Category: 34801-09-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34801-09-7, name is N-(2-Aminophenyl)acetamide, A new synthetic method of this compound is introduced below., Formula: C8H10N2O

General procedure: A mixture of 1.00 g (5.2 mmol) of compound 1a and 0.78 g (5.2 mmol) of N-(2-amino-phenyl)acetamide in 10 mL of ethanol was refluxed for 1 h. The mixture was cooled and evaporated by half, and the yellow solid was filtered off. Yield 1.20 g (71%), mp 130-132C (decomp., from EtOH). IR spectrum, nu, cm -1 : 3272 (NH, OH), 1715 (C=O). 1 H NMR spectrum, delta, ppm: 2.11 s (3H, Me), 6.38 s (1H, 3-H), 7.07 m (1H, H arom ), 7.17 m (2H, H arom ), 7.32 m (1H, H arom ), 7.49-7.60 m (3H, H arom ), 7.96 m (2H, H arom ), 9.82 s (1H, NH), 11.61 s (1H, NH). 13 C NMR spectrum, delta C , ppm: 22.8 (Me), 95.3 (C 3 ); 122.6, 125.1, 125.9, 127.1, 128.2, 128.5, 128.9, 130.3, 131.9, 138.5 (C arom ); 151.9 (C 2 ), 165.2 (COOH), 168.8 (CONH), 189.3 (COPh). Mass spectrum: m/z 325.15 [M + H] + . Found, %: C 66.59; H 4.87; N 8.44. C 18 H 16 N 2 O 4 . Calculated, %: C 66.66; H 4.97; N 8.64. [M + H] + 325.12

The synthetic route of 34801-09-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Stepanova; Dmitriev; Maslivets; Russian Journal of Organic Chemistry; vol. 55; 3; (2019); p. 402 – 405; Zh. Org. Khim.; vol. 55; 3; (2019); p. 469 – 473,5;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

34801-09-7, Name is N-(2-Aminophenyl)acetamide, 34801-09-7, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

General procedure (Method A): To a solution of aniline (32.25 mmol) in 30 ml of benzene was added p-TSA (12.25 g, 64.5 mmol), TEOF (4.7 g, 32.25 mmol), CuCl (10 mol %) at rt, mixture was heated to 50 C. Maintaining 50 C, powdered NaNO2 (2.09 g, 32.25 mmol) was added portion wise over 15 min, frothing was observed during the addition which subsided. The reaction mixture was maintained at the same temperature for 30 min to complete the reaction, monitored by TLC. The reaction mixture was cooled to rt, filtered to remove the solid precipitated, washed with EtOAc and organic layer was evaporated to dryness to get sticky residue, which was extracted with petroleum ether (60-80) followed by evaporation of solvent to yield the crude biaryl. It was purified by recrystallization from methanol/column chromatography ethyl acetate/petroleum ether (0.5:10) as eluent.

Statistics shows that N-(2-Aminophenyl)acetamide is playing an increasingly important role. we look forward to future research findings about 34801-09-7.

Reference:
Article; Chaturbhuj, Ganesh U.; Akamanchi, Krishnacharya G.; Tetrahedron Letters; vol. 52; 38; (2011); p. 4950 – 4953;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

34801-09-7, These common heterocyclic compound, 34801-09-7, name is N-(2-Aminophenyl)acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1.00 g (5.2 mmol) of compound 1a and 0.78 g (5.2 mmol) of N-(2-amino-phenyl)acetamide in 10 mL of ethanol was refluxed for 1 h. The mixture was cooled and evaporated by half, and the yellow solid was filtered off. Yield 1.20 g (71%), mp 130-132C (decomp., from EtOH). IR spectrum, nu, cm -1 : 3272 (NH, OH), 1715 (C=O). 1 H NMR spectrum, delta, ppm: 2.11 s (3H, Me), 6.38 s (1H, 3-H), 7.07 m (1H, H arom ), 7.17 m (2H, H arom ), 7.32 m (1H, H arom ), 7.49-7.60 m (3H, H arom ), 7.96 m (2H, H arom ), 9.82 s (1H, NH), 11.61 s (1H, NH). 13 C NMR spectrum, delta C , ppm: 22.8 (Me), 95.3 (C 3 ); 122.6, 125.1, 125.9, 127.1, 128.2, 128.5, 128.9, 130.3, 131.9, 138.5 (C arom ); 151.9 (C 2 ), 165.2 (COOH), 168.8 (CONH), 189.3 (COPh). Mass spectrum: m/z 325.15 [M + H] + . Found, %: C 66.59; H 4.87; N 8.44. C 18 H 16 N 2 O 4 . Calculated, %: C 66.66; H 4.97; N 8.64. [M + H] + 325.12

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 34801-09-7.

Reference:
Article; Stepanova; Dmitriev; Maslivets; Russian Journal of Organic Chemistry; vol. 55; 3; (2019); p. 402 – 405; Zh. Org. Khim.; vol. 55; 3; (2019); p. 469 – 473,5;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

34801-09-7, A common compound: 34801-09-7, name is N-(2-Aminophenyl)acetamide, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

General procedure: added 4-dimethylaminopyridine (DMAP) to compound 9 of anhydrous tetrahydrofuransolution, stirring at room temperature for 30 min. Then added N-(3-dimethylaminopropyl)-N’-ethylcarbodiimidehydrochloride (EDCI?HCl) was to the reaction mixture and continued stirring 0.5-1h. Phenylenediamine derivatives were added to the reaction mixture, continued stirringat room temperature under nitrogen until the disappearance of the startingmaterial 9 (TLC monitoring). Afterevaporation of the solvent, residue was diluted in CH2Cl2and washed with saturated NaHCO3, water and saturated NaCl. Theorganic layer was dried over Na2SO4, filtrated, and evaporatedthe solvent in vacuo. The resulting residue was purified by silica gelchromatography to yield the corresponding product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(2-Aminophenyl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Song, Jiao; Peng, Peng; Chang, Jun; Liu, Ming-Ming; Yu, Jian-Ming; Zhou, Lu; Sun, Xun; Bioorganic and Medicinal Chemistry Letters; vol. 26; 9; (2016); p. 2174 – 2178;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics