Category: 359-38-6

Kuznetsova, O. V. published the artcileCorrelation analysis of quantum chemical data and the polarizability effect in H-complexes, Synthetic Route of 359-38-6, the main research area is correlation quantum chem data polarizability effect hydrogen bonded complex.

The study is concerned with anal. of the energies of formation (E), frequency shifts (Δν) in IR spectra, ionization potentials (IP) of H-complexes, hydrogen bond lengths (r), and spin densities (sd) in H-complexes involving radical cations, obtained from quantum chem. calculations for 20 series of H-complexes. It was for the first time established that the E, IP, r, and sd values and the changes in enthalpy (δH) depend not only on the inductive and resonance effects but also on the polarizability effect of the substituents bound to the donor and acceptor centers in the H-complexes. Interrelations between the polarizability effect and the mol. structure of H-complexes are considered.

Russian Chemical Bulletin published new progress about Bond length (hydrogen bond). 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Synthetic Route of 359-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pendlebury, Martyn H. published the artcileStructural dependence of the inductive effect. VII. Effects of 1-substituents upon geminal proton-fluorine spin-spin coupling constants (2JFH), Application In Synthesis of 359-38-6, the main research area is NMR fluorine hydrogen coupling; fluorine hydrogen spin coupling; fluoroalkane NMR substituent effect; fluoroacetamide NMR substituent effect; substituent effect NMR coupling.

The effects of 1-substituents on 2JFH in mols. in which the nuclei were bonded to C and to Si were analyzed empirically. The nonadditivity of such effects was discussed. A simple expression enabling 2jHf to be calculated in terms of the Huggins electronegativities of the substituents was given.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry published new progress about Alkanes Role: PRP (Properties). 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Application In Synthesis of 359-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Schaad, David R. published the artcileReactions of amides with zerovalent and divalent palladium and platinum complexes, Quality Control of 359-38-6, the main research area is methylplatinum photosubstitution amide triflamide trifluoroacetamide; methylpalladium photosubstitution amide triflamide trifluoroacetamide; palladium zerovalent divalent amide; platinum zerovalent divalent amide; hydroamination catalysis amidepalladium amideplatinum.

The reactions of amides (RCONH2 and CF3SO2NH2) with L2Pd(CH3)2 and L2Pt(CH3)2 and with transient L2Pt(0) to yield new complexes containing palladium- and platinum-amido nitrogen bonds are reported. Photolysis of Pt(C2O4)(PEt3)2 in the presence of amide generates products of the type trans-PtH(HNR)(PEt3)2 [R = SO2CF3 (1a), COCF3 (1b)]. Reaction of amides with trans-PtH(CH3)(PEt3)2 (2), cis-PdMe2(PEt3)2 (3), cis-PtMe2(PEt3)2 (4), PdMe2(dcpe) (5), PdMe2(dmpe) (6), and PtMe2(COD) (7) produces 1a,b, trans-PdMe(HNR)(PEt3)2 [R = SO2CF3 (3a), COCF3 (3b), COCF2H (3c), COPh (3d)], PtMe(HNR)(PEt3)2 [R = SO2CF3 (4a), COCF3 (4b)], PdMe(HNR)(dcpe) [R = SO2CF3 (5a), COCF3 (5b), COPh (5c)], PdMe(HNSO2CF3)(dmpe) (6a), and PtMe(HNR)(COD) [R = SO2CF3 (7a), COCF3 (7b)], resp. The stereochem. and topologies of the new compounds are established by multinuclear NMR spectroscopy. The relevance of these reactions to hydroaminium catalysis is discussed.

Organometallics published new progress about Coordinative photosubstitution reaction. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Quality Control of 359-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

He, Kan published the artcileIdentification of the Heme-Modified Peptides from Cumene Hydroperoxide-Inactivated Cytochrome P450 3A4, Related Products of amides-buliding-blocks, the main research area is cytochrome P450 3A4 heme peptide cumene hydroperoxide inactivation.

Cumene hydroperoxide-mediated (CuOOH-mediated) inactivation of cytochromes P 450 (CYPs) results in destruction of their prosthetic heme to reactive fragments that irreversibly bind to the protein. We have attempted to characterize this process structurally, using purified, 14C-heme labeled, recombinant human liver P 450 3A4 as the target of CuOOH-mediated inactivation, and a battery of protein characterization approaches [chem. (CNBr) and proteolytic (lysylendopeptidase-C) digestion, HPLC-peptide mapping, microEdman sequencing, and mass spectrometric analyses]. The heme-peptide adducts isolated after CNBr/lysylendopeptidase-C digestion of the CuOOH-inactivated P 450 3A4 pertain to two distinct P 450 3A4 active site domains. One of the peptides isolated corresponds to the proximal helix L/Cys-region peptide 429-450 domain and the others to the K-region (peptide 359-386 domain). Although the precise residue(s) targeted remain to be identified, we have narrowed down the region of attack to within a 17 amino acid peptide (429-445) stretch of the 55-amino acid proximal helix L/Cys domain. Furthermore, although the exact structures of the heme-modifying fragments and the nature of the adduction remain to be established conclusively, the incremental masses of ≈ 302 and 314 Da detected by electrospray mass spectrometric analyses of the heme-modified peptides are consistent with a dipyrrolic heme fragment comprised of either pyrrole ring A-D or B-C, a known soluble product of peroxidative heme degradation, as a modifying species.

Biochemistry published new progress about Enzyme functional sites, active. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics