Category: 34813-49-5

Electric Literature of 34813-49-5, A common heterocyclic compound, 34813-49-5, name is 2-Methylpropane-2-sulfonamide, molecular formula is C4H11NO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 22 (RS)-S-{4-[(5-Bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}pyrimidin-2-yl)amino]phenyl}-N-(tert-butylsulphonyl)-S-methylsulphimide Preparation of the Final ProductProduct 250 mg (0.63 mmol) of (R)-3-[{5-bromo-2-(4-methylsulphanylphenylamino) pyrimidin-4-yl)}amino]-2-methylbutan-2-ol (compound 9.1), 129 mg (0.94 mmol) of tert-butylsulphonamide, 221 mg (1.01 mmol) of iodosobenzene and 222 mg (0.63 mmol) of iron(III)acetylacetonate are weighed into a flask, and 6 ml of acetonitrile are added. The mixture is stirred at room temperature for 250 hours and then concentrated in a rotary evaporator. The remaining residue is purified by chromatography (dichloromethane/ethanol 8:2). 15 mg (0.03 mmol; yield: 4%) of the product are obtained. 1H-NMR (DMSO): 9.74 (s, 1H), 8.09 (s, 1H), 7.92 (m, 2H), 7.74 (m, 2H), 6.11 (d, 1H), 4.04 (m, 1H), 2.94 (s, 3H), 1.11 (m, 18H).

The synthetic route of 34813-49-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Luecking, Ulrich; Nguyen, Duy; von Bonin, Arne; von Ahsen, Oliver; Siemeister, Gerhard; Jautelat, Rolf; Doecke, Wolf-Dietrich; US2008/58358; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 34813-49-5, name is 2-Methylpropane-2-sulfonamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 34813-49-5

General procedure: Inside a N2 filled glovebox, benzenesulfonamide (250 mg, 1.590 mmol) and copper(I) iodide (15.14 mg, 0.080 mmol), 4-toluene bromide (326mg, 1.91 mmol), potassium carbonate (550 mg, 3.98 mmol), Acetonitrile (4 mL), and N1,N2dimethylethane-1,2-diamine (70.1 mg, 0.795 mmol) was charged into a vial. The vial was then heated to 70 oC for 8hr, LC indicated >97% conversion of benzenesulfonamide. The reaction mixture was then cooled to room temperature. 2N HCl (4mL) was added slowly, followed by EtOAc extraction (5mL x 3). The organic layers were combined, concentrated, and flash chromatographed (SiO2, 20:1–> 3:1 Heptane:EtOAc) to give N(p-tolyl) benzene sulfonamide as white solids (380 mg, 97%).

The synthetic route of 2-Methylpropane-2-sulfonamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Xiang; Guram, Anil; Ronk, Michael; Milne, Jacqueline E.; Tedrow, Jason S.; Faul, Margaret M.; Tetrahedron Letters; vol. 53; 1; (2012); p. 7 – 10;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 34813-49-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34813-49-5, name is 2-Methylpropane-2-sulfonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 86 4-(2-Methyl-propane-2-sulfonylaminocarbonyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carboxylic acid (4-iodo-3-methyl-phenyl)-amide. A suspension of 5′-(4-iodo-3-methyl-phenylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid (50 mg, 0.11 mmol) in CH2Cl2 (5 mL) was treated with EDCI (60 mg, 0.31 mmol), t-butyl sulfonamide (18 mg, 0.13 mmol) and a catalytic amount of DMAP. After stirring at rt overnight the mixture was partitioned between CH2Cl2 and water. The CH2Cl2 layer was then collected and evaporated. The product was isolated after a purification with a silica gel column and 2-5% MeOH in CH2Cl2 and a precipitation out of warm CH2Cl2 with excess of hexanes (15 mg, Yield:24%). HRMS m/z calcd for C23H29N4O4SI [M+H]+: 585.1027; Found: 585.1032.

The synthetic route of 2-Methylpropane-2-sulfonamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Madrigal Pharmaceuticals, Inc.; BOLIN, David, R.; CHEUNG, Adrian, Wai-hing; HAMILTON, Matthew, Michael; MARCOPULOUS, Nicholas; McDERMOTT, Lee, Apostle; QIAN, Yimin; EP2350311; (2013); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34813-49-5, name is 2-Methylpropane-2-sulfonamide, A new synthetic method of this compound is introduced below., Recommanded Product: 34813-49-5

Example 11.1N-{4-[(3,5-Dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide{3,5-Dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid (example 1.1, 250 mg, 0.58 mmol), 2-methylpropane-2-sulfonamide (95 mg, 0.70 mmol), 1,3-dicyclohexylcarbodiimid (143 mg, 0.70 mmol) and 4-dimethylaminopyridine (85 mg, 0.70 mmol) in 2.5 ml dichloromethane were stirred for 3 h at 30 C. The solvent was removed under reduced pressure and the residue was purified by MPLC (silica gel, CH2Cl2/methanol 95:5).Yield: 51 mgESI mass spectrum: [M+H]+=551Retention time HPLC: 1.34 min (method D).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/28938; (2012); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics