Category: 27115-50-0

Delgado, Gerzon E.; Guillen, Marilia; Ramirez, Jeans W.; Mora, Asiloe J.; Contreras, Jines E.; Chacon, Cecilia published an article in 2016, the title of the article was X-ray powder diffraction data for the N-acylamino acids: ortho, meta, and para-methyl hippuric acids.Recommanded Product: 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

N-acylamino acid isomers: ortho, meta, and para-methylhippuric acids, are specific xylene metabolites. Here, we report X-ray powder diffraction data, unit-cell parameters, and space groups for the three isomer (C10H11NO3), [ortho-methylhippuric acid 2 mHA, monoclinic P21/n cell, a = 8.522(1), b = 10.443(1), c = 10.734(1) Å, β = 92.43(1)°, V = 954.5(1) Å3; meta-methylhippuric acid 3 mHA, monoclinic C2/c cell a = 20.0951(2), b = 10.485(1), c = 10.074(2) Å, β = 119.08(1)°, V = 1933.9(1) Å3; para-methylhippuric acid 4 mHA, orthorhombic P212121 cell, a = 5.1794(7), b = 8.279(1), c = 22.276(2) Å, V = 955.2(2) Å3], space group. In each case, all measured diffraction peaks were indexed and are consistent with the corresponding space group. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 2-(4-Methylbenzamido)acetic acid

The Article related to xray powder diffraction methyl hippuric acylamino acid, Crystallography and Liquid Crystals: Polytypism, Polymorphism, Crystal Phase Transitions, Ordering, Amorphization and other aspects.Recommanded Product: 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 1, 2021, Gu, Xiaoke; Zhang, Yinpeng; Zou, Yueting; Li, Xin; Guan, Mingyu; Zhou, Qingqing; Qiu, Jingying published an article.Electric Literature of 27115-50-0 The title of the article was Synthesis and evaluation of new phenyl acrylamide derivatives as potent non-nucleoside anti-HBV agents. And the article contained the following:

As a continuation of our previous work, a series of new Ph acrylamide derivatives were designed and synthesized as non-nucleoside anti-HBV agents. Among them, compound I could potently inhibit HBV DNA replication in wild-type and lamivudine (3TC)/entecavir resistant HBV mutant strains with IC50 values of 0.19 and 0.18μM, resp. Notably, the selective index value of I was above 526, indicating the favorable safety profile. Interestingly, unlike nucleoside analog 3TC, I could significantly inhibit 3.5 kb pgRNA expression. Mol. docking study revealed that I could fit well into the dimer-dimer interface of HBV core protein by hydrophobic, π-π and H-bond interactions. Considering the potent anti-HBV activity, low toxicity and diverse anti-HBV mechanism from that of nucleoside anti-HBV agent 3TC, compound I might be a promising lead to develop novel non-nucleoside anti-HBV therapeutic agents, and warranted further investigation. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to ph acrylamide preparation potent non nucleoside antihbv agent safety, anti-hbv agents, non-nucleoside, phenyl acrylamide derivatives, synthesis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2022, Pinheiro, Danielle L. J.; Nielsen, Martin published an article.Safety of 2-(4-Methylbenzamido)acetic acid The title of the article was Chemoselective Transfer Hydrogenation of Enamides Using Ru Pincer Complexes for the Synthesis of α-Amino Acids. And the article contained the following:

The chemoselective reduction of enamides to α-amino acids with iPrOH and EtOH as H-donors and solvents catalyzed by Ru pincer complexes was demonstrated. A range of α-amino acids was synthesized in good to excellent yields. Applications, large scale and a one-pot experiment was also reported. Finally, deuterium-labeling experiments show high regioselectivity between the α- and β-positions of the alkene unit. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to aryl phenyl formamidopropenoate alkanol ruthenium catalyst chemoselective transfer hydrogenation, alkyl benzamido aryl propanoate preparation green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Peiyuan; Naduthambi, Devan; Mosley, Ralph T.; Niu, Congrong; Furman, Phillip A.; Otto, Michael J.; Sofia, Michael J. published an article in 2011, the title of the article was Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.Electric Literature of 27115-50-0 And the article contains the following content:

Phenylpropenamides have been reported to be a class of non-nucleoside inhibitors of the hepatitis B virus (HBV). This class of compounds was explored with the objective of developing potent anti-HBV agents, with a novel mechanism of action, that could be combined with nucleos(t)ide analogs currently used to treat HBV infection. To accomplish this objective a series of substituted arylpropenamides I (X = Br, Cl; R1 = Ph, 2-MeOC6H4, 1,3-dioxolan-4-yl, 2-FC6H4, 4-MeC6H4; R2 = Ph, 4-O2NC6H4, 4-MeO2SC6H4, etc.; R3R4N = 1-piperidinyl, 4-morpholinyl, 4-methyl-1-piperazinyl, etc.) was prepared and the E and Z geometrical isomers were separated The structural identity of each of the E and Z isomers of I (X = Cl; R1 = R2 = Ph; R3R4N = 1-piperidinyl) was determined by single crystal X-ray crystallog. Contrary to previous reports, the activity of this class of mols. resides in the Z isomer. Further structure-activity relationship studies around the active Z isomer identified compounds that displayed potent antiviral activity against HBV with EC90 value of approx. 0.5 μM in vitro. Attempts to develop ring constrained analogs did not lead to active HBV inhibitors. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to propenamide aryl aroylamino preparation antiviral hepatitis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Blanco-Lomas, Marina; Funes-Ardoiz, Ignacio; Campos, Pedro J.; Sampedro, Diego published an article in 2013, the title of the article was Oxazolone-Based Photoswitches: Synthesis and Properties.SDS of cas: 27115-50-0 And the article contains the following content:

The synthesis, photophysics and photochem. of a family of mol. switches inspired by the green fluorescent protein (GFP) chromophore is presented. These compounds can be synthesized in one step and good yields, their photophys. properties may be tuned by the substituents, solvent and wavelength of irradiation, and they show very efficient and fast photoisomerization. Furthermore, their high thermal stability and limited photodecomposition could allow these switches to be used in a range of applications. Finally, oxazolone photoswitches may be activated by the use of light and deactivated by either heat or light of a different wavelength. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to photophysics photochem oxazolone based photoswitch, mol switch oxazolone derivative photoisomerization, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ghafouri, Moloud; Moghadam, Majid; Mehrani, Kheirollah; Daneshvar, Anahita published an article in 2018, the title of the article was Supported ruthenium hydride catalysts for direct conversion of alcohols to carboxylic acids using styrene oxide as oxidant.Formula: C10H11NO3 And the article contains the following content:

In the present work, the ability of two ruthenium hydride catalysts supported on multiwall carbon nanotubes, [Ru-H@EDT-MWCNT], and gold nanoparticles cored triazine dendrimer, [Ru-H@AuNPs-TD], in the direct conversion of alcs. to carboxylic acids via transfer hydrogenation using styrene oxide as oxidant is reported. Different alcs. were successfully converted to their corresponding carboxylic acids. The results showed that these two heterogeneous catalysts are more efficient than the homogeneous counterpart. In addition, the catalysts were reused several times. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3

The Article related to ruthenium hydride catalyst supported alc styrene oxide, carboxylic acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 4, 2015, Zhou, Xiaomeng; Wang, Qing; Zhao, Weihua; Xu, Songsong; Zhang, Wei; Chen, Junmin published an article.Electric Literature of 27115-50-0 The title of the article was Palladium-catalyzed ortho-arylation of benzoic acid derivatives via C-H bond activation using an aminoacetic acid bidentate directing group. And the article contained the following:

A highly efficient protocol for the palladium-catalyzed ortho-arylation of benzoic acid derivatives by aryl iodides is described with an aminoacetic acid based N,O bidentate directing group. This protocol can be applied to various benzoyl aminoacetic acids and aryl iodides with both electron-donating and electron-withdrawing groups. Remarkably, the nature of a new directing group drives selective C-H bond activation to afford only monoarylation products in good to excellent yields. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to benzoyl aminoacetic acid aryl iodide ortho arylation palladium catalyst, arylbenzoic amide acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Leimbacher, Markus; Zhang, Yixin; Mannocci, Luca; Stravs, Michael; Geppert, Tim; Scheuermann, Joerg; Schneider, Gisbert; Neri, Dario published an article in 2012, the title of the article was Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library.Synthetic Route of 27115-50-0 And the article contains the following content:

Libraries of chem. compounds individually coupled to encoding DNA tags (DNA-encoded chem. libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNA-encoded chem. library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic anal. of selection strategies and statistically robust identification of binding mols. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by mol. docking. Our findings suggest that DNA-encoded chem. libraries allow the facile identification of drug-like ligands principally to any protein of choice, including mols. capable of disrupting high-affinity protein-protein interactions. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Synthetic Route of 27115-50-0

The Article related to dna encoded chem library drug discovery protein ligand, interleukin 2 inhibitor dna encoded chem library, tumor antigen carbonic anhydrase ix inhibitor dna encoded library and other aspects.Synthetic Route of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 12, 2019, Zamani, Parisa; Phipps, Joshua; Hu, Jiyun; Cheema, Faizan; Amiri Rudbari, Hadi; Bordbar, Abdol-Khalegh; Khosropour, Ahmad R.; Beyzavi, Hudson published an article.Safety of 2-(4-Methylbenzamido)acetic acid The title of the article was Multicomponent Synthesis of Diversified Chromeno[3,2-d]oxazoles. And the article contained the following:

A practical and efficient synthetic procedure to novel chromeno[3,2-d]oxazoles through a one-pot sequential multistep process is presented. This procedure proceeds efficiently in propylene carbonate (PC) as a green solvent and affords a wide range of the chromenooxazole scaffolds. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to chromeno oxazole diversity oriented synthesis multistep cyclization, chromenooxazoles, one-pot multicomponent reaction, propylene carbonate, sequential annulation reactions and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2020, Wang, Dong; Fu, Zhifei; Xing, Yanchao; Tan, Yao; Han, Lifeng; Yu, Haiyang; Wang, Tao published an article.Synthetic Route of 27115-50-0 The title of the article was Rapid identification of chemical composition and metabolites of Pingxiao Capsule in vivo using molecular networking and untargeted data-dependent tandem mass spectrometry. And the article contained the following:

Pingxiao capsule (PXC) is a herbal medicine used for adjuvant therapy in breast cancer. However, the constituents and absorbed components of the formula and their related metabolites have not been elucidated to date. PXC is a typical traditional Chinese medicine formula consisting of Strychnos nux-vomica L., Curcuma wenyujin Y. H., Agrimonia pilosa Ledeb., Toxicodendron vernicifluum, Trogopterus dung, alumen, potassium nitrate (saltpeter) and Citrus aurantium L. In this study, a ultra-high performance liquid chromatog. system equipped with high resolution Q-Orbitrap mass spectrometry (MS) and comparative Global Natural Product Social mol. networking together with the Compound Discoverer software were used to identify metabolites of PXC in vitro and in vivo. Based on untargeted data-dependent MS2 and data-mining techniques, 89 peaks of alkaloids, flavonoids, organic acid and phenolic compounds were identified in a PXC 70% methanol extract Furthermore, 15 absorbed prototype compounds and their metabolites were rapidly confirmed in rat blood. Glucuronidation, oxidation, methylation and hydroxylation were the main metabolic pathways. We fully clarified the chem. constituents of PXC and provided a scientific and efficient strategy for rapid discovery and identification of prototypes and their metabolites in rat plasma using high-resolution MS aided by Global Natural Product Social and Compound Discoverer software. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Synthetic Route of 27115-50-0

The Article related to pingxiao capsule chem composition metabolite mol networking mass spectrometry, pingxiao capsule, chemical constituents, mass spectrometry, metabolites, molecular networking and other aspects.Synthetic Route of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics