Category: 2736-23-4

Application of 2736-23-4,Some common heterocyclic compound, 2736-23-4, name is 2,4-Dichloro-5-sulfamoylbenzoic acid, molecular formula is C7H5Cl2NO4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The mixture of appropriate 2,4-dichloro-5-sulfamoylbenzoic acid (compound 1) or 2,4- dibromo-5-sulfamoylbenzoic acid (compound 2) (10.0 mmol), SOQ2 (2-3 eq), and 1 drop DMF in toluene (5 ml) was refluxed for 4 h. Excess SOCb and toluene were removed by distillation under reduced pressure, and the crude acid chloride was used directly in the next step.

The synthetic route of 2736-23-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VILNIUS UNIVERSITY; MATULIS, Daumantas; ?APKAUSKAIT?, Edita; ZAK?AUSKAS, Andrius; MORK?NAIT?, Vaida; (82 pag.)WO2017/17505; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 2736-23-4, name is 2,4-Dichloro-5-sulfamoylbenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 2736-23-4

SOCl2 (2.0 ml 28 mmol) was added dropwiseto a solution of 2,4-dichloro-5-sulfamoyl-benzoic acid 3 (1.50 g5.56 mmol) in DMF (4.3 ml) at 10 C. The reaction mixture wasstirred at room temperature for 2 h and then poured on ice; theresulted precipitate was filtered off and washed with water untilpH 7 was reached. Yield 77%, mp 254-255 C. 1H NMR d ppm:2.94 (3H, s, CH3N), 3.19 (3H, s, CH3N), 7.92 (1H, s,C3-H), 8.27 (1H,s,NC-H), 8.41 (1H, s,C6-H). 13C NMR d ppm: 35.8, 41.5, 130.2,132.1, 133.9, 134.6, 136.9, 139.1, 161.3, 165.2. HRMS calcd. for C10-H10Cl2N2O4S [(M+H)+]: 324.9811, found: 324.9814.

The synthetic route of 2,4-Dichloro-5-sulfamoylbenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; ?apkauskait?, Edita; Zak?auskas, Audrius; Ruibys, Virginijus; Linkuvien?, Vaida; Paketuryt?, Vaida; Gedgaudas, Marius; Kairys, Visvaldas; Matulis, Daumantas; Bioorganic and Medicinal Chemistry; vol. 26; 3; (2018); p. 675 – 687;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics