Category: 34489-85-5

CuI/L-proline-catalyzed intramolecular aryl amination: an efficient route for the synthesis of 1,4-benzodiazepinones was written by Majumdar, K. C.;Ganai, Sintu. And the article was included in Synlett in 2011.Electric Literature of C13H11BrN2O The following contents are mentioned in the article:

An effective protocol for the synthesis of potentially bioactive benzo[e]chromeno[6,5-b][1,4]diazepine-3,8(7H,13H)-dione and dibenzo[b,e][1,4]diazepin-11(10H)-one derivatives in good to excellent yields has been achieved by CuI/L-Proline catalyzed coupling reaction as the key step. The methodol. offers clean reaction conditions and easy isolation of the products in 61-92% yields. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Electric Literature of C13H11BrN2O).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C13H11BrN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

NaNO₂/I₂ as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides was written by Barak, Dinesh S.;Mukhopadhyay, Sushobhan;Dahatonde, Dipak J.;Batra, Sanjay. And the article was included in Tetrahedron Letters in 2019.COA of Formula: C13H11BrN2O The following contents are mentioned in the article:

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO₂) and Iodine (I₂) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramol. cyclization. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5COA of Formula: C13H11BrN2O).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.COA of Formula: C13H11BrN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Deep eutectic solvent mediated synthesis of quinazolinones and dihydroquinazolinones: synthesis of natural products and drugs was written by Ghosh, Suman Kr;Nagarajan, Rajagopal. And the article was included in RSC Advances in 2016.Application of 34489-85-5 The following contents are mentioned in the article:

A mild and greener protocol was developed to synthesize substituted quinazolinones and dihydroquinazolinones via deep eutectic solvent (DES) mediated cyclization with a series of aliphatic, aromatic, and heteroaromatic aldehydes in good to excellent yields. This greener strategy was further utilized to synthesize various quinazolinone natural products and drugs. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Application of 34489-85-5).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application of 34489-85-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Potassium carbonate mediated unusual transformation of 2,3-dihydroquinazolinone via cascade reaction was written by Sharma, Moni;Mahar, Rohit;Shukla, Sanjeev K.;Kant, Ruchir;Chauhan, Prem M. S.. And the article was included in Tetrahedron Letters in 2013.Recommanded Product: 34489-85-5 The following contents are mentioned in the article:

An unusual potassium carbonate mediated transformation of 2,3-dihydroquinazolinone by a one-pot operation is reported under mild conditions. In addition, it is interesting to report the regioselective transformation of 3-(2-bromophenyl)-2-isopropyl-2,3-dihydroquinazolin-4(1H)-one I from compound II. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Recommanded Product: 34489-85-5).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 34489-85-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Structurally diversified synthesis of 2,3-dihydroquinazolin-4-(1H)-ones from 2-aminobenzamides and 1,2-dicarbonyl compounds in ionic liquids catalyzed by iodine was written by Wang, Jie;Zhang, Mei-Mei;Wang, Xiang-Shan. And the article was included in Research on Chemical Intermediates in 2017.Recommanded Product: 34489-85-5 The following contents are mentioned in the article:

A green procedure for the rapid diversification of quinazolin-4-(1H)-one scaffolds is described in this paper. Various types of 1,2-dicarbonyl compounds are treated with 2-aminobenzamides in ionic liquids catalyzed by iodine and unexpectedly afford structurally diversified single-quinazoline derivatives The recyclability of the ionic liquids makes this protocol to be an environmentally benign procedure. A total of 39 quinazolin-4-(1H)-one scaffolds were synthesized via a green procedure of 1,2-dicarbonyl compounds and 2-aminobenzamides in ionic liquids catalyzed by iodine. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Recommanded Product: 34489-85-5).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 34489-85-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and antimicrobial activity of 1,2-diaryl- and 2,3-diaryl-(2-aryl-3-n-arylamino)-1,2,3,4-tetrahydroquinazolin-4-ones was written by Sattarova, O. E.;Vizgunova, O. L.;Voronina, E. V.. And the article was included in Pharmaceutical Chemistry Journal in 2006.Safety of 2-Amino-N-(2-bromophenyl)benzamide The following contents are mentioned in the article:

A series of 2,3-diaryl, (2-aryl-3-N-arylamino)- and 1,2-diaryl-1,2,3,4-tetrahydroquinazolin-4-ones, e.g., I (R = Br or NO₂) were obtained via reactions of arylamides and anthranilic acid phenylhydrazide or N-arylanthranilic acid amides with 5-bromo- or 5-nitrosalicylic aldehydes. One of these compounds was acetylated to obtain a triacetyl derivative The structures of the synthesized compounds were determined by spectral methods (¹H NMR, IR) and their antimicrobial activity was evaluated. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Safety of 2-Amino-N-(2-bromophenyl)benzamide).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Safety of 2-Amino-N-(2-bromophenyl)benzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Boron tribromide catalysed facile and efficient synthesis of 2,3-disubstituted Quinazolinone derivatives was written by Jaganmohan, Chikkanti;Rao, Vinti S. P.;Shiva Prakash, P.;Vinay Kumar, K. P.;Mohanty, Sandeep;Kumar, Jaydeep;Venkateswara Rao, B.;Raghunadh, Akula. And the article was included in Heterocyclic Letters in 2019.Recommanded Product: 34489-85-5 The following contents are mentioned in the article:

A simple, convenient synthetic protocols have been developed for the synthesis of 2,3-disubstituted quinazolinone derivatives I (R = Me, Ph, 4-methoxyphenyl, etc.) using borontribromide as efficient catalyst. This reaction proceeds under mild conditions. This method was found to be better method giving high yields. The present method shows some advantages such as short reaction times and enhanced selectivity. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Recommanded Product: 34489-85-5).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 34489-85-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Palladium-catalysed regioselective N-arylation of anthranilamides: a tandem route for dibenzodiazepinone synthesis was written by Laha, Joydev K.;Manral, Neelam;Hunjan, Mandeep Kaur. And the article was included in New Journal of Chemistry in 2019.Product Details of 34489-85-5 The following contents are mentioned in the article:

A palladium-catalyzed domino approach to the synthesis of 10,11-dihydro-5H-dibenzo[b,e][1,4]diazepinones from 2-aminobenzamides and 1,2-dihaloarenes was developed. Our strategy integrating double N-arylations (inter- and intra-mol.) of 2-aminobenzamides with 1,2-dihaloarenes under palladium-catalyzed conditions is clearly distinct from the current literature available for the synthesis of dibenzodiazepinones. Unlike a previous report described for regioselective N-arylation of 2-aminobenzamide at the amine group, our mechanistic studies support the regioselective N-arylation of 2-aminobenzamide occurring first primarily at the amide group. The translational application of our protocol may be demonstrated in the synthesis of a marketed drug, clozapine. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Product Details of 34489-85-5).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 34489-85-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Metal-free C-H methylation and acetylation of heteroarenes with PEG-400 was written by Kudale, Vishal Suresh;Wang, Jeh-Jeng. And the article was included in Green Chemistry in 2020.Electric Literature of C13H11BrN2O The following contents are mentioned in the article:

A novel and an efficient route for synthesis of methyl-arylquinazolinones I [R = H, 8-Me, 7-Cl; R¹ = Ph, 4-MeOC₆H₄, 2-ClC₆H₄, etc.] and acetylated heteroarenes II [Ar = 2-quinolyl, 3-CN-2-pyridyl, 1,3-benzothiazol-2-yl, etc.] via methylation and acetylation of aza-heteroarenes using PEG-400 under O₂ and TsOH·H₂O for the first time by tuning the reaction conditions using a different set of starting materials was described. The key features of current protocol were oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance and a broad substrate scope. The potential applicability of designed methodol. was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug mols. by a one-pot strategy. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Electric Literature of C13H11BrN2O).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Electric Literature of C13H11BrN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The ultraviolet and visible absorption spectra of ortho-substituted anilines. IV. o-Amino- and o-acylamino-benzoylarylamines was written by Grammaticakis, Panos. And the article was included in Bulletin de la Societe Chimique de France in 1962.Computed Properties of C13H11BrN2O The following contents are mentioned in the article:

cf. CA 55, 22222a. The spectra of 4 types of ortho-substituted benzamides were measured and the effects of structural differences noted. The substituted benzamides have the general formula o-RNHC₆H₄CON(R’)C₆H₄X (I) where R = H, Ac, Bz, or CONHPh; R’ = H or Me; X = H, Me, Cl, Br, or OMe, also where C₆H₄X = 2,6-Me₂C₆H₃ or 2,4,6-Me₃C₆H₂. The compounds were dissolved in 95% EtOH and 20 figures show the spectra log ε, 2142-3750 A., of 60 compounds Preparation methods are discussed and m.ps. are reported for the following, with X as noted. I, R = R’ = H H 119°, o-Ph 1120, o-Me 107°, o-Me 119°, m-Me 150°, o-Cl 99-100°, m-Cl 137-8°, p-Cl 148-9°, o-Br 103-4°, o-Br 151°, m-Br 156°, o-MeO 109°, m-MeO 87°, p-MeO 121°. o-Aminobenzoyl-N-methylaniline, o-aminobenzoyl-2,6-di-methylaniline, o-aminobenzoyl-2,4,6-trimethylaniline m. 129°, 137, 143-4°, resp. For I, R=Ac, R’=H: H 166°, o-Ph 166°, o-Me 163°, m-Me 178°, o-Me 193°, o-Cl 152-3°, m-Cl 189°, p-Cl 204°, o-Br 156°, m-Br 194°, m-Br 207°, o-MeO 139°, m-MeO 170°, m-MeO 189°. o-Acetamido-benzoyl-N-methylaniline, o-acetamidobenzoyl-2,6-dimeth-ylaniline, o-acetamidobenzoyl-2,4,6-trimethylaniline m. 128°, 180°, 207°, resp. I, R = Bz, R’ = H: H 280°, o-Ph 180°, o-Me 220-1% m-Me 224°, o-Me 233°, o-Cl 173°, m-Cl 244°, p-Cl 250°, o-Br 171°, o-MeO 166°, o-MeO 198°, p-OMe 233°. o-Benzamidobenzoyl-N-methylaniline, o-benzamidobenzoyl-2,6-dimethylaniline, o-benzamidoben-zoyl-2,4,6-trimethylaniline m. 134°, 207-8°, 228-9°, resp. I, R = CONHPh, R’ = H: H 250°, o-Ph 224°, o-Me 265°, m-Me 217°, o-Me 232°, o-Cl 223°, p-Cl 243°, o-MoO 205°, m-MoO 231°, m-MeO 215°, o-Phenylcarbamoylbenzoyl-N-methylaniline, o-phenylcarbamoyl-2,4,6-trimethylaniline m. 156-7°, 240°, resp. Higher m.ps. are recorded with the Maquenne block. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Computed Properties of C13H11BrN2O).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C13H11BrN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics