Category: 27115-50-0

On May 31, 2018, Urut, Gulsiye Ozturk; Aydin, Seher; Topkaya, Derya; Sahin, Elif; Alp, Serap published an article.COA of Formula: C10H11NO3 The title of the article was Synthesis, Spectroscopic Characterization and Polymerization Abilities of Blue and Green Light Emitting Oxazol-5-one Fluorophores. And the article contained the following:

New fluorescent thiophenyl group containing oxazol-5-one fluorophores of 3a (4-(3-thiophenylmethylene)-2-phenyloxazol-5-one), 3b (4-(3-thiophenylmethylene)-2-(4-tolyl)oxazol-5-one) and 3c (4-(3-thiophenylmethylene)-2-(4-nitrophenyl)oxazol-5-one) were synthesized and characterized. The newly synthesized oxazol-5-ones absorption and fluorescence characteristics were studied in some solvents of varying polarities. The heterocyclic chromophores were fluorescent, with two of them, 3a and 3b, emitting blue light, while the other one, 3c, emitting green light. The emission maxima of the derivatives varied between 415 and 572 nm according as the extent of conjugation and solvent polarity. As solvent polarity increased, 3c derivatives emission spectra displayed a large bathochromic shift, which revealed the considerable change of the dipole moment of the fluorescent structure because of an intramol. charge transfer interaction. Furthermore, oxazolones polymerization ability via the thiophenyl group linked to the oxazol-5-one heterocycle showed that copolymerization of 3a was achieved, but homopolymerization was not observed The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).COA of Formula: C10H11NO3

The Article related to fluorophore green light emitting polymerization ability oxazolone, copolymer, fluorescence, homopolymer, oxazol-5-one, thiophenes, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.COA of Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A. K., Ajeesh Kumar; Bodke, Yadav D.; Gowda, Ashwath N.; Sambasivam, Ganesh; Bhat, Kishore G. published an article in 2017, the title of the article was Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of Imidazolone Fused Pyrazolo[1,5-a]pyrimidine Derivatives.Name: 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

A novel series of imidazolone fused pyrazolo[1,5-a]pyrimidine derivatives has been designed and synthesized using a convergent approach, and the structures of these compounds were confirmed by 1H NMR, 13C NMR, ESI-MS, and IR analyses. These new compounds were tested for their in vitro antiproliferative activity using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Out of the 20 derivatives prepared in the current study, some compounds exhibited good anticancer activities tested against HeLa cells and HepG2 cells. However, the in vitro anticancer activity of compound I against HeLa, HepG2, and MCF-7 cell lines is superior to the marketed drugs Paclitaxel and SAHA. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Name: 2-(4-Methylbenzamido)acetic acid

The Article related to imidazolone fused pyrazolopyrimidine preparation anticancer activity, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chandraprakash, B.; Sarangapani, M. published an article in 2021, the title of the article was Synthesis, characterization, anticancer and antibacterial activity of 4-(benzylidene)-1-(pyrimidin-2-amino)-2-(p-tolyl)-1, 4-dihydro-4H-imidazol-5-one.Name: 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

In present study, conventional synthesis of 4-(benzylidene)-1-(pyrimidin-2-amino)-2-(p-tolyl)-1, 4-dihydro-4H-imidazol-5-ones I [R = H, Me, Cl, etc.; R1 = H, MeO, NO2] was performed. All the synthesized products I were purified through column chromatog. and structures of these compounds were characterized by IR, 1H NMR and mass spectral data. All the final compounds I were screened for their anticancer and antibacterial activity and their efficacy were matched with standard drugs. The synthesized compounds I [R = Me, NO2, MeO, Br; R1 = H, MeO] showed good anticancer activities whereas others exhibited significant activities. The compounds I [R = Cl, MeO, NO2; R1 = H, MeO] has showed maximum antibacterial activity compare with streptomycin as a standard drug. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Name: 2-(4-Methylbenzamido)acetic acid

The Article related to benzylidene pyrimidinyl amino tolyl dihydroimidazolone preparation antibacterial antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 1, 2012, Takahashi, Daisuke; Honda, Yutaka; Izawa, Kunisuke published an article.Product Details of 27115-50-0 The title of the article was Syntheses of 5-amino-2-phenyl-4(3H)-pyrimidinone derivatives starting with glycine. And the article contained the following:

N-Cbz-5-amino-2-phenyl-4(3H)-pyrimidinone was prepared from the Na salt of Me (hydroxymethylene)glycinate and benzamidine.HCl in good yield. However, the reaction with N-substituted benzamidine did not proceed to give the desired pyrimidinone. In contrast, the reaction of 4-ethoxymethylene-2-phenyl-5(4H)-oxazolone, readily prepared from hippuric acid and N-substituted benzamidine, proceeded nicely to give 5-(benzoylamino)-6-oxo-2-phenyl-1(6H)-pyrimidineacetate in high yield. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Product Details of 27115-50-0

The Article related to glycine benzamidine cyclocondensation, hippuric acid benzamidine cyclocondensation, aminopyrimidinone preparation, pyrimidinone amino preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 31, 2017, Ozturk Urut, Gulsiye; Alp, Serap; Topkaya, Derya published an article.Recommanded Product: 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis and characterization of new green and orange region emitting anthracene based oxazol-5-one dyes. And the article contained the following:

New anthracene oxazol-5-one dyes featuring an extended π-conjugated electron system have been successfully prepared by Erlenmeyer synthesis, structurally characterized and their spectroscopic properties were investigated by UV-vis absorption spectroscopy and fluorescence spectroscopy. The oxazol-5-ones were attached to the 9-position of the anthracene to obtain the desired structures. The dyes are having extended conjugation throughout their structure with oxazol-5-one ring as the chromophore. The spectral properties of the oxazol-5-one ring were monitored with respect to the substituents at the Ph ring. All of the dyes synthesized show good solubility in common organic solvents. Also in order to establish whether there was any solvent affects the absorption and emission spectra of the compounds were measured in the solvents of acetonitrile, THF and chloroform which have different polarity. Moreover, their absorption and emission properties were investigated in plasticized PVC film matrix. In comparison to the solution phase, the dyes displayed enhanced fluorescence emission quantum yield values when embedded in poly(vinyl chloride) polymer film. The anthracene based oxazol-5-ones were found to emit in the green portion of the spectrum for 2a and 2b, and in the orange portion of the spectrum for 2c. By attachment of nitro substituent at the para position of the Ph ring bound to oxazol-5-one core, the fluorescence maxima could be effectively modulated from the green region of the spectra to the orange region. 4-(9-anthralydene)-2-(4-nitrophenyl)oxazol-5-one (2c) exhibits large Stokes shift up to 146 nm presumably due to intramol. charge transfer. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 2-(4-Methylbenzamido)acetic acid

The Article related to anthracene based oxazolone dye solubility fluorescence, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Recommanded Product: 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2013, Barati, Behjat; Moghadam, Majid; Rahmati, Abbas; Tangestaninejad, Shahram; Mirkhani, Valiollah; Mohammadpoor-Baltork, Iraj published an article.Electric Literature of 27115-50-0 The title of the article was Ruthenium Hydride Catalyzed Direct Oxidation of Alcohols to Carboxylic Acids via Transfer Hydrogenation: Styrene Oxide as Oxygen Source. And the article contained the following:

Direct oxidation of alcs. to carboxylic acids using styrene epoxide as oxidant in the presence of [RuHCl(CO)(PPh3)3] complex as catalyst is reported. By this catalytic system, a variety of primary alcs. including substituted benzyl alcs. as well as linear ones were directly converted into carboxylic acids in good to excellent yields. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to ruthenium hydride direct oxidation alc carboxylic acid transfer hydrogenation, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zamani, Parisa; Khosropour, Ahmad R. published an article in 2016, the title of the article was A combination of natural deep eutectic solvents and microflow technology: a sustainable innovation for the tandem synthesis of 3-aminohexahydrocoumarins.Name: 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

We describe herein the first, straightforward, green, and metal-free tandem continuous flow pseudo-four component reaction to form 3-aminohexahydrocoumarins using choline chloride-urea as a natural deep eutectic solvent. This technol. exhibited superior yields relative to the batch reactions. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Name: 2-(4-Methylbenzamido)acetic acid

The Article related to eutectic microflow technol aminohexahydrocoumarin, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2011, Suzdalev, K. F.; Den’kina, S. V. published an article.Recommanded Product: 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis of 1-(oxiran-2-ylmethyl)-1H-indole-3-carbaldehyde and its reaction with active methylene compounds. And the article contained the following:

Treatment of indole-3-carbaldehyde with epichlorohydrin gave 1-(oxiran-2-ylmethyl)-1H-indole-3-carbaldehyde, reaction of which with 1,3-dimethylbarbituric acid or malononitrile gave crotonic condensation products with retention of the oxirane ring. The structure of the reaction products with aroylglycines depends on the conditions. In acetic anhydride a simultaneous formation of an oxazolone ring and bisacylation of the oxirane fragment occurs; the use of Et chloroformate in the presence of triethylamine resulted in only the heterocyclization process. When treated with the cyclic amines (N-methylpiperazine or morpholine), opening of the oxazolone ring in the products occurs with formation of the corresponding amides. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 2-(4-Methylbenzamido)acetic acid

The Article related to oxiranylmethylindolecarbaldehyde preparation reaction active methylene compound, indolecarbaldehyde oxiranylmethyl preparation reaction active methylene compound, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2014, Swapna, M.; Basha, N. Mahaboob; Padmaja, A.; Padmavathi, V. published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis of amino derivatives of 3-(4-phenyl-1,2,3-triazolyl)benzamine. And the article contained the following:

A new class of amino derivatives of 3-(4-phenyl-1,2,3-triazolyl)benzamine were prepared using different electrophilic reagents under ultrasonication and microwave methodologies. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to phenyltraizolyl benzeneamine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 13, 2022, Steadman, David; Atkinson, Benjamin N.; Zhao, Yuguang; Willis, Nicky J.; Frew, Sarah; Monaghan, Amy; Patel, Chandni; Armstrong, Emma; Costelloe, Kathryn; Magno, Lorenza; Bictash, Magda; Jones, E. Yvonne; Fish, Paul V.; Svensson, Fredrik published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. And the article contained the following:

Notum is a neg. regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Inhibitors of Notum could be of use in diseases where dysfunctional Notum activity is an underlying cause. A docking-based virtual screen (VS) of a large com. library was used to short-list 952 compounds for exptl. validation as inhibitors of Notum. The VS was successful with 31 compounds having an IC50 < 500 nM. A critical selection process was then applied with two clusters and two singletons selected for hit validation. Optimization of I guided by structural biol. identified potent inhibitors of Notum activity that restored Wnt/β-catenin signaling in cell-based models. The [1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one series represent a new chem. class of Notum inhibitors and the first to be discovered by a VS campaign. These results demonstrate the value of VS with well-designed docking models based on X-ray structures. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to triazolopyridazinone preparation carboxylesterase notum inhibitor screening, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three Or More Hetero Atoms and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics