Category: 2835-68-9

Application of 2835-68-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2835-68-9 name is 4-Aminobenzamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-aminobenzamide (5.0 g, 36.7 mmol) and pyridine (2.9 g, 36.7 mmol)) in dry CH2Cl2 (100 mL) at -10 C., phenyl chloroformate (6.9 g, 44.1 mmol) was added dropwise, stirred at -10 C. for 30 min and then at room temperature for 30 minutes The reaction mixture was diluted with CH2Cl2 (100 mL) and washed with water (2×70 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated to get the crude product. The crude product was dissolved in diethyl ether (15 mL) and sonicated for 10 minutes and then pentane (30 mL) was added, the resulting solid was filtered and washed with pentane to give phenyl 4-carbamoylphenylcarbamate (7.2 g, 77% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Aminobenzamide, and friends who are interested can also refer to it.

Reference:
Patent; WYETH LLC; VENKATESAN, Aranapakam Mudumbai; CHEN, Zecheng; DEHNHARDT, Christoph Martin; DOS SANTOS, Osvaldo; DELOS SANTOS, Efren Guillermo; ZASK, Arie; VERHEIJEN, Jeroen Cunera; KAPLAN, Joshua Aaron; RICHARD, David James; AYRAL-KALOUSTIAN, Semiramis; MANSOUR, Tarek Suhayl; GOPALSAMY, Ariamala; CURRAN, Kevin Joseph; SHI, Mengxiao; (113 pag.)US2017/119778; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 2835-68-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2835-68-9, name is 4-Aminobenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a mixture of 3-chloro-5-[(3-hydroxy-4-methylphenyl)amino]-4H-1,2,6-thiadiazin-4-one (7) (53.9 mg, 0.200 mmol), Pd[3,5-(F3C)2C6H3]3 (5.3 mg, 1.25 mol %), DPEPhos (5.3 mg, 5 mol %), powdered dry K2CO3 (66.4 mg, 0.480 mmol) and 3-aminobenzamide (30.0 mg, 0.220 mmol) was added dioxane (5 mL). The stirred suspension was then deaerated by bubbling of Ar through it for 5 min and then heated at reflux under Ar until complete consumption of the starting thiadiazine (TLC, 2 h). The mixture was cooled to ca. 20 C, then adsorbed onto silica and chromatographed (n-hexane/acetone, 50:50) to give the title compound 1 (63.1 mg, 85%) as orange needles, m.p. 297-298 C (from THF)

The synthetic route of 4-Aminobenzamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Asquith, Christopher R. M.; Godoi, Paulo H.; Cou ago, Rafael M.; Laitinen, Tuomo; Scott, John W.; Langendorf, Christopher G.; Oakhill, Jonathan S.; Drewry, David H.; Zuercher, William J.; Koutentis, Panayiotis A.; Willson, Timothy M.; Kalogirou, Andreas S.; Molecules; vol. 23; 5; (2018);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2835-68-9, name is 4-Aminobenzamide, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Aminobenzamide

General procedure: A solution of 3a-e (2 mmol) in10 mL THF was added slowly to a cooled solution of 4,6-dichloro-5-nitropyrimidine (0.43 g, 2.2 mmol) and TEA (0.20 g, 2 mmol) in THF (20 mL), and mixture was stirred for about 30 min at 0 C. Stirring was continued for 4 h at room temperature and the reaction was monitored by TLC. The reaction mixture was added into 60 mL H2O, and extracted with EA (50 mL ¡Á 2). The combined organic extract was washed with brine, dried over anhydrous Na2SO4, and concentrated in vacuo to get the crude product which was next purified by column chromatography on silica employing ethyl acetate/petroleum ether as eluted to obtain the pure product to give the product 3a-e.

The synthetic route of 2835-68-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yu, Xu-Ri; Tang, Yun; Wang, Wen-Jing; Ji, Sen; Ma, Shuang; Zhong, Lei; Zhang, Chun-Hui; Yang, Jiao; Wu, Xiao-Ai; Fu, Zheng-Yan; Li, Lin-Li; Yang, Sheng-Yong; Bioorganic and Medicinal Chemistry Letters; vol. 25; 22; (2015); p. 5449 – 5453;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 2835-68-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2835-68-9 name is 4-Aminobenzamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of amine (1 mmol) in water (2 ml) was added tetrahydro-2,5-dimethoxyfuran (1.1 mmol) and gamma-Fe2O3(at)SiO2-Sb-IL (0.08 g). The reaction mixture was stirred at 100 C for a certain period of time as required to complete the reaction. During that time, the reaction was monitored constantly by TLC. After completion of the reaction, the catalyst was removed by using a magnet and washed with ethyl acetate. The aqueous solution was extracted by ethyl acetate (3 ¡Á 5 ml). The combined organic phase was dehydrated with anhydrous sodium sulfate. After the evaporation of the solvent, the residue was purified by silica gel flash chromatography using petroleum ether/ethyl acetate as the eluent to afford the pure product. 4-(1H-Pyrrol-1-yl)benzamide (3an). IR (KBr): 3142, 1645, 1613, 1577, 1525, 1475, 1425, 1394, 1327, 1199, 1120, 1064, 1014, 920, 846, 723 cm-1; 1H NMR (CDCl3, 500 MHz) delta: 6.39 (t, J = 2.0 Hz, 2H), 7.16 (t, J = 2.0 Hz, 2H), 7.47(d, J = 8.5 Hz, 2H), 7.89 (d, J = 8.5 Hz, 2H) ppm; 13C NMR (CDCl3, 125 MHz) delta: 111.4, 119.1, 119.7, 130.0, 129.1,143.4, 168.2 ppm; ESI-MS: m/z = 187 (M + 1)+; Anal. Calcd. for C11H10N2O: C, 70.95; H, 5.41; N, 15.04. Found: C, 71.12; H, 5.60; N, 14.86.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Aminobenzamide, and friends who are interested can also refer to it.

Reference:
Article; Ma, Fei-Ping; Li, Pei-He; Li, Bao-Le; Mo, Li-Ping; Liu, Ning; Kang, Hui-Jun; Liu, Ya-Nan; Zhang, Zhan-Hui; Applied Catalysis A: General; vol. 457; (2013); p. 34 – 41;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2835-68-9, name is 4-Aminobenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H8N2O

General procedure: To a 25 mL Schlenk tube containing a solution of 2 in 2 mL of THF was added amide (1.0 mmol) and (EtO)3SiH (0.50 g, 3.0 mmol). The reaction mixture was stirred at 60 C until there was no amide left (monitored by TLC and GC-MS). The product was purified according to literature procedures by Beller

The synthetic route of 2835-68-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ren, Shishuai; Wang, Yangyang; Yang, Fei; Sun, Hongjian; Li, Xiaoyan; Catalysis Communications; vol. 120; (2019); p. 72 – 75;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics