Rowan, Andrew S. published the artcilePreparative access to medicinal chemistry related chiral alcohols using carbonyl reductase technology, Synthetic Route of 35203-88-4, the main research area is carbonyl reductase chiral alc stereoselective reduction.
Libraries of highly enantioenriched secondary alcs. in both enantiomeric forms were synthesized by enzymic reduction of their parent ketones using selectAZyme carbonyl reductase (CRED) technol. Com. available CREDs were able to reduce a range of substrate classes efficiently and with very high enantioselectivity. Matching substrate classes to small subsets of CREDs enabled the fast development of preparative bioredns. and the rapid generation of 100-1500 mg samples of chiral alcs. in typically >95% ee and the majority in â?9.0% ee. The conditions for small scale synthesis were then scaled up to 0.5 kg to deliver one of the chiral alcs., (S)-1-(4-bromophenyl)-2-chloroethanol, in 99.8% ee and 91% isolated yield.
Tetrahedron: Asymmetry published new progress about Enantioselective synthesis. 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, Synthetic Route of 35203-88-4.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics