Category: 29038

Patel, Harsh; Vyas, Piyush; Nishant, Yadav; Nayanaben, Parmar published an article in 2022, the title of the article was Synthesis, characterization and antimicrobial activity of novel pyrimido-triazine fused heterocyclic compounds.Reference of 2-Chloroacetamide And the article contains the following content:

Condensation of aminopyrimidinethione I (R = H) with chloroacetamide afforded the corresponding acetamide I (R = H2NCOCH2) which further cyclized under basic conditions to give pyrimido[1,2-b][1,2,4]triazin-3(2H)-one II (X = H2) containing an active methylene group. The latter reacted with diazonium salts of various sulfa drugs to afford the hydrazones II [X = 4-RSO2C6H4NHN; R = H2N, (H2N)2C:N, 2-pyrimidinylamino, 2,6-dimethoxypyrimidin-4-ylamino, 5-methylisoxazol-3-ylamino, etc.]. These compounds were screened for their in vitro antibacterial activity against Gram pos. bacteria (Bacillus Subtilis, Staphylococcus aureus), Gram-neg. bacteria (Klebsiella promioe, E. coli) and antifungal activity against plant pathogens (Botryodiplodia theobromae, Nigrospora Sp., Penicillium Expansum, Rhizopus Nigricans). The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Reference of 2-Chloroacetamide

The Article related to pyrimidotriazine furyl hydrazone sulfonamide antibacterial antifungal, Placeholder for records without volume info and other aspects.Reference of 2-Chloroacetamide

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On February 28, 2021, Chikineva, T. Yu.; Koshelev, D. S.; Medved鈥瞜o, A. V.; Vashchenko, A. A.; Lepnev, L. S.; Goloveshkin, A. S.; Utochnikova, V. V. published an article.Category: amides-buliding-blocks The title of the article was Ytterbium and Europium Complexes with Naphtho[1,2]thiazole-2-carboxylic and Naphtho[2,1]thiazole-2-carboxylic Acid Anions for Organic Light-Emitting Diodes (OLED). And the article contained the following:

An approach to the directed synthesis of aromatic lanthanide carboxylates as promising candidates for various luminescent applications, first of all, as emitting layers in light-emitting diodes, by varying the conjugation length with the introduction of a heteroatom and a neutral ligand was proposed. This approach enabled the synthesis of new europium and ytterbium complexes with naphtho[1,2]thiazole-2-carboxylic and naphtho[2,1]thiazole-2-carboxylic acid anions, which were successfully used in light-emitting diodes. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Category: amides-buliding-blocks

The Article related to naphtho thiazole carboxylic acid anion oled ytterbium europium complex, Placeholder for records without volume info and other aspects.Category: amides-buliding-blocks

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Gan, Guohong; Xu, Xiao; Chen, Xi; Zhang, Xiu-Fang; Wang, Jinling; Zhong, Chuan-Qi published an article in 2021, the title of the article was SCASP: A Simple and Robust SDS-Aided Sample Preparation Method for Proteomic Research.Safety of 2-Chloroacetamide And the article contains the following content:

SDS is widely used in sample preparation for proteomic research. However, SDS is incompatible with LC and electrospray ionization. SDS depletion is therefore required ahead of LC-MS anal. Most of current SDS removal strategies are time consuming, laborious, and have low reproducibility. Here, we describe a method, SDS-cyclodextrin (CD)-assisted sample preparation, by which CD can bind to SDS and form CD-SDS complexes in solutions, allowing for direct tryptic digestion. We demonstrate that SDS-CD-assisted sample preparation is a simple, fast, and robust SDS-based sample preparation method for proteomics application. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Safety of 2-Chloroacetamide

The Article related to scasp sds sample preparation proteomic research, sdc, sds, sample preparation, Placeholder for records without volume info and other aspects.Safety of 2-Chloroacetamide

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On August 5, 2021, Masulovic, Aleksandra D.; Ladjarevic, Jelena M.; Radovanovic, Lidija D.; Vitnik, Zeljko J.; Vitnik, Vesna D.; Rogan, Jelena R.; Mijin, Dusan Z. published an article.Application of 79-07-2 The title of the article was Charge assisted assembly of zwitterionic pyridone hydrates. And the article contained the following:

Two pyridone derivatives, bearing the pyridinium moiety (1), or dimethylpyridinium moiety (2) I and II, have been synthesized and their crystal structures have been determined The compounds crystalize in hydrated zwitterionic forms with either two (1路2H2O) or four (2路4H2O) water mols. The zwitterionic networks contain different types of water clusters, generated into channels, incorporating them into the network by sandwiching. The type of channel depends on the crystal lattice and the nature of non-covalent interactions established between zwitterions as well as the number of water mols. incorporated into the architecture. 1 affords tubes filled in with water channels formed by water tetramers, contrary to 2, which affords a layered network altering the zwitterionic layer and the layer formed by water tetramers and hexamers. A detailed study of intermol. interactions of both crystal structures and a quantification of interaction energies has been performed using PIXEL lattice energy calculations, giving an insight to a quant. evaluation of interactions through Coulombic, disperse, repulsion and polarization energies. The strongest pairwise, in both structures, is found to be a dipole-dipole interaction between oppositely charged heterocyclic rings. The differences in the crystal packings of these hydrates have been elucidated by the fingerplot anal. The comparative studies between exptl. and calculated (DFT) data of mols. 1路H2O and 2路4H2O for systems of different complexity are performed. Furthermore, correlations of exptl. and calculated bond lengths and the simulation of compound solvation with the CPCM model are done. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to crystallog charge assisted assembly zwitterionic pyridone hydrates preparation, Placeholder for records without volume info and other aspects.Application of 79-07-2

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On October 31, 2020, Kaur, Ravneet; Goyal, Dinesh published an article.Recommanded Product: 79-07-2 The title of the article was Biodegradation of Butachlor by Bacillus altitudinis and Identification of Metabolites. And the article contained the following:

Butachlor is a chloroacetamide pre-emergence herbicide, with a half-life of 1.6 to 29 days. It is a suspected carcinogen, genotoxin, neurotoxin and persists in the environment having toxic effect on living systems. Butachlor degrading bacterial strain A16 was isolated from coal tar contaminated soil, which showed 99.38% similarity with Bacillus altitudinis 41KF2bT as revealed by 16S rRNA anal. B. altitudinis strain A16 utilized butachlor as a sole source of carbon and degraded 90% of 50 mg L-1 butachlor in 5 days at a rate constant and half-life (t1/2) of 0.02 h-1 and 34.65 h, resp., following the first-order reaction kinetics. Five metabolites (N-(butoxymethyl)-N-(2-chloroethyl)-2,6-diethylaniline, (N-(butoxymethyl))-2-chloro-N-(2-ethylphenyl) acetamide, N-(butoxymethyl)-2,6-diethyl-N-propylaniline, 2-chloro-N-(2,6-diethylphenyl) acetamide and 2,6-diethylaniline) were produced during the breakdown of butachlor by B. altitudinis A16 as identified by GC-MS anal., which are further mineralized to carbon dioxide and water. A metabolic pathway is proposed and compared with other bacteria. The findings have immense beneficial application since such microbes can be used on large scale for faster soil bioremediation and minimizing neg. impact of pesticide butachlor on health and environment. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 79-07-2

The Article related to butachlor contaminated soil bacillus altitudinis metabolite herbicide biodegradation, Placeholder for records without volume info and other aspects.Recommanded Product: 79-07-2

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Amide – Wikipedia,
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On November 30, 2022, Ahmed, Ahmed A. M.; Mekky, Ahmed E. M.; Sanad, Sherif M. H. published an article.Safety of 2-Chloroacetamide The title of the article was New bis(pyrazolo[3,4-b]pyridines) and bis(thieno[2,3-b]pyridines) as potential acetylcholinesterase inhibitors: synthesis, in vitro and SwissADME prediction study. And the article contained the following:

The bis(pyridine-2(1H)-thione) was prepared and taken as a key synthon of this study. The target bis(pyrazolo[3,4-b]pyridines) was prepared in good yields, by the reaction of bis(pyridine-2(1H)-thione) with appropriate hydrazonyl chlorides to yield bis(hydrazonothioates) followed by their heating in ethanolic sodium ethoxide solution Addnl., bis(pyridine-2(1H)-thione) reacted with different 伪-halogenated reagents to afford a new series of bis(thieno[2,3-b]pyridines), in good to excellent yields. In general, the tested series of bis(thieno[2,3-b]pyridines) demonstrated greater acetylcholinesterase inhibitory activity as well as DPPH antioxidant activity than the other series of (pyrazolo[3,4-b]pyridines). At a concentration of 100 渭M, bis(thieno[2,3-b]pyridine-2-carbonitrile) showed the best acetylcholinesterase inhibitory activity with inhibition percentage of 83.2. In addition, the previous hybrid had the highest DPPH antioxidant activity, with an inhibition percentage of 82.6 when tested at a concentration of 25 渭g/mL. Furthermore, SwissADME was used to predict the physicochem. properties, lipophilicity, and drug likeness of the new products. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Safety of 2-Chloroacetamide

The Article related to pyrazolopyridine thienopyridine preparation acetylcholinesterase inhibitor antioxidant swissadme prediction, Placeholder for records without volume info and other aspects.Safety of 2-Chloroacetamide

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Belarbi, Saida; Vivier, Martin; Zaghouani, Wafa; De Sloovere, Aude; Agasse, Valerie; Cardinael, Pascal published an article in 2021, the title of the article was Comparison of Different d-SPE Sorbent Performances Based on Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) Methodology for Multiresidue Pesticide Analyses in Rapeseeds.Formula: C2H4ClNO And the article contains the following content:

Pesticide extraction in rapeseed samples remains a great anal. challenge due to the complexity of the matrix, which contains proteins, fatty acids, high amounts of triglycerides and cellulosic fibers. An HPLC-MS/MS method was developed for the quantification of 179 pesticides in rapeseeds. The performances of the quick, easy, cheap, effective, rugged, and safe (QuEChERS) method were evaluated using different dispersive solid-phase extraction (d-SPE) sorbents containing common octadecylsilane silica/primary-secondary amine adsorbent (PSA/C18) and new commercialized d-SPE materials dedicated to fatty matrixes (Z-Sep, Z-Sep+, and EMR-Lipid). The anal. performances of these different sorbents were compared according to the SANTE/12682/2019 document. The best results were obtained using EMR-Lipid in terms of pesticide average recoveries (103 and 70 of the 179 targeted pesticides exhibited recoveries within 70-120% and 30-70%, resp., with low RSD values). Moreover, the limits of quantification (LOQ) range from 1.72 渭g/kg to 6.39 渭g/kg for 173 of the pesticides. Only the recovery for tralkoxydim at 10 渭g/kg level was not satisfactory (29%). The matrix effect was evaluated and proved to be limited between -50% and 50% for 169 pesticides with this EMR-Lipid and freezing. GC-Orbitrap analyses confirmed the best efficiency of the EMR-Lipid sorbent for the purification of rapeseeds. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to rapeseed solid phase extraction sorbent pesticide hplc ms, hplc-ms/ms, quechers extraction, dispersive solid-phase extraction, multiresidue pesticide analyses, rapeseeds, Placeholder for records without volume info and other aspects.Formula: C2H4ClNO

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Amide – an overview | ScienceDirect Topics

On January 11, 2021, Wiktelius, Daniel; Allgardsson, Anders; Bergstroem, Tomas; Hoster, Norman; Akfur, Christine; Forsgren, Nina; Lejon, Christian; Hedenstroem, Mattias; Linusson, Anna; Ekstroem, Fredrik published an article.Product Details of 79-07-2 The title of the article was In Situ Assembly of Choline Acetyltransferase Ligands by a Hydrothiolation Reaction Reveals Key Determinants for Inhibitor Design. And the article contained the following:

The potential drug target choline acetyltransferase (ChAT) catalyzes the production of the neurotransmitter acetylcholine in cholinergic neurons, T-cells, and B-cells. Herein, we show that arylvinylpyridiniums (AVPs), the most widely studied class of ChAT inhibitors, act as substrate in an unusual CoA-dependent hydrothiolation reaction. This in situ synthesis yields an adduct that is the actual enzyme inhibitor. The adduct is deeply buried in the active site tunnel of ChAT and interactions with a hydrophobic pocket near the choline binding site have major implications for the mol. recognition of inhibitors. Our findings clarify the inhibition mechanism of AVPs, establish a drug modality that exploits a target-catalyzed reaction between exogenous and endogenous precursors, and provide new directions for the development of ChAT inhibitors with improved potency and bioactivity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to arylvinylpyridinium choline acetyltransferase inhibitor hydrothiolation, choline acetyltransferase, coenzyme a, drug discovery, hydrothiolation, in situ assembly, Placeholder for records without volume info and other aspects.Product Details of 79-07-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics