Category: 3119-02-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3119-02-6, name is 4-Cyanobenzenesulphonamide, A new synthetic method of this compound is introduced below., SDS of cas: 3119-02-6

General procedure: Note that compounds 18a to 18e are similar to compounds 6a to 6g described in examples above. Consequently they were synthesized using similar procedures to Example 7, above. Their synthesis is also indicated in FIG. 4 as reaction ?b?. To a round-bottom flask equipped with a stir bar was added 17a-e(1.0 eq) (prepared using similar procedures as described in Examples 2-5), hydroxylamine hydrochloride (2.0 eq), NaHCO3 (4.0 eq), and methanol (5.0 mL/mmol). The reaction was refluxed and stirred in a pre-heated 75 C. oil-bath for 6 h. The reaction mixture was cooled to room temperature, and the precipitate was filtered off and washed with methanol. The filtrate was concentrated in vacuo without further purification. Example 58 Synthesis of 151 (E)-N?-hydroxy-4-sulfamoylbenzimidamide (18a) (0215) The synthesis follows the general procedure described in Example 57. Yield: 70%. MP: 217-219 C. 1H NMR (400 MHz, DMSO-d6) delta =7.88-7.78 (m, 4H, -ArH), 5.93 (s, 2H, -SO2NH2).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Washington University; Tu, Zhude; Rosenberg, Adam; Liu, Hui; Han, Junbin; US2019/2450; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

3119-02-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3119-02-6, name is 4-Cyanobenzenesulphonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 4-cyano benzenesulfonamide (3.8 g, 20.88 mmol, Intermediate 42 or commercial source: Combi-Blocks) in Lambda/,/V-dimethylformamide (50 mL), sodium azide (13.57 g, 208.73 mmol) and ammonium chloride (1 1.17 g, 208.78 mmol) were added at 27 C. The reaction mixture was heated to 120 C and was stirred at the same temperature for 5 h. Upon completion, the reaction mixture was cooled to 27 C, quenched with 1 N HCI (150 mL) and extracted with ethyl acetate (3×100 mL). The organic layer was dried over anhydrous Na2S04, filtered and the filtrate was concentrated under reduced pressure. The residue was stirred with dichloromethane (10 mL) at 27 C for 30 min and filtered. The solid was dried under vacuum to afford 4-(2H-tetrazol-5- yl)benzenesulfonamide (3.2 g, 68%) as an off-white solid.1H NMR (400 MHz, DMSO-c/6) delta 8.23 (d, J = 8.5 Hz, 2H), 8.04 (d, J = 8.5 Hz, 2H), 7.53 (s, 2H). MS m/z [M-H]”=224.03.

The synthetic route of 4-Cyanobenzenesulphonamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

3119-02-6, Adding some certain compound to certain chemical reactions, such as: 3119-02-6, name is 4-Cyanobenzenesulphonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3119-02-6.

General procedure: To a stirred suspension of nitrile (30 mmol) and hydroxylaminehydrochloride (3.13 g, 45 mmol) in EtOH (50 mL) a NaHCO3 (3.78 g,45 mmol)was added. The reaction mixturewas stirred under refluxfor 6 h. After the reaction had completed, the reaction mixture wasconcentrated under reduced pressure, and the residue was dilutedwith cold water (80 mL). The resulting precipitate was filtered off,washed with cold water (20 mL) and dried in air at roomtemperature.4.2.3. N’-Hydroxypicolinimidamide (10a) [35]Yield 3.54 g (86%); White solid; m.p. 117-118 C. 1H NMR(400 MHz, DMSO) delta ppm 9.90 (s, 1H), 8.57 (d, J 4.8 Hz, 1H), 7.86 (d,J 7.9 Hz, 1H), 7.82 (t, J 8.1 Hz, 1H), 7.40 (t, J 6.6 Hz, 1H), 5.80(br.s, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3119-02-6.

Reference:
Article; Krasavin, Mikhail; Shetnev, Anton; Sharonova, Tatyana; Baykov, Sergey; Kalinin, Stanislav; Nocentini, Alessio; Sharoyko, Vladimir; Poli, Giulio; Tuccinardi, Tiziano; Presnukhina, Sofia; Tennikova, Tatiana B.; Supuran, Claudiu T.; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 92 – 105;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics