Category: 27115-50-0

On February 15, 2022, Riggs, Daniel W.; Malovichko, Marina V.; Gao, Hong; McGraw, Katlyn E.; Taylor, Breandon S.; Krivokhizhina, Tatiana; Rai, Shesh N.; Keith, Rachel J.; Bhatnagar, Aruni; Srivastava, Sanjay published an article.HPLC of Formula: 27115-50-0 The title of the article was Environmental exposure to volatile organic compounds is associated with endothelial injury. And the article contained the following:

Volatile organic compounds (VOCs) are airborne toxicants abundant in outdoor and indoor air. High levels of VOCs are also present at various Superfund and other hazardous waste sites; however, little is known about the cardiovascular effects of VOCs. We hypothesized that ambient exposure to VOCs exacerbate cardiovascular disease (CVD) risk by depleting circulating angiogenic cells (CACs). In this cross-sectional study, we recruited 603 participants with low-to-high CVD risk and measured 15 subpopulations of CACs by flow cytometry and 16 urinary metabolites of 12 VOCs by LC/MS/MS. Associations between CAC and VOC metabolite levels were examined using generalized linear models in the total sample, and sep. in non-smokers. In single pollutant models, metabolites of ethylbenzene/styrene and xylene, were neg. associated with CAC levels in both the total sample, and in non-smokers. The metabolite of acrylonitrile was neg. associated with CD45dim/CD146+/CD34+/AC133+ cells and CD45+/CD146+/AC133+, and the toluene metabolite with AC133+ cells. In anal. of non-smokers (n = 375), multipollutant models showed a neg. association with metabolites of ethylbenzene/styrene, benzene, and xylene with CD45dim/CD146+/CD34+ cells, independent of other VOC metabolite levels. Cumulative VOC risk score showed a strong neg. association with CD45dim/CD146+/CD34+ cells, suggesting that total VOC exposure has a cumulative effect on pro-angiogenic cells. We found a non-linear relationship for benzene, which showed an increase in CAC levels at low, but depletion at higher levels of exposure. Sex and race, hypertension, and diabetes significantly modified VOC associated CAC depletion. Low-level ambient exposure to VOCs is associated with CAC depletion, which could compromise endothelial repair and angiogenesis, and exacerbate CVD risk. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).HPLC of Formula: 27115-50-0

The Article related to volatile organic compound environmental exposure endothelial injury, benzene, circulating angiogenic cells, endothelial injury, ethylbenzene, vocs, volatile organic compounds and other aspects.HPLC of Formula: 27115-50-0

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Amide – an overview | ScienceDirect Topics

On May 31, 2021, Jokioja, Johanna; Percival, Jasmine; Philo, Mark; Yang, Baoru; Kroon, Paul A.; Linderborg, Kaisa M. published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was Phenolic Metabolites in the Urine and Plasma of Healthy Men After Acute Intake of Purple Potato Extract Rich in Methoxysubstituted Monoacylated Anthocyanins. And the article contained the following:

Structurally stable acylated anthocyanins have potential in various food applications but the effects of acylation and methoxysubstitution on anthocyanin metabolism are poorly understood. This is the first study thoroughly investigating phenolic metabolites, their time-wise changes, and pharmacokinetics following an acute intake of methoxysubstituted monoacylated anthocyanins. Healthy male volunteers (n = 17) consumed a yellow potato meal with and without purple potato extract rich in acylated anthocyanins (152 mg) and hydroxycinnamic acid conjugates (140 mg). Ultra-high performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) is used for identification and quantification of metabolites from serially collected urine and plasma. While the parent anthocyanins are not detected, 28 phenolic metabolites from urine and 14 from plasma are quantified, including hydroxybenzoic and hydroxycinnamic acids and protocatechuic acid sulfates and glucuronides; three (catechol, gallic acid-4-O-glucuronide, and 2-methoxybenzoic acid) are detected for the first time after anthocyanin-rich food. Urinary hippuric acid is the most abundant with an increase of 139 μM mM-1 creatinine after the treatment. A large addnl. set of tentatively identified phenolic metabolites are detected. Late urinary peak time values suggest colonic degradation Acylated anthocyanins are more bioavailable than earlier reported after extensive degradation in human and/or colonial metabolism to phenolic metabolites, which may be further conjugated and demethylated. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to phenolic metabolite urine plasma purple potato extract anthocyanin, solanum tuberosum l., acylated anthocyanins, mass spectrometry, postprandial metabolites, purple-fleshed potatoes and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

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On April 30, 2013, Mange, Yatin J.; Isloor, Arun M.; Malladi, Shridhar; Isloor, Shrikrishna; Fun, Hoong-Kun published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis and antimicrobial activities of some novel 1,2,4-triazole derivatives. And the article contained the following:

In the present investigation, a series of new Schiff bases were synthesized by the condensation of N-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-4-H/Me-benzamides with various substituted aromatic aldehydes in ethanol-dioxane mixture using catalytic amount of sulfuric acid. The starting materials N-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-4-H/Me-benzamides were in turn synthesized by the fusion of (4-H/Me-benzoyl)-glycines with thiocarbohydrazide. Newly synthesized compounds were characterized by IR, NMR, mass spectra and elemental analyses. All the compounds were evaluated for their antibacterial and antifungal activity using the Min. Inhibition Concentration (MIC) method by serial dilution technique. Few of the compounds were found to be biol. active. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to thiocarbohydrazide aroylglycine cyclocondensation, aminomercaptotriazole arylamidomethyl preparation condensation aryl aldehyde, schiff base triazolethiol preparation antibacterial antifungal and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

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Boscari, Carolina Nasser; Mazzuia, Giovanna Rodrigues; Wisniewski, Celio; Borges, Keyller Bastos; Figueiredo, Eduardo Costa published an article in 2017, the title of the article was Molecularly imprinted probe for solid-phase extraction of hippuric and 4-methylhippuric acids directly from human urine samples followed by MEKC analysis.SDS of cas: 27115-50-0 And the article contains the following content:

Hippuric acid (HA) and 4-methylhippuric acid (4-MHA) are metabolites as well as biol. indicators for toluene and xylenes, resp., and their determination in urine samples is very important, in order to monitor the occupational exposition to these solvents, ensuring a safe working environment. Thus, this paper describes the synthesis and characterization of a probe impregnated with molecularly imprinted polymers (MIPs) for the solid-phase extraction of HA and 4-MHA directly from untreated urine samples followed by micellar electrokinetic chromatog. (MEKC) analyses. The MIP probe selectivity was compared to the non-imprinted polymer probe. The MEKC separations were carried out in 50 mmol/L sodium tetraborate pH 10.0/0.5 mmol/L cetyltrimethylammonium bromide aqueous solution, with a constant voltage of -15 kV. The system variables were optimized to provide ideal conditions for the extraction and desorption of the analytes, as well as for the MEKC analyses. The method was linear from 0.5 to 5.0 g/L for both analytes, with correlation coefficients > 0.994. Precisions and accuracies, expressed as relative standard deviation and relative error, were < 20.0 and within -15.4 to 16.6%, resp., in accordance with the United States Food and Drug Administration recommendation. The MIP probe has proven to be simple, cheap, resistant, and synthetically reproducible, being successfully used to analyze both HA and 4-MHA from real samples. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to hippurate methylhippurate molecularly imprinted polymer solid phase extraction mekc, capillary electrophoresis, hippuric acid, methylhippuric acid, molecularly imprinted polymer, urine and other aspects.SDS of cas: 27115-50-0

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Amide – an overview | ScienceDirect Topics

On January 7, 2015, Lill, Andreas P.; Roedl, Carmen B.; Steinhilber, Dieter; Stark, Holger; Hofmann, Bettina published an article.Computed Properties of 27115-50-0 The title of the article was Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy. And the article contained the following:

Different inflammatory diseases and allergic reactions are mediated by leukotrienes, which arise from the oxygenation of arachidonic acid catalyzed by 5-lipoxygenase (5-LO). One promising approach for an effective anti-leukotriene therapy (leukotriene antagonists) is the inhibition of this key enzyme. This study presents the synthesis and development of a potent and direct 5-LO inhibitor based on the well characterized 5-benzylidene-2-phenylthiazolone C06, whose further pharmacol. investigation was precluded due to its low solubility Through optimization of C06, evaluation of a structure-activity relationship including profound assessment of the thiazolone core and consideration of the solubility, the 5-benzyl-2-phenyl-4-hydroxythiazoles represented by ST-1829 [i.e., 5-(4-chlorobenzyl)-2-p-tolyl-4-thiazolol] were developed. ST-1829 showed an improved 5-LO inhibitory activity in cell-based (IC50 values 0.14 μM) and cell-free assays (IC50 values 0.03 μM) as well as a prominent enhanced solubility Furthermore, ST-1829 kept its promising inhibitory potency in the presence of blood serum, excluding excessive binding to serum proteins. These facts combined with the non-cytotoxic profile mark a major step towards an effective anti-inflammatory therapy. The synthesis of the target compounds was achieved using 2-thioxo-4-thiazolidinone, 4-methylbenzoic acid, aldehydes, nitriles as simple starting materials. The title compounds thus formed included 2-(4-chlorophenyl)-5-[(4-methoxyphenyl)methyl]-4-thiazolol, 5-[(4-methoxyphenyl)methylene]-2-(4-methylphenyl)-4-thiazolone and related substances. Analogs included (3E)-3-[(4-methoxyphenyl)methylene]-5-(4-methylphenyl)-2(3H)-furanone, (4Z)-4-[(4-methoxyphenyl)methylene]-2-(4-methylphenyl)-5(4H)-oxazolone. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Computed Properties of 27115-50-0

The Article related to thiazole thiazolone thiazolol preparation leukotriene antagonist, 5-lipoxygenase, anti-leukotriene therapy, hydroxythiazoles, inflammation, solubility, structure–activity relationship and other aspects.Computed Properties of 27115-50-0

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Konkle, Stacey L.; Zierold, Kristina M.; Taylor, Kira C.; Riggs, Daniel W.; Bhatnagar, Aruni published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. And the article contained the following:

Exposure to air pollution is a leading cause of global mortality. Volatile organic compounds (VOCs) are constituents of ambient air that could exert adverse health effects. To examine the relationship between VOC levels in ambient air and individual-level exposure to VOCs, as assessed by urinary VOC metabolites. Secular trends in 11 ambient air VOCs (2005-2013) and individual-level metabolites of 14 VOCs (2005-2014) were assessed using National Monitoring Programs (NMP) and National Health and Nutrition Examination Survey (NHANES) data, resp. To isolate environmental exposure, individuals reporting exposure to tobacco smoke were excluded. Quantile regression models were used to assess secular trends in VOC exposure, and survey-weighted regression models were built to identify factors associated with VOC exposure. All annual levels of ambient VOCs decreased from 2005 to 2013 (Range: 12.5%-77.2%). However, 11 of the corresponding VOC metabolites increased during the same time (Range: 0.3%-53.6%). There was a proportional change in patterns of VOC exposure across NHANES waves, with the middle quantiles of exposure showing the largest increase. VOC exposures were significantly associated with age, sex, race, education, and phys. inactivity, but not with secular VOC trends. In the United States, individual-level exposure to several VOCs increased between 2005 and 2014 despite a decline in ambient air VOC levels. This inverse relationship suggests that ambient VOCs are not the primary source of VOC exposure, therefore, decreasing ambient VOCs alone may not be sufficient to protect against the adverse health effects associated with VOC exposure. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to ambient air volatile organic compound biomarker united states, air pollution, biomarkers of exposure, environmental health, nhanes, secular trends, vocs, volatile organic compounds and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

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Amide – an overview | ScienceDirect Topics

Boyle, Elizabeth Barksdale; Viet, Susan M.; Wright, David J.; Merrill, Lori S.; Alwis, K. Udeni; Blount, Benjamin C.; Mortensen, Mary E.; Moye, John Jr.; Dellarco, Michael published an article in 2016, the title of the article was Assessment of exposure to VOCs among pregnant women in the National Children’s study.Computed Properties of 27115-50-0 And the article contains the following content:

Epidemiol. studies can measure exposure to volatile organic compounds (VOCs) using environmental samples, biomarkers, questionnaires, or observations. These different exposure assessment approaches each have advantages and disadvantages; thus, evaluating relationships is an important consideration. In the National Children’s Vanguard Study from 2009 to 2010, participants completed questionnaires and data collectors observed VOC exposure sources and collected urine samples from 488 third trimester pregnant women at in-person study visits. From urine, we simultaneously quantified 28 VOC metabolites of exposure to acrolein, acrylamide, acrylonitrile, benzene, 1-bromopropane, 1,3-butadiene, carbon disulfide, crotonaldehyde, cyanide, N,N-dimethylformamide, ethylbenzene, ethylene oxide, propylene oxide, styrene, tetrachloroethylene, toluene, trichloroethylene, vinyl chloride, and xylene exposures using ultra high performance liquid chromatog. coupled with an electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS) method. Urinary thiocyanate was measured using an ion chromatog. coupled with an electrospray ionization tandem mass spectrometry method (IC-ESI/MSMS). We modeled the relationship between urinary VOC metabolite concentrations and sources of VOC exposure. Sources of exposure were assessed by participant report via questionnaire (use of air fresheners, aerosols, paint or varnish, organic solvents, and passive/active smoking) and by observations by a trained data collector (presence of scented products in homes). We found several significant (p < 0.01) relationships between the urinary metabolites of VOCs and sources of VOC exposure. Smoking was pos. associated with metabolites of the tobacco constituents acrolein, acrylamide, acrylonitrile, 1,3-butadiene, crotonaldehyde, cyanide, ethylene oxide, N,N-dimethylformamide, propylene oxide, styrene, and xylene. Study location was neg. associated with the toluene metabolite N-acetyl-S-(benzyl)-L-cysteine (BMA), and paint use was pos. associated with the xylene metabolites 2-methylhippuric acid (2MHA) and 3-Methylhippuric acid & 4-methylhippuric acid (3MHA + 4MHA). A near-significant (p = 0.06) relationship was observed between acrylamide metabolites and observation of incense. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Computed Properties of 27115-50-0

The Article related to environmental exposure volatile organic compound pregnancy, national children’s study, birth cohort study, pregnant women, tobacco, urinary metabolites, volatile organic compounds and other aspects.Computed Properties of 27115-50-0

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Mut, Ludmila; Grobosch, Thomas; Binscheck-Domass, Torsten; Frenzel, Wolfgang published an article in 2016, the title of the article was Toxicological screening of human plasma by on-line SPE-HPLC-DAD: identification and quantification of acidic and neutral drugs.Category: amides-buliding-blocks And the article contains the following content:

A multi-analyte screening method for the quantification of 50 acidic/neutral drugs in human plasma based on online solid-phase extraction (SPE)-HPLC with photodiode array detection (DAD) was developed, validated and applied for clin. investigation. Acetone and methanol for protein precipitation, three different SPE materials (two electro-neutral, one strong anion-exchange, one weak cation-exchange) for online extraction, five HPLC-columns [one C18 (GeminiNX), two phenyl-hexyl (Gemini C6-Ph, Kinetex Phenyl-Hexyl) and two pentafluorophenyl (LunaPFP(2), KinetexPFP)] for anal. separation were tested. For sample pre-treatment, acetone in the ratio 1:2 (plasma:acetone) showed a better baseline and fewer matrix peaks in the chromatogram than methanol. Only the strong anion-exchanger SPE cartridge (StrataX-A, pH 6) allowed the extraction of salicylic acid. Anal. separation was carried out on a Gemini C6-Ph column (150 × 4.6 mm, 3 μm) using gradient elution with acetonitrile-water 90:10 (volume/volume) and phosphate buffer (pH 2.3). Linear calibration curves with correlation coefficients r ≥ 0.9950/0.9910 were obtained for 46/four analytes. Addnl., this method allows the quantification of 23 analytes for therapeutic drug monitoring. Limits of quantitation ranged from 0.1 (amobarbital) to 23 mg/L (salicylic acid). Inter-/intra-day precisions of quality control samples (low/high) were better than 13% and accuracy (bias) ranged from -14 to 10%. A computer-assisted database was created for automated detection of 223 analytes of toxicol. interests. Four cases of multi-drug intoxications are presented. Copyright © 2015 John Wiley & Sons, Ltd. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Category: amides-buliding-blocks

The Article related to drug toxicol screening human plasma spe hplc dad, acidic and neutral drugs, multi-analyte screening, on-line solid-phase extraction, plasma samples, systematic toxicological analysis, validation and other aspects.Category: amides-buliding-blocks

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On July 1, 2021, Chiu, Chun-Hui; Chen, Chi-Tsung; Cheng, Ming-Huei; Pao, Li-Heng; Wang, Chi; Wan, Gwo-Hwa published an article.Electric Literature of 27115-50-0 The title of the article was Use of urinary hippuric acid and o-/p-/m-methyl hippuric acid to evaluate surgical smoke exposure in operating room healthcare personnel. And the article contained the following:

Toluene and xylene are common components of surgical smoke, whereas hippuric acid (HA) and methylhippuric acid (MHA) are the products of toluene and xylene metabolism in humans, resp. HA and MHA can be used as indicators to evaluate the exposure hazards of toluene and xylene. In this study, we used liquid chromatog. tandem mass spectrometry (LC-MS/MS) to simultaneously analyze the HA, o-/m-/p-MHA, and creatinine contents in the urine of healthcare personnel. Concentrations of HA and o-/m-/p-MHAs were normalized to those of creatinine and used to analyze urine samples of 160 operating room (OR) healthcare personnel, including administrative staff, surgical nurses, nurse anesthetists, and surgeons. The results showed that the five analytes could be accurately separated and exhibited good linearity (r > 0.9992). The rate of recovery was between 86% and 106%, and the relative standard deviation was less than 5%. Urine from administrative staff presented the highest median concentration of hippuric acid (0.25 g/g creatinine); this was significantly higher than that found in the urine of surgeons (0.15 g/g). The concentrations of urinary o-/m-/p-MHAs in surgical nurses were higher than those in administrative staff, nurse anesthetists, and surgeons. Furthermore, the type, sex, and age of healthcare personnel were associated with changes in urine HA and o-/m-/p-MHA concentrations Healthcare personnel should be aware of the risk of exposure to surgical smoke. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to methyl hippuric acid surgical smoke occupational health hazard, high-performance liquid chromatography tandem mass spectrometry, hippuric acid, methylhippuric acid, operating room, surgical smoke and other aspects.Electric Literature of 27115-50-0

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De Jesus, Victor R.; Bhandari, Deepak; Zhang, Luyu; Reese, Christopher; Capella, Kimberly; Tevis, Denise; Zhu, Wanzhe; Del Valle-Pinero, Arseima Y.; Lagaud, Guy; Chang, Joanne T.; van Bemmel, Dana; Kimmel, Heather L.; Sharma, Eva; Goniewicz, Maciej L.; Hyland, Andrew; Blount, Benjamin C. published an article in 2020, the title of the article was Urinary biomarkers of exposure to volatile organic compounds from the population assessment of tobacco and health study wave 1 (2013-2014).Related Products of 27115-50-0 And the article contains the following content:

Volatile organic compounds (VOCs) are ubiquitous in the environment. In the United States (U.S.), tobacco smoke is the major non-occupational source of exposure to many harmful VOCs. Exposure to VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment of Tobacco and Health (PATH) Study is a U.S. national longitudinal study of tobacco use in the adult and youth civilian non-institutionalized population. We measured 20 VOCMs in urine specimens from a subsample of adults in Wave 1 (W1) (2013-2014) to characterize VOC exposures among tobacco product users and non-users. We calculated weighted geometric means (GMs) and percentiles of each VOCM for exclusive combustible product users (smokers), exclusive electronic cigarette (e-cigarette) users, exclusive smokeless product users, and tobacco product never users. We produced linear regression models for six VOCMs with sex, age, race, and tobacco user group as predictor variables. Creatinine-ratioed levels of VOCMs from exposure to acrolein, crotonaldehyde, isoprene, acrylonitrile, and 1,3-butadiene were significantly higher in smokers than in never users. Small differences of VOCM levels among exclusive e-cigarette users and smokeless users were observed when compared to never users. Smokers showed higher VOCM concentrations than e-cigarette, smokeless, and never users. Urinary VOC metabolites are useful biomarkers of exposure to harmful VOCs. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Related Products of 27115-50-0

The Article related to volatile oragnic compound metabolite biomarker tobacco smoke adult population, path study, e-cigarette users, smokeless tobacco users, tobacco smoke exposure, volatile organic compound metabolites and other aspects.Related Products of 27115-50-0

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Amide – an overview | ScienceDirect Topics