Category: 2896-98-2

Application of 2896-98-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2896-98-2, name is Tetrahydro-1,4-thiazepan-5-one, This compound has unique chemical properties. The synthetic route is as follows.

(Ref: J. Org. Chem. 1960, 25, 1953-1956.) To a stirred solution of 1,4- thiazepan-5-one (9.16 g, 70 mmol) in THF (271 mL) at 0 0C is added dropwise over20 min LAH (IM in THF, 70 mL, 70 mol). The reaction mixture is stirred at 0 0C for 10 min and then warmed to RT, stirring is continued for 2 h. The reaction mixture is quenched with careful successive addition of H2O (2.5 mL), 5N aqeous NaOH (2.5 mL) and H2O (9 mL). A thick gel like precipitate formed. The reaction mixture is filtered through a small pad of Celite, and the filter cake is washed with ether (300 mL). The filtrate is concentrated to afford the title compound as an oil, which is used immediately in the next reaction. 1H NMR (400 MHz, DMSO) delta 2.89 (t, 2H), 2.84 (t, 2H), 2.69 (t, 2H), 2.59 (t,2H), 1.78 (m, 2H).

The chemical industry reduces the impact on the environment during synthesis Tetrahydro-1,4-thiazepan-5-one. I believe this compound will play a more active role in future production and life.

Reference:
Patent; PHARMACIA & UPJOHN COMPANY LLC; WO2006/56875; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2896-98-2, name is Tetrahydro-1,4-thiazepan-5-one, A new synthetic method of this compound is introduced below., SDS of cas: 2896-98-2

To a solution of 1,4-thiazepan-5-one (3.0 g) in distilled THF (90 mL) cooled to 0 C. is added dropwise a solution of LiAlH4 in THF (1M solution, 22.9 mL). The mixture is stirred at room temperature for 2 h. The reaction is quenched by successive addition of water (2 mL), 15% NaOH (2 mL) and water (2 mL). The reaction mixture is filtered to remove the aluminum salt that had precipitated. The filtrate was dried (Na2SO4), filtered, and concentrated to obtain 2.63 g (98%) of 1,4-thiazepane as a yellow residue. Physical characteristics are as follows: 1H NMR (300 MHz, CDCl3) delta3.07, 2.96, 2.75, 1.92.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Pharmacia & Upjohn Company; US6248739; (2001); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics