacetamide or N,N-diethyl-2,2,2-trifluoroacetamide.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C7H6BF3O2S, COA of Formula: C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Moniruzzaman, Mohammad published the artcileElectrochemical approach to trifluoroacetamide synthesis from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) catalyzed by B₁₂ complex, HPLC of Formula: 360-92-9, the publication is Journal of Porphyrins and Phthalocyanines (2022), 26(6/7), 419-426, database is CAplus.

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochem. method with the B12 complex as a catalyst under mild conditions, in open air at room temperature Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.

Journal of Porphyrins and Phthalocyanines published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, HPLC of Formula: 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lawrence, Elliot J. published the artcile3-Aryl-3-(trifluoromethyl)diazirines as Versatile Photoactivated “Linker” Molecules for the Improved Covalent Modification of Graphitic and Carbon Nanotube Surfaces, Product Details of C6H10F3NO, the publication is Chemistry of Materials (2011), 23(16), 3740-3751, database is CAplus.

3-Aryl-3-(trifluoromethyl)diazirines are shown to be synthetically useful photoactivated carbene precursors that can be used as mol. “tethers” to facilitate the improved covalent surface modification of graphitic carbon and carbon nanotubes with a potentially large variety of chem. species. Proof-of-concept is demonstrated by the synthesis, as well as spectroscopic and electrochem. characterization, followed by photoactivated attachment of the organometallic diazirine derivative, 3-[3-(trifluoromethyl)diazirin-3-yl]phenyl ferrocene monocarboxylate, to the surface of vitreous carbon, and also to two different morphologies of multiwalled carbon nanotubes (“bamboo-like” and “hollow-tube”, denoted as b-MWCNTs and h-MWCNTs, resp.). The latter differ only in the relative amounts of “edge-plane-like” defect sites (at the termini of the nanotubes) and “basal-plane-like” pristine sidewall regions. The facile covalent coupling of the ferrocenyl “probe” moiety to the diazirine “linker” was confirmed by UV-vis, ¹H and ¹⁹F NMR spectroscopy, and cyclic voltammetry (CV). Upon exposure to UV irradiation in the presence of graphitic materials, the resulting covalent surface attachment of the ferrocenyl groups via the diazirine “linker” was characterized by Raman and XPS and by CV experiments performed in nonaqueous electrolyte. The surface coverage of 3-[3-(trifluoromethyl)diazirin-3-yl]phenyl ferrocene monocarboxylate, analyzed from both CV and XPS experiments was found to be 7%-11% of that estimated for a complete monolayer, and was 20-fold greater than that achieved in control experiments that employed conventional covalent modification strategies to form esters between ferrocene methanol and surface carboxylate groups on the graphitic materials. The surface loading of ferrocene groups on the b-MWCNTs was found to be only ca. 60%-70% that achieved on h-MWCNTs, reflecting the ability of the functionalized carbene intermediate formed upon photolysis of the parent diazirine to insert into C=C bonds in the otherwise relatively inert sidewalls of the nanotubes. This was further confirmed by Raman spectroscopic characterization, which revealed that the h-MWCNTs experienced significantly more sidewall functionalization than the b-MWCNTs, yet still retained good electronic conduction in electrochem. experiments The relative chem. stability of 3-aryl-3-(trifluoromethyl)diazirines, the ease with which they can be potentially be coupled to a large range of different organic, inorganic, and biol. species, and the enhanced surface loading that can be achieved as a result of the reactive carbene intermediate formed during their photolysis, render diazirines highly versatile and potent “linker” mols. for the development of chem. modified materials.

Chemistry of Materials published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Staab, Heinz A. published the artcileN-Trifluoroacetyl- and N-trichloroacetylimidazole, Name: N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Chemische Berichte (1962), 2070-2, database is CAplus.

The syntheses and reactions of N-trifluoroacetylimidazole (I) and N-trichloroacetylimidazole (II) are described. N,N’-Carbonyldiimidazole (III) (20.5 g.) in 100 cc. dry THF treated dropwise with 28.8 g. CF₃CO₂H in 80 cc. THF, cooled several hrs., and filtered gave imidazolium trifluoroacetate (IV), m. 136-7° (tetrahydrofuran); distillation of the filtrate yielded 14.4 g. I, b₁₄ 45-6°. Imidazole (V) (25.8 g.) in 120 cc. dry THF treated dropwise with cooling with 39.9 g. (CF₃CO)₂O in 50 cc. THF, filtered from the IV, and distilled gave 24.8 g. I. CCl₃CO₂H (39.1 g.) and 19.5 g. III in C₆H₆ gave in the usual manner imidazolium trichloroacetate (VI), m. 93-4.5° (decomposition) (CHCl₃), and from the filtrate 18.5 g. II, b_0.001 60-2°, m. 38.5-40°. (CCl₃CO)₂O (31.3 g.) added dropwise with cooling to 17.8 g. V in 170 cc. C₆H₆, filtered from the VI, and distilled yielded 21.7 g. II. I treated in Et₂O or THF at room temperature with an equivalent amount of an appropriate alc. gave the following CF₃CO₂R (R, % yield, m.p. or b.p./mm., and n²⁰_D given): cyclohexyl, 73, 148-9°/760, 1.3839; iso-Am, 74, 119-20°/760, 1.3513; Me₃C, 73, 83°/760, 1.3302 (at 25°); Ph, 75, 48-9°/16, 1.4187 (at 25°). II gave similarly the following CCl₃CO₂R (same data given): cyclohexyl, 81, 122.5-3.5°/14, 1.4805; iso-Am, 84, 97.5-98°/15, 1.4520; Me₃C, 78, 25-6°, -; Ph, 79, 124.5-25°/14, 1.5253. I treated at room temperature with an equivalent amount of an appropriate amine in THF or Et₂O and evaporated, and the residue washed with H₂O gave the corresponding amides of CF₃CO₂H (% yield, and m.p. or b.p./mm. given): diethylamide, 74, 157-8°/760; anilide, 83, 89-90°; 2-naphthylamide, 83, 146-7.5°; p-nitranilide, 84, 151-3°; carbethoxymethylamide, 51, 51°. II gave similarly the following amides of CCl₃CO₂H (same data given): diethylamide, 82, 26-7°; anilide, 90, 94.5-5.5°; N-methylanilide, 87, 72-2.5°. p-H₂NC₆H₄CO₂H (4.12 g.) and 10 g. I in Et₂O at room temperature gave 5.5 g. p-CF₃CONHC₆H₄CO₂H (VII), m. 284-5° with resolidification to a solid which does not melt up to 350°. A similar run with equivalent amounts of reactants gave only 38% VII. VII heated 1 h. at 300° gave with the elimination of CF₃CO₂H a polyamide of p-H₂NC₆H₄CO₂H.

Chemische Berichte published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C10H15ClO3S, Name: N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Reichstein, Alexandra published the artcileSynthesis and Structure-Activity Relationships of Lapacho Analogues. 1. Suppression of Human Keratinocyte Hyperproliferation by 2-Substituted Naphtho[2,3-b]furan-4,9-diones, Activation by Enzymatic One- and Two-Electron Reduction, and Intracellular Generation of Superoxide, SDS of cas: 360-92-9, the publication is Journal of Medicinal Chemistry (2012), 55(16), 7273-7284, database is CAplus and MEDLINE.

A series of linearly annelated lapacho quinone analogs substituted at the 2-position of the tricyclic naphtho[2,3-b]furan-4,9-dione system were synthesized and evaluated for their ability to suppress keratinocyte hyperproliferation using HaCaT cells as the primary test system. While very good in vitro potency with IC₅₀ values in the submicromolar range was attained with electron-withdrawing substituents, some compounds were found to induce plasma membrane damage, as evidenced by the release of LDH activity from cytoplasm of the keratinocytes. The most potent analog against keratinocyte hyperproliferation was the 1,2,4-oxadiazole I, the potency of which was combined with comparably low cytotoxic membrane damaging effects. Structure-activity relationship studies with either metabolically stable or labile analogs revealed that the quinone moiety was required for activity. Selected compounds were studied in detail for their capability to generate superoxide radicals both in isolated enzymic one- and two-electron reduction assays as well as in a HaCaT cell-based assay.

Journal of Medicinal Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, SDS of cas: 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics