Category: 2832-19-1

Some common heterocyclic compound, 2832-19-1, name is 2-Chloro-N-(hydroxymethyl)acetamide, molecular formula is C3H6ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2832-19-1

Cresol was reacted with a-bromoisobutyric acid in the presence of NaOH to give acid 1, which was then amidomethylated using N-hydroxymethyl chloroacetamide inHOAc/H2SO4 to afford acid-amide 2. The amide was alcoholyzed in ethanol using HCI gas with concomitant ester formation to give the desired product Intermediate f. Intermediate f and Intermediate e were coupled together to form a compound of Example 1 in a manner similar to that described for the alternative route to Example 1 above.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2832-19-1, its application will become more common.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/49578; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2832-19-1, name is 2-Chloro-N-(hydroxymethyl)acetamide, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Chloro-N-(hydroxymethyl)acetamide

(e) 2-chloro-N-[5-(1,1-dimethylethyl)-2-hydroxy-3-methylsulfonylbenzyl]acetamide 13.5 g (0.06 mol) of 4-(1,1-dimethylethyl)-2-methylsulfonylphenol are dissolved in 100 ml of concentrated sulfuric acid. 6.63 g (0.054 mol) of 2-chloro-N-hydroxymethylacetamide are added and the mixture is stirred at room temperature for 10 minutes. It is then poured onto ice-water and the crude product is filtered off with suction and recrystallized from toluene. Colorless crystals of melting point: 134-135 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Hoechst Aktiengesellschaft; US4661636; (1987); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2832-19-1, name is 2-Chloro-N-(hydroxymethyl)acetamide, A new synthetic method of this compound is introduced below., COA of Formula: C3H6ClNO2

EXAMPLE 19 [2-(AMINOMETHYL)-3, 5-DI-TERT-BUTYLPHENOL HYDROCHLORIDE] Step A: [2-CHLORO-N-(2, 4-DI-TEYT-BUTYL-6-HYDROXYBENZYL)] acetamide A finely powdered mixture of 5.2 g (25 mmol) of 3, 5-di-tert- butylphenol and 3.15 g (25 mmol) [OF N-HYDROXYMETHYL-2-CHLOROACETAMIDE] was added in portions to a vigorously stirred solution of 22.5 mL acetic acid and 2.5 mL (98%) sulfuric acid at [0-10C.] The reaction mixture was allowed to warm to room temperature over several hours, and stirring was maintained for a total of 16 hours. The reaction mixture was poured into ice-water, neutralized with saturated aqueous [NAHCO3] solution and extracted into CH2C12. The organic extracts were combined, washed with brine, dried [(NA2SO4),] filtered and evaporated. The residue was purified on a silica gel flash chromatography column eluted with 15-30-50% EtOAc in hexane. Evaporation of the purified fractions and [DRYING’IN VACUO] afforded the title compound.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK & CO., INC.; WO2004/783; (2003); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2832-19-1, name is 2-Chloro-N-(hydroxymethyl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Chloro-N-(hydroxymethyl)acetamide

The starting material was prepared as follows: 2-Chloro-N-(hydroxymethyl)-acetamide (0.342 g; 2.7 mmol), triphenylphosphine (1.1 g; 4.19 mmol) and DEAD (0.6 ml; 4.19 mmol) were added to a solution of N-acetyl-colchicinol (0.3 g; 0.84 mmol) in dichloromethane (20 ml) under argon atmosphere. The mixture was stirred at ambient temperature for 2 hours, evaporated and purified by flash chromatography eluding with ethyl acetate/dichloromethane (50/50) and dichloromethane/methanol (98/2) to give (1). Yield: 76 % MS-ESI: 485.1 [MH]+

The synthetic route of 2832-19-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Angiogene Pharmaceuticals Ltd; EP1140745; (2003); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2832-19-1, name is 2-Chloro-N-(hydroxymethyl)acetamide, This compound has unique chemical properties. The synthetic route is as follows., 2832-19-1

(d) 2-Nicotinyl-4-tert-butyl-6-(N-alpha-chloroacetoaminomethyl)phenol 450 mg of the compound obtained in Example 3 (c) above was dissolved in 2 ml of a mixed solvent of acetic acid: sulfuric acid (1:1 by volume), and 330 mg of N-hydroxymethyl alpha-chloroacetamide was added to the solution. The mixture was then stirred at 60 C. for 2 hours and at 80 C. for 1 hour and poured into water. The mixture was extracted with ethyl acetate, and the ethyl acetate layer was washed successively with water and an aqueous sodium chloride solution, dried and concentrated. The residue was chromatographed on silica gel column using a mixed solvent of methylene chloride: ethyl acetate (5:1 by volume) to obtain 390 mg of the title compound having the following physical properties. TLC (methylene chloride: ethyl acetate=1:2): Rf=0.30. IR (chloroform solution): nu=3430, 2960, 1670, 1630, 1590, 1530, 1460, 1415, 1370, 1345, 1275, 1250, 1130, 1100, 1055, 1020, 995 cm-1. NMR (CDCl3 solution): delta=12.10 (1H, s), 8.47-8.85 (2H, m), 7.70-8.00 (1H, m), 7.10-7.60 (4H, m), 4.48 (2H, d, J=6 Hz), 3.98 (2H, s), 1.23 (9H, s). MS: m/e=360 (M+).

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Reference:
Patent; Ono Pharmaceutical Co., Ltd.; US4245099; (1981); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics