Category: 359-38-6

Utine, Canan Asli published the artcileEffects of Preoperative Topometric Indices on Visual Gain After Intracorneal Ring Segment Implantation For Keratoconus., COA of Formula: C2H3F2NO, the main research area is .

OBJECTIVES: To assess the corneal topometric parameters that can be predictive for better visual gain after intracorneal ring segment (ICRS) implantation in eyes with keratoconus. METHODS: A total of 42 eyes of 32 patients who underwent ICRS implantation at Dokuz Eylul University, Deparment of Ophthalmology, Cornea Divison were included. Changes in uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), refractive errors, and corneal topometric indices measured using Scheimpflug topography (Pentacam, Oculus) were evaluated retrospectively. RESULTS: After creation of intrastromal tunnels of 5.01±0.03 mm inner diameter, 5.71±0.03 mm outer diameter and at 384.21±34.12 μm depth, 1 or 2 ICRS of 150 to 350 µm thickness and 90 to 210° arc length were implanted. Preoperative UDVA of 0.09±0.10 and CDVA of 0.29±0.14 Snellen lines improved postoperatively to 0.42±0.26 and 0.62±0.24, respectively (P<0.001 for both). Preoperative spherical equivalent of -6.35±4.58D and refractive astigmatism of -5.89±2.40D decreased to -3.59±3.86 and -2.25±1.66D, retrospectively (P<0.001 for both). Strong negative correlations were detected between preoperative mean simulated keratometry (SimKavg)/index of surface variance (ISV) and changes in UDVA/CDVA (P<0.01, for all). Postoperative change in ISV was positively correlated with thicknesses of implanted rings. Change in topographical keratoconus classification was positively and change in index of vertical asymmetry was negatively correlated with number of implanted rings (P<0.05 for all). CONCLUSIONS: Preoperative ISV value seems to be beneficial in predicting visual gain after ICRS implantation, in addition to SimKavg. Future work on new nomograms for ICRS selection that include ISV, besides refractive, topographic, and cone location data, is warranted. Eye & contact lens published new progress in MEDLINE about 359-38-6, 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, COA of Formula: C2H3F2NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Claeys, E. G. published the artcileHigasi’s method for the determination of electric dipole moments, Application of 2,2-Difluoroacetamide, the main research area is .

The Higasi equation for calculating the dipole moment (CA 43, 7764a) does not require determination of n or calculation of molar refraction. Application to air- and moisture-sensitive compounds would be useful, to avoid the exposure these measurements require. Organometallic compounds of As and Sn and several halo derivs of acetamide and acetaldehyde in several solvents were used and the values for elec. moment were compared, for the classical method, and Higasi’s treatment. Agreement was within exptl. error; there was a maximum deviation of 0.17D., but an average deviation of only 0.05 D. for 14 compounds Solvent effects on measured moments are counted for both classical and Higasi methods.

Bulletin des Societes Chimiques Belges published new progress about Air. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Application of 2,2-Difluoroacetamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pendlebury, M. H. published the artcileBarriers to rotation about carbon-nitrogen bonds. I. Rotation about the carbon-nitrogen bond in mono-, di-, and trifluoroacetamide, and deuterium isotope effects upon fluorine-19 shielding, Synthetic Route of 359-38-6, the main research area is fluoroacetamide NMR; acetamide fluoro NMR; rotation carbon nitrogen fluoroacetamide; fluorine shielding fluoroacetamide.

The 19F NMR spectra of FCH2CONH2 (I) and F2CHCONH2 (II) are used to derive the activation parameters for rotation about the C-N bond; it is not possible to obtain useful results for CF3CO2NH2 (III). A total line shape anal. is used. Unusually large D isotope effects on the shielding of the 19F nucleus were observed for N-deuterated derivatives The magnitude of the isotope effect is different for I-III, and in the mono-deuterated species the isotope effect is different for cis and trans rotational isomers.

Organic Magnetic Resonance published new progress about Bond. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Synthetic Route of 359-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Schaad, David R. published the artcileActivation of amide nitrogen-hydrogen bonds by iron and ruthenium phosphine complexes, Synthetic Route of 359-38-6, the main research area is amide activation iron ruthenium complex; nitrogen hydrogen bond activation amide; hydride ruthenium iron activation amide.

The complexes cis-RuHR(dmpe)2 (R = naphthyl, dmpe = Me2PCH2CH2PMe2), cis-FeH2(dmpe)2, and FeH(C6H4PPhCH2CH2PPh2)(DPPE) readily activate the N-H bonds of amides, yielding trans-MH(NHCOR1)L2 (R1 = COCF3, COC6F5, COMe, etc., L = diphosphine) products. The formation and stability of the product depend on the natures of both the metal complex and the amide employed. For the more acidic amides (e.g., trifluoroacetamide and triflamide), product formation appears to proceed via protonation of the metal complex by the amide. In the presence of excess amide, trans-RuH(NHCOR)(dmpe)2 undergoes rapid exchange of the amido ligand but not the hydride ligand.

Journal of the American Chemical Society published new progress about H-N bond. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Synthetic Route of 359-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Iwasaki, Machio published the artcileE.S.R. spectra of γ-irradiated polycrystalline powders of some fluorine-containing compounds, Product Details of C2H3F2NO, the main research area is .

The powder spectra of γ-irradiated salts and amides of some fluorinated acids were interpreted, based on the spectral shapes of the α-F hyperfine-coupling line. Because of the large anisotropy of the α-F coupling tensor, it was possible to observe the shoulders corresponding to the maximum principal value of the coupling tensor. The separation between the wing patterns and the wing hyperfine structures made it possible to identify the radical species produced. The probable radicals were the ones formed by the removal of the atoms attached to the α C atom.

Journal of Chemical Physics published new progress about Gamma ray. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Product Details of C2H3F2NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Herman, M. A. published the artcileHalogenated aliphatic compounds. III. Infrared spectra of solid halogenated acetamides, Application of 2,2-Difluoroacetamide, the main research area is .

Spectra of fluoro- (I), difluoro- (II), trifluoro- (III), chloro- (IV), dichloro- (V), and trichloroacetamide (VI) are determined in KBr pellets, with frequency in cm.-1, intensity, and assignment of bands given. The shift of the “”amide I”” band to higher frequencies with increasing halogen content, while the “”amide II”” band is displaced relatively little, supports the correlation of these bands with the CO and NH2 portions of the amide group, resp.

Bulletin des Societes Chimiques Belges published new progress about IR spectra. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Application of 2,2-Difluoroacetamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Woronick, Charles L. published the artcileSpectrophotofluorometric determination of the dissociation constants of amides from the enzyme-reduced coenzyme complex of liver alcohol dehydrogenase(ADH), Product Details of C2H3F2NO, the main research area is .

cf. ibid. 15(10), 2062(1961). A mixture of ADH and reduced diphosphopyridine nucleotide (DPNH) in solution, which contains a fluorescent ADH-DPNH complex, was titrated with solutions of amides while the fluorescence at 410 mμ was measured. Dissociation constants were obtained by plotting the reciprocal of the change in fluorescence intensity vs. the reciprocal of the amide concentration (method of Winer and Theorell, CA 56, 9102g). Values of KER.I. are tabulated for 17 amides (E = enzyme, R = DPNH, I = inhibitor (amide)). These agree well with the Michaelis constants obtained previously. The values are also plotted according to the Taft ρ*σ* equation and the correlations are discussed.

Acta Chemica Scandinavica published new progress about Dissociation. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Product Details of C2H3F2NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gundersena, Snefrid published the artcileThe molecular structure, conformation, potential to internal rotation and force field of 2,2-difluoroacetamide as studied by gas electron diffraction and quantum-chemical calculations, Category: amides-buliding-blocks, the main research area is difluoroacetamide mol structure conformation potential function DFT MP2 HF.

CHF2CONH2 was studied by electron diffraction (ED), ab initio HF, MP2 and d. functional theory calculations using a 6-311++G** basis set. The calculations give 1 conformation where 1 of the C-F bonds is almost orthogonal to the C-C-O-N skeleton plane and a planar NH2 group except for MP2, which predicts a slightly pyramidal NH2 group. The mol. force field was determined, and the fundamental frequencies were assigned and compared with the limited spectroscopic data available for this mol. The refined structural parameters were determined using constrained ED, i.e., ab initio results are included as constraints in the anal. Uncertainties are 1 standard deviation from least-squares refinement using a diagonal weight matrix and inclusion of the uncertainty in the electron wavelength. The structural parameters are compared with those of related amides. The barrier height at the syn conformation, V0, and the min. of the potential-energy function, φmin, are determined as 2.8(5) kJ mol-1 and 35(1)°, resp., which agree with theor. calculations The barrier height at the anti conformation, V180, was fixed to its calculated value of 20.3 kJ mol-1.

Journal of Molecular Structure published new progress about Conformation. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gundersen, Snefrid published the artcileThe molecular structure, conformation, potential to internal rotation and force field of 2,2-difluoroacetamide as studied by gas electron diffraction and quantum-chemical calculations, Application In Synthesis of 359-38-6, the main research area is difluoroacetamide mol structure conformation potential function DFT MP2 HF.

CHF2CONH2 was studied by electron diffraction (ED), ab initio HF, MP2 and d. functional theory calculations using a 6-311++G** basis set. The calculations give 1 conformation where 1 of the C-F bonds is almost orthogonal to the C-C-O-N skeleton plane and a planar NH2 group except for MP2, which predicts a slightly pyramidal NH2 group. The mol. force field was determined, and the fundamental frequencies were assigned and compared with the limited spectroscopic data available for this mol. The refined structural parameters were determined using constrained ED, i.e., ab initio results are included as constraints in the anal. Uncertainties are 1 standard deviation from least-squares refinement using a diagonal weight matrix and inclusion of the uncertainty in the electron wavelength. The structural parameters are compared with those of related amides. The barrier height at the syn conformation, V0, and the min. of the potential-energy function, φmin, are determined as 2.8(5) kJ mol-1 and 35(1)°, resp., which agree with theor. calculations The barrier height at the anti conformation, V180, was fixed to its calculated value of 20.3 kJ mol-1.

Journal of Molecular Structure published new progress about Conformation. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Application In Synthesis of 359-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Donetti, Arturo published the artcileN-(Fluoroethyl)(imidazolylphenyl)formamidines. The issue of the active species of mifentidine, SDS of cas: 359-38-6, the main research area is fluoroethylaminomethyleneaminophenylimidazole preparation antihistaminic; mifentidine fluorinated analog antihistaminic; substituent fluorine mifentidine analog; basicity fluorinated analog mifentidine.

(Imidazolylphenyl)formamidines I (R = CH2F, CHF2, CF3) were prepared to test the effect of F substitution on basicity and, then, on H2-antagonist affinity in comparison with I (R = Me) taken as a model of mifentidine. Imidazolylphenyl isothiocyanate, obtained by reaction of 4-(aminophenyl)imidazole with CS2 and ClCO2Et, was condensed with RCH2NH2.HCl to give thioureas. Desulfurization of these thioureas by Raney Ni furnished I. Increasing F substitution in I decreased the basicity of the formamidino group substantially while having a modest effect on the imidazole portion. Affinity at the H2 receptors, evaluated from antagonism of histamine-stimulated chronotropic response on guinea pig atria, increased with F substitution. Thus, H2-receptor antagonist affinity in the mifentidine series is mostly dependent on the availability of the neutral species, supporting the hypothesis that mifentidine acts through the neutral species.

Journal of Medicinal Chemistry published new progress about Antihistamines. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, SDS of cas: 359-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics