Category: 35303-76-5

Adding a certain compound to certain chemical reactions, such as: 35303-76-5, name is 4-(2-Aminoethyl)benzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35303-76-5, HPLC of Formula: C8H12N2O2S

General procedure: Starting dichlorotriazinyl benzenesulfonamide (1 mmol; 0.320 g of4- [(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzene-1-sulfonamide, 0.334 g of4-{[(4,6-dichloro-1,3,5-triazin-2-yl)amino]methyl}benzene-1-sulfonamide or 0.348 g of4-{2-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-ethyl}benzene-1-sulfonamide)) was dissolved in20 mL of DMF. Then 1 mmol (0.138 g) of solid anhydrous potassium carbonate was added in smallportions and the mixture was stirred for 10 min. Then 1 mmol of the appropriate nucleophile wasadded portion wise. Finally, 2.5% mol. of supported Cu(I) ions (312 mg of catalyst) was addedinto the reaction mixture. Reaction was stirred at 35 C until the maximum conversion of startingmaterial is achieved (monitored by TLC). After completion of the first reaction step, 1 mmol of thesecond nucleophile and 1 mmol (0.138 g) of anhydrous potassium carbonate were added into thereaction mixture. The reaction mixture was then stirred at 100 C until the maximum conversion of anucleophile was determined (monitored by TLC). After completion of a reaction, the catalyst andsalt were filtered o. Crushed ice was then added into the solution and the formed precipitate wascollected by filtration. The crude product was dissolved in acetone and precipitated by the addition ofisopropyl alcohol.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(2-Aminoethyl)benzenesulfonamide, and friends who are interested can also refer to it.

Reference:
Article; Havrankova, Eva; Csoellei, Jozef; Pazdera, Pavel; Molecules; vol. 24; 19; (2019);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 35303-76-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35303-76-5 as follows.

4-(2-aminoethyl)benzenesulfonamide (0.86 mmol) was added to a THF solution (20 ml) of 1- (3-isocyanatopropyl) -4-methoxybenzene Gt; min. & Lt; / RTI & gt; The reaction mixture was stirred at 40-45¡ã C for 24 hours. The next day, TLC was used to confirm the termination of the reaction. The solvent was distilled off and ammonium chloride (100 ml), 1N HCl solution (50 ml) and ethyl acetate (100 ml) were added to the remaining residue. The organic layer was washed with brine and dried over sodium sulfate. The solvent was distilled off and the residue was adsorbed onto silica gel using methylene chloride. The title compound was then separated and purified by column chromatography using ethyl acetate and hexane

According to the analysis of related databases, 35303-76-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHUNGNAM NATIONAL UNIVERSITY INDUSTRY & ACADEMIC COOPERATION (IAC); JUNG, SANG HUN; WOO, SUN HEE; KIM, SANG KYUM; JEON, EUN SEOK; LEE, YOU JUNG; MANICKAM, MANOJ; JALANI HITESHKUMAR, HITESHKUMAR; SHARMA, NITI; (234 pag.)KR2015/111825; (2015); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 35303-76-5, The chemical industry reduces the impact on the environment during synthesis 35303-76-5, name is 4-(2-Aminoethyl)benzenesulfonamide, I believe this compound will play a more active role in future production and life.

A THF solution (20 ml) of 4- (4-isocyanatobutyl) benzene (1.71 mmol) and 4- (2-aminoethyl) benzenesulfonamide (20 ml) was stirred at 40-45 ¡ã C for 24 hours. The next day, the completion of the reaction was confirmed by TLC. The solvent was distilled off and ammonium chloride (100 ml), water (50 ml) and ethyl acetate (100 ml) were added to the remaining residue. The organic layer was treated with brine and dried over sodium sulfate. The solvent was distilled off and the resulting concentrate was adsorbed onto silica gel using methylene chloride. The mixture was purified by column chromatography using ethyl acetate in hexane to give the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(2-Aminoethyl)benzenesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Industry & Academic Cooperation in Chungnam National University (IAC); Jung, Sang-Hun; Woo, Sun-Hee; Kim, Sang- Kyum; Jeon, Eun-Seok; Lee, Yu-Jung; Meunikam, Manoj; Jalani, Hiteshkumar; Sharma, Niti; (205 pag.)KR2016/108281; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35303-76-5 as follows. COA of Formula: C8H12N2O2S

Step 4. (S)-tert-butyl 6-(bis((1-(2-tert-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)-2-(3-((S)-1-tert-butoxy-1,5-dioxo-5-(4-sulfamoylphenethylamino)pentan-2-yl)ureido)hexanoate A solution of (S)-4-(3-((S)-6-(bis((1-(2-tert-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)-1-tert-butoxy-1-oxohexan-2-yl)ureido)-5-tert-butoxy-5-oxopentanoic acid (80 mg, 0.098 mmol), 4-(2-aminoethyl)benzenesulfonamide (30 mg, 0.15 mmol), 2-(1-H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyl uronium hexafluorophosphate methanaminium (HATU, 50 mg, 0.17 mmol), and DIPEA (0.50 mL) in DMF (5 mL) was stirred at 40 ¡ãC overnight. The solvents were evaporated under reduced pressure to give a residue, which was purified by Biotage SP4 using a gradient of 0-20percent MeOH in DCM to give (S)-tert-butyl 6-(bis((1-(2-tet¡ãt-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)-2-(3-((S)-1-tert-butoxy-1,5-dioxo-5-(4-sulfamoylphenethylamino)pentan-2-yl)ureido)hexanoate (100 mg, 100percent). ESMS m/z: 501.9 (M/2+H)+.

According to the analysis of related databases, 35303-76-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Molecular Insight Pharmaceuticals, Inc.; Babich, John W.; Zimmerman, Craig N.; Joyal, John; Maresca, Kevin P.; Marquis, John; Lu, Genliang; Wang, Jian-cheng; Hillier, Shawn; (110 pag.)EP2706057; (2016); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35303-76-5, name is 4-(2-Aminoethyl)benzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H12N2O2S

General procedure: To a cooled solution of triphosgene (1.41mmol) in THF at 0¡ãC, a mixture of primary amine (3.52mmol) and N,N-diisopropylethylamine (DIPEA, 7.04mmol) was added. The reaction mixture was stirred at the same temperature for 30min and then the other amine (3.52mmol) was added. The reaction mixture was slowly allowed to attain ambient temperature and further stirred for 8h. After the completion of the reaction, water was added to the reaction mixture and extracted using ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure. The crude mixture was subjected to column chromatography to obtain the pure compounds.

According to the analysis of related databases, 35303-76-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Manickam, Manoj; Jalani, Hitesh B.; Pillaiyar, Thanigaimalai; Boggu, Pulla Reddy; Sharma, Niti; Venkateswararao, Eeda; Lee, You-Jung; Jeon, Eun-Seok; Son, Min-Jeong; Woo, Sun-Hee; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 1869 – 1887;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 35303-76-5, These common heterocyclic compound, 35303-76-5, name is 4-(2-Aminoethyl)benzenesulfonamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

During DMF (5mL) (S) -4- (3 – ((S) -6- (bis ((1- (2-tert-butoxy-2-oxoethyl)-lH-imidazol-2-yl) methyl) amino)-1-tert-butoxy-1-oxo-hexane-2-yl) ureido) -5-tert-butoxy-5-oxo-pentanoic acid(80mg, 0.098mmol), 4- (2- aminoethyl) benzenesulfonamide amide (30mg,0.15mmol), 2- (1-H-7- aza-benzotriazol-1-yl) -1,1,3,3-hexafluorophosphatetetramethyluronium methane aminium (HATU, 50mg , 0.17 mmol), and was DIPEAsolution containing a (0.50 mL) was stirred overnight at 40 ¡ã C. The solventwas evaporated under reduced pressure, and to produce a residue which was usinga gradient containing 0-20percent MeOH in DCM and purified by Biotage SP4, (S) -tert-butyl 6- (bis ( (1- (2-tert- butoxy-2-oxoethyl)-lH-imidazol-2-yl) methyl)amino) -2- (3 – ((S) -1-tert- butoxy-1,5-dioxo – 5-(4-sulfamoyl-phenethyl-amino) pentan-2-yl) ureido) hexane acid (100mg,Resultedin 100percent).

Statistics shows that 4-(2-Aminoethyl)benzenesulfonamide is playing an increasingly important role. we look forward to future research findings about 35303-76-5.

Reference:
Patent; MOLECULAR INSIGHT PHARMACEUTICALS INCORPORATED; BABICH, JOHN W; (133 pag.)JP5856247; (2016); B2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35303-76-5, name is 4-(2-Aminoethyl)benzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-(2-Aminoethyl)benzenesulfonamide

To a solution of 1- (3-isocyanatopropyl) -4-methoxybenzene (0.78 mmol) in THFWas added 4- (2-aminoethyl) benzenesulfonamide (0.86 mmol) at room temperature to a solution (20 ml)Was slowly added over 10-15 minutes. The reaction mixture was stirred at 40-45 [deg.] C for 24 hours. The next day TLC confirmed the termination of the reaction. The solvent was distilled off and ammonium chloride (100 & lt; RTI ID = 0.0 & gt;Ml), 1N HCl solution (50 ml) and ethyl acetate (100 ml). The organic layer was washed with brine and then dried with sodium sulfate. The solvent was distilled off and the residue was adsorbed onto silica gel using methylene chloride. The title compound was then purified by column chromatography using ethyl acetate and hexane.

According to the analysis of related databases, 35303-76-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Industry & Academic Cooperation in Chungnam National University (IAC); Jung, Sang-Hun; Woo, Sun-Hee; Kim, Sang- Kyum; Jeon, Eun-Seok; Lee, Yu-Jung; Meunikam, Manoj; Jalani, Hiteshkumar; Sharma, Niti; (205 pag.)KR2016/108281; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35303-76-5, name is 4-(2-Aminoethyl)benzenesulfonamide, A new synthetic method of this compound is introduced below., Computed Properties of C8H12N2O2S

General procedure: (10 mmol) of 3,4-dimethoxyphenethylamine (1.1 mmol) and DIPEA (2.2 mmol) was slowly added to a THF solution (10 ml) of triphosgene (0.44 mmol) And stirred for 30-45 minutes. Then, a solution of 1-phenyl-1,2,3,4-tetrahydroisoquinoline (1.1 mmol) in THF (10 ml) was added and stirred overnight. The salt was filtered, and the filtrate was evaporated and column chromatography (EA: Hexane) was carried out to obtain the title compound.

The synthetic route of 35303-76-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHUNGNAM NATIONAL UNIVERSITY INDUSTRY & ACADEMIC COOPERATION (IAC); JUNG, SANG HUN; WOO, SUN HEE; KIM, SANG KYUM; JEON, EUN SEOK; LEE, YOU JUNG; MANICKAM, MANOJ; JALANI HITESHKUMAR, HITESHKUMAR; SHARMA, NITI; (234 pag.)KR2015/111825; (2015); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 35303-76-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35303-76-5 name is 4-(2-Aminoethyl)benzenesulfonamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 3- (4-fluorophenyl) propan-l-amine hydrochloride(2.11 mmol) in THF (10 ml)Was added DIPEA (6.32 mmol) and triphosgene (0.843 mmol)And the reaction mixture was stirred at 0 ¡ã C for 30 minutes.Then, 4- (2-aminoethyl) benzenesulfonamide (2.11 mmol) was added thereto,The reaction mixture was warmed to room temperature and stirred for 16 hours.To the reaction mixture was added 10percent [v / v] sodium hydrogencarbonate solution (20 ml) and extracted with ethyl acetate (3×50 ml). The ethyl acetate layer was collected and dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude extract thus obtained was purified by silica gel flash column chromatography (eluting with hexane solution containing 50 to 80percent [v / v] ethyl acetate) to give 4- – (3- (3- (4-fluorophenyl) propyl) ureido) ethyl) benzenesulfonamide was obtained

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(2-Aminoethyl)benzenesulfonamide, and friends who are interested can also refer to it.

Reference:
Patent; The Industry & Academic Cooperation in Chungnam National University (IAC); Jung, Sang-Hun; Woo, Sun-Hee; Kim, Sang- Kyum; Jeon, Eun-Seok; Lee, Yu-Jung; Meunikam, Manoj; Jalani, Hiteshkumar; Sharma, Niti; (205 pag.)KR2016/108281; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics