Ghidu, Victor P. published the artcileA new and efficient synthetic route for the anxiolytic agent CL285032, Synthetic Route of 325715-13-7, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(1), 259-261, database is CAplus and MEDLINE.
CL285032, i.e. 6-[3-(acetylmethylamino)phenyl]-3-methyl[1,2,4]triazolo[4,3-b]pyridazine, is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires 7 steps and has a low overall yield (18%), leaving opportunity for improvement. The authors present an efficient alternative approach toward the synthesis of CL285032 from 3-AcMeNC6H4Ac over 3 steps with 65% overall yield.
Bioorganic & Medicinal Chemistry Letters published new progress about 325715-13-7. 325715-13-7 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Ketone,Amide, name is N-(3-Acetylphenyl)-N-methylacetamide, and the molecular formula is C11H13NO2, Synthetic Route of 325715-13-7.
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