Category: 3118-68-1

Application of 3118-68-1, These common heterocyclic compound, 3118-68-1, name is 3-Cyanobenzenesulfonamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The intermediate from step A above (722 mg), di-tert-butyl dicarbonate (1.6 g) and nickel(II) chloride hexahydrate (80 mg) was dissolved in dry methanol (20 mL) and cooled to 0 C. Then sodium borohydride (1.0 g) was added in portions and the ice bath removed. The mixture was vigorously stirred for 2 h, then diethylenetriamine (300 muL) was added and the mixture was concentrated to dryness. The residue was diluted with ethyl acetate, washed with 10% citric acid, saturated sodium hydrogen carbonate and brine, dried (MgSO4) and concentrated. Purification by column chromatography (dichloromethane/methanol, 96:4 to 95:5) gave a amorphous mass, which was suspended in hydrogen chloride (4M solution in dioxane, 15 mL) and stirred for 6 h, evaporated, slurried in diethyl ether and filtered to afford the title compound (590 mg; 67%). [M-Cl]+=187.

The synthetic route of 3118-68-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Alantos Pharmaceuticals, Inc.,; US2006/173183; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3118-68-1, name is 3-Cyanobenzenesulfonamide, A new synthetic method of this compound is introduced below., category: amides-buliding-blocks

Production Example 27 N-hydroxy-3-sulfamoylbenzene carboximidamide A mixture of 3-cyanobenzenesulfonamide (5.00 g), 50% hydroxylamine aqueous solution (1.84 mL) and ethanol (27 mL) was heated to reflux for 6 hours. Thereafter, the reaction solution was concentrated under a reduced pressure, so as to obtain the title compound (5.80 g) in the form of a colorless amorphous substance. 1H NMR (600 MHz, DMSO-d6) delta ppm 5.92 (s, 2H) 7.36 (s, 2H) 7.57 (t, J=7.79 Hz, 1H) 7.72-7.93 (m, 2H) 8.09-8.21 (m, 1H) 9.80 (s, 1H); MS (ESI neg.) m/z: 214 [M-H]-

The synthetic route of 3118-68-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; Nakamura, Toshio; Sakagami, Kazunari; Konishi, Kazuhide; Yamamoto, Kanako; Masuda, Seiji; Matsuda, Yohei; Okada, Kumiko; Shibata, Tsuyoshi; Ohta, Hiroshi; Yasuhara, Akito; Kawamoto, Hiroshi; Amada, Hideaki; Urabe, Hiroki; Nishikawa, Rie; Kashiwa ASHIWA, Shuhei; US2013/137865; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics